Publications

Chang C, Zhao Q, Gonzalez JP, Kim JH, Alzahrani, Del Re DP and Fraidenraich D. Hematopoietic Id deletion triggers endomyocardial fibrotic and vascular defects in the adult heart. Sci. Rep. 2017; 7(1):3079.

Zhang Y and Del Re DP*. A growing role for the Hippo signaling pathway in the heart. J. Mol. Med. 2017; 95(5):465-472. *Corresponding author.

Matsuda T, Jeong JI, Ikeda S, Yamamoto T, Gao S, Babu GJ, Zhai P and Del Re DP*. H-Ras isoform mediates protection against pressure overload-induced cardiac dysfunction in part through activation of Akt. Circ. Heart Fail. 2017; 10(2):. *Corresponding author.

Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong JI, Ikeda S, Park JY, Hsu CP, Tian B, Pan D, Sadoshima J and Del Re DP*. NF2 activates Hippo signaling and promotes ischemia/reperfusion injury in the heart. Circ. Res. 2016; 119(5):596-606. *Corresponding author.

Nakamura M, Zhai P, Del Re DP, Maejima Y and Sadoshima J. Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury. JCI Insight; 1(5), 2016.

Del Re DP*. Hippo signaling in the heart: Non-canonical pathways impact growth, survival and function. Circ. J. 2016; 80(7):1504-10. *Corresponding author.

Yang Y*, Del Re DP*, Nakano N, Sciarretta S, Zhai P, Park JY, Sayed D, Matsushima S, Park Y, Tian B, Abdellatif M and Sadoshima J. miR-206 mediates YAP-induced cardiac hypertrophy and survival. Circ. Res. (In Press) *Equal contribution.

Sciarretta S, Zhai P, Maejima Y, Del Re DP, Nagarajan N, Yee D, Liu T, Magnuson MA, Volpe V, Frati G, Li H and Sadoshima J. mTORC2 regulates cardiac response to stress by inhibiting MST1. Cell Reports 2015; 11(1):125-36.

Del Re DP*. The Hippo signaling pathway: implications for heart regeneration and disease. Clin. Transl. Med. 2014; 3:27. *Corresponding author

Wackerhage H, Del Re DP, Judson RN, Sudol M and Sadoshima J. The Hippo signal transduction network in skeletal and cardiac muscle. Sci. Signal. 2014; 7(337).

Del Re DP and Sadoshima J. Elucidating ERK2 function in the heart. J. Mol. Cell. Cardiol. 2014; 72: 336-8.

Del Re DP, Matsuda T, Zhai P, Maejima Y, Jain MR, Liu T, Li H, Hsu CP, and Sadoshima J. Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL. Mol. Cell 2014; 54(4): 639-50.

Shao D, Zhai P, Del Re DP, Sciarretta S, Yabuta N, Nojima H, Lim DS, Pan D and Sadoshima J. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat. Commun. 2014; 5:3315.

Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S,Del Re DP, Zablocki DK, Hsu CP, Lim DS, Isobe M and Sadoshima J. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat. Med. 2013; 19(11):1478-88.

Del Re DP, Yang Y, Nakano N, Cho J, Zhai P, Yamamoto T, Zhang N, Yabuta N, Nojima H, Pan D and Sadoshima J. Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J. Biol. Chem.2013; 288(6):3977-88.

Del Re DP and Sadoshima J. Enhancing the potential of cardiac progenitor cells: pushing forward with Pim-1. Circ. Res. 2012; 110(9):1154-6.

Del Re DP and Sadoshima J. RASSF1A signaling in the heart: Novel functions beyond tumor suppression. Mol. Biol. Int. 2012; 2012:154283.

Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW and Brown JH. RhoA protects the mouse heart against ischemia/reperfusion injury. J. Clin. Invest. 2011; 121(8): 3269-76.

Del Re DP and Sadoshima J.  Is Raf1 a nexus for cardiac hypertrophic signaling in human disease?  J. Mol. Cell. Cardiol. 2011; 51(1):1-3.

Zhao Q, Beck AJ, Vitale JM, Schneider JS, Chang C, Gao S, Del Re DP, Bhaumik M, Yehia G, Sadoshima J, and Fraidenraich D. Injection of wild-type embryonic stem cells into Mst1 transgenic blastocysts prevents adult-onset cardiomyopathy.  Stem Cell Rev. 2011; 7(2):326-30.

Del Re DP, Matsuda T, Zhai P, Gao S, Clark GJ, Van Der Weyden L, and Sadoshima J. Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice.  J. Clin. Invest. 2010; 120(10): 3555-67.

Miyamoto S*, Del Re DP*, Xiang SY, Zhao X, Florholmen G, and Brown JH.  Revisited and Revised: Is RhoA always a villain in cardiac pathophysiology?  J. Cardiovasc. Transl. Res. 2010; 3(4): 330-43. *Equal contribution.

Del Re DP and Sadoshima J.  Optimizing cell-based therapy for cardiac regeneration.  Circulation 2009; 120(10):831-4.

Del Re DP, Miyamoto S, and Brown JH.  FAK as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection.  J. Biol. Chem. 2008; 283(51):35622-9.

Del Re DP, Miyamoto S, and Brown JH.  RhoA /Rho kinase upregulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis.  J. Biol. Chem. 2007; 282(11):8069-78.

Brown JH, Del Re DP and Sussman MA.  The Rac and Rho Hall of Fame: A Decade of Hypertrophic Signaling Hits.  Circ. Res. 2006; 98(6):730-42.