Publications

2023

  1. Zhang Y, Patel RP, Kim KH, Cho H, Jo JC, Jeong SH, Oh SY, Choi YS, Kim SH, Lee JH, Angelos M, Guruprasad P, Cohen I, Ugwuanyi O, Lee YG, Pajarillo R, Cho JH, Carturan A, Paruzzo L, Ghilardi G, Wang M, Kim S, Kim SM, Lee HJ, Park JH, Cui L, Lee TB, Hwang IS, Lee YH, Lee YJ, Porazzi P, Liu Dongfang, Lee Y, Kim JH, Lee JS, Yoon DH, Chung J, Ruella M. Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study. Mol Cancer. 2023 Dec 9;22(1):200. doi: 10.1186/s12943-023-01886-9.PMID: 38066564.
  2. Lubin JH, Markosian C, Balamurugan D, Ma MT, Chen CH, Liu Dongfang, Pasqualini R, Arap W, Burley SK, Khare SD. Modeling of ACE2 and antibodies bound to SARS-CoV-2 provides insights into infectivity and immune evasion. JCI Insight. 2023 Jul 10;8(13):e168296. doi: 10.1172/jci.insight.168296.PMID: 37261904.
  3. Gan J, Cho JH, Lee R, Naghizadeh A, Poon LY, Wang E, Hui Z, Liu Dongfang. Methods of Machine Learning-Based Chimeric Antigen Receptor Immunological Synapse Quality Quantification. Methods Mol Biol. 2023;2654:493-502. doi: 10.1007/978-1-0716-3135-5_32.PMID: 37106203.
  4. Cho JH, Tsao WC, Naghizadeh A, Liu Dongfang. Standardized protocol for the evaluation of chimeric antigen receptor (CAR)-modified cell immunological synapse quality using the glass-supported planar lipid bilayer. Methods Cell Biol. 2023;173:155-171. doi: 10.1016/bs.mcb.2022.07.009. Epub 2022 Sep 29.PMID: 36653082 

2022

  1. Badeti S, Jiang Q, Naghizadeh A, Tseng HC, Bushkin Y, Marras SAE, Nisa A, Tyagi S, Chen F, Romanienko P, Yehia G, Evans D, Lopez-Gonzalez M, Alland D, Russo R, Gause W, Shi L, Liu Dongfang. Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection. Cell Biosci. 2022 Jun 11;12(1):88. doi: 10.1186/s13578-022-00822-6.PMID: 35690792.
  2. Naghizadeh A, Tsao WC, Hyun Cho J, Xu H, Mohamed M, Li D, Xiong W, Metaxas D, Ramos CA, Liu Dongfang. In vitro machine learning-based CAR T immunological synapse quality measurements correlate with patient clinical outcomes. PLoS Comput Biol. 2022 Mar 18;18(3):e1009883. doi: 10.1371/journal.pcbi.1009883. eCollection 2022 Mar. PMID: 35303007.  
  3. Ma M, Badeti S, Kim JK, Liu Dongfang. Natural Killer (NK) and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line. J Vis Exp. 2022 Feb 8;(180):10.3791/62336. doi: 10.3791/62336.PMID: 35225261.  

2021

  1. Ma MT, Badeti S, Chen CH, Kim J, Choudhary A, Honnen B, Reichman C, Calianese D, Pinter A, Jiang Q, Shi L, Zhou R, Xu H, Li Q, Gause W, Liu Dongfang. CAR-NK Cells Effectively Target SARS-CoV-2-Spike-Expressing Cell Lines In Vitro. Front Immunol. 2021 Jul 23;12:652223. doi: 10.3389/fimmu.2021.652223. eCollection 2021.PMID: 34367128.
  2. Rajpoot S, Wary KK, Ibbott R, Liu Dongfang, Saqib U, Thurston TLM, Baig MS. TIRAP in the Mechanism of Inflammation. Front Immunol. 2021 Jul 8;12:697588. doi: 10.3389/fimmu.2021.697588. eCollection 2021.PMID: 34305934.
  3. Wang, X., Chen, C. H., Badeti, S., Cho, J. H., Naghizadeh, A., Wang, Z., & Liu, Dongfang. Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell-cell fusion. Cell Biosci. 2021 Jun 23;11(1):114. doi: 10.1186/s13578-021-00626-0.PMID: 34162440.
  4. Xu, C., Wang, A., Geng, K., Honnen, W., Wang, X., Bruiners, N., Singh, S., Ferrara, F., D'Angelo, S., Bradbury, A., Gennaro, M. L., Liu, Dongfang, Pinter, A., & Chang, T. L. Human Immunodeficiency Viruses Pseudotyped with SARS-CoV-2 Spike Proteins Infect a Broad Spectrum of Human Cell Lines through Multiple Entry Mechanisms. Viruses. 2021 May 21;13(6):953. doi: 10.3390/v13060953.PMID: 34064066.  
  5. Singh N, Frey NV, Engels B, Barrett DM, Shestova O, Ravikumar P, Cummins KD, Lee YG, Pajarillo R, Chun I, Shyu A, Highfill SL, Price A, Zhao L, Peng L, Granda B, Ramones M, Lu XM, Christian DA, Perazzelli J, Lacey SF, Roy NH, Burkhardt JK, Colomb F, Damra M, Abdel-Mohsen M, Liu T, Liu Dongfang, Standley DM, Young RM, Brogdon JL, Grupp SA, June CH, Maude SL, Gill S, Ruella M. Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells. Nat Med. 2021 May;27(5):842-850. doi: 10.1038/s41591-021-01326-5. Epub 2021 Apr 22. PMID: 33888899.
  6. Ziani W, Bauer A, Lu H, Wang X, Wu X, Bar KJ, Li H, Liu Dongfang, Shaw GM, Veazey RS, Xu H.  Immune Responses and Viral Persistence in Simian/Human Immunodeficiency Virus SHIV.C.CH848-Infected Rhesus Macaques. J Virol. 2021 Apr 12;95(9): e02198-20. doi: 10.1128/JVI.02198-20. Print 2021 Apr 12. PMID: 33568508.
  7. Wang S, Sun F, Huang H, Chen K, Li QJ, Zhang L, Wang E, Wang C, Zhang H, Yuan AQ, Chen B, Deng T, Liu Y, Sun J, Liu Dongfang, Yu Y, Fang Y, Jiang N, Wu D, Fang H, Bai Y, Xing S, Ni Y, Fan Q, Yu A, Sun C, Tang Y, Li N, Xu B, He J. The Landscape of Cell and Gene Therapies for Solid Tumors. Cancer Cell. 2021 Jan 11;39(1):7-8. doi: 10.1016/j.ccell.2020.12.005. PMID: 33434513.  
  8. Naghizadeh A, Metaxas DN, Liu Dongfang. Greedy auto-augmentation for n-shot learning using deep neural networks. Neural Netw. 2021 Mar;135:68-77. doi: 10.1016/j.neunet.2020.11.015. Epub 2020 Dec 13. PMID: 33360149.

2020

  1. Liu, D., Badeti, S., Dotti, G., Jiang, J. G., Wang, H., Dermody, J., Soteropoulos, P., Streck, D., Birge, R. B., & Liu, C. The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy. (2020) Cell communication and signaling: CCS18(1), 134. DOI: 10.1186/s12964-020-00617-7
  2. Tseng, H. C., Xiong, W., Badeti, S., Yang, Y., Ma, M., Liu, T., Ramos, C. A., Dotti, G., Fritzky, L., Jiang, J. G., Yi, Q., Guarrera, J., Zong, W. X., Liu, C., & Liu, D. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. (2020) Nature communications11(1), 4810. DOI: 10.1038/s41467-020-18444-2
  3. Yang, Y., Badeti, S., Tseng, H. C., Ma, M. T., Liu, T., Jiang, J. G., Liu, C., & Liu, D. Superior Expansion and Cytotoxicity of Human Primary NK and CAR-NK Cells from Various Sources via Enriched Metabolic Pathways. (2020) Molecular therapy. Methods & clinical development18, 428–445. DOI: 10.1016/j.omtm.2020.06.014
  4. Wang, X., Gupta, P., Jramne, Y., Danilenko, M., Liu, D., & Studzinski, G. P. Carnosic acid increases sorafenib-induced inhibition of ERK1/2 and STAT3 signaling which contributes to reduced cell proliferation and survival of hepatocellular carcinoma cells. (2020) Oncotarget11(33), 3129–3143. DOI: 10.18632/oncotarget.27687
  5. Baig, M. S., Roy, A., Rajpoot, S., Liu, D., Savai, R., Banerjee, S., Kawada, M., Faisal, S. M., Saluja, R., Saqib, U., Ohishi, T., & Wary, K. K. Tumor-derived exosomes in the regulation of macrophage polarization. (2020) Inflammation research: official journal of the European Histamine Research Society 69(5), 435–451. DOI: 10.1007/s00011-020-01318-0
  6. Pham, K., Huynh, D., Le, L., Delitto, D., Yang, L., Huang, J., Kang, Y., Steinberg, M. B., Li, J., Zhang, L., Liu, D., Tang, M. S., Liu, C., & Wang, H. E-cigarette promotes breast carcinoma progression and lung metastasis: Macrophage-tumor cells crosstalk and the role of CCL5 and VCAM-1. (2020) Cancer letters491, 132–145. DOI: 10.1016/j.canlet.2020.08.010
  7. Yan, H., Fernandez, M., Wang, J., Wu, S., Wang, R., Lou, Z., Moroney, J. B., Rivera, C. E., Taylor, J. R., Gan, H., Zan, H., Kolvaskyy, D., Liu, D., Casali, P., & Xu, Z. B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-κB Activation for Antibody Class-Switching. (2020) Journal of immunology204(5), 1146–1157. DOI: 10.4049/jimmunol.1901170
  8. Zheng, R., Yin, Z., Alhatem, A., Lyle, D., You, B., Jiang, A. S., Liu, D., Jobbagy, Z., Wang, Q., Aisner, S., & Jiang, J. G. Epidemiologic Features of NSCLC Gene Alterations in Hispanic Patients from Puerto Rico. (2020) Cancers12(12), 3492. DOI: 10.3390/cancers12123492
  9. Jiang, Z., Sun, X., Wu, Z., Alhatem, A., Zheng, R., Liu, D., Wang, Y., Kumar, D., Xia, C., You, B., Wang, H., Liu, C., & Jiang, J. G. Cytogenetic and molecular landscape and its potential clinical significance in Hispanic CMML patients from Puerto Rico. (2020) Oncotarget11(47), 4411–4420. DOI: 10.18632/oncotarget.27824

 

2019

  1. Wu, N., Sun, E., Liu, D., & Yu, D. Tissue-Specific Immunity in Homeostasis and Diseases. (2019) Journal of immunology research 7616509. DOI: 10.1155/2019/7616509
  2. Ni, H., Sun, X., Xu, Y., Lyle, D., Petersen, P., Zhao, X., Drum, H., You, B., Liu, D., Liu, C., & Jiang, J. G. Clinical implications of clonal chromosomal abnormalities in Philadelphia negative cells in CML patients after treated with tyrosine kinase inhibitors. (2019) Cancer genetics238, 44–49. https://doi.org/10.1016/j.cancergen.2019.07.008
  3. Alhatem, A., Badeti, S., Liu, C., Liu, D., Cai, D. Spontaneous Regression of Hepatic Diffuse Large B-cell Lymphoma in HIV and HCV Positive Patient: A Novel Case Study. (2019) Int J Cancer Clin Res 6:127. DOI: 10.23937/2378-3419/1410127

 

2018

  1. Xiong, W., Chen, Y., Kang, X., Chen, Z., Zheng, P., Hsu, Y. H., Jang, J. H., Qin, L., Liu, H., Dotti, G., & Liu, D. Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells. (2018) Molecular therapy: the journal of the American Society of Gene Therapy26(4), 963–975. DOI: 10.1016/j.ymthe.2018.01.020
  2. Nabekura, T., Chen, Z., Schroeder, C., Park, T., Vivier, E., Lanier, L. L., & Liu, D. Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection. (2018) Journal of immunology, 200(10), 3420–3428. DOI: 10.4049/jimmunol.1701639
  3. Huang, Y., Chen, Z., Jang, J. H., Baig, M. S., Bertolet, G., Schroeder, C., Huang, S., Hu, Q., Zhao, Y., Lewis, D. E., Qin, L., Zhu, M. X., & Liu, D. PD-1 blocks lytic granule polarization with concomitant impairment of integrin outside-in signaling in the natural killer cell immunological synapse. (2018) The Journal of allergy and clinical immunology142(4), 1311–1321.e8. DOI: 10.1016/j.jaci.2018.02.050
  4. Saqib, U., Kelley, T. T., Panguluri, S. K., Liu, D., Savai, R., Baig, M. S., & Schürer, S. C. Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets. (2018) Frontiers in pharmacology9, 1201. DOI: 10.3389/fphar.2018.01201
  5. Baig, M. S., Roy, A., Saqib, U., Rajpoot, S., Srivastava, M., Naim, A., Liu, D., Saluja, R., Faisal, S. M., Pan, Q., Turkowski, K., Darwhekar, G. N., & Savai, R. Repurposing Thioridazine (TDZ) as an anti-inflammatory agent. (2018) Scientific reports8(1), 12471. DOI: 10.1038/s41598-018-30763-5

 

2017

  1. Liu, D., Tian, S., Zhang, K., Xiong, W., Lubaki, N. M., Chen, Z., & Han, W. Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV. (2017) Protein & cell8(12), 861–877. DOI: 10.1007/s13238-017-0415-5
  2. Lee, Y. H., Martin-Orozco, N., Zheng, P., Li, J., Zhang, P., Tan, H., Park, H. J., Jeong, M., Chang, S. H., Kim, B. S., Xiong, W., Zang, W., Guo, L., Liu, Y., Dong, Z. J., Overwijk, W. W., Hwu, P., Yi, Q., Kwak, L., Yang, Z., … Liu, D. & Dong, C. Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function. (2017) Cell research27(8), 1034–1045. DOI: 10.1038/cr.2017.90
  3. Srivastava, M., Saqib, U., Naim, A., Roy, A., Liu, D., Bhatnagar, D., Ravinder, R., & Baig, M. S. The TLR4-NOS1-AP1 signaling axis regulates macrophage polarization. (2017) Inflammation research: official journal of the European Histamine Research Society 66(4), 323–334. DOI: 10.1007/s00011-016-1017-z
  4. Baig, M. S., Liu, D., Muthu, K., Roy, A., Saqib, U., Naim, A., Faisal, S. M., Srivastava, M., & Saluja, R. Heterotrimeric complex of p38 MAPK, PKCδ, and TIRAP is required for AP1 mediated inflammatory response. (2017) International immunopharmacology48, 211–218. DOI: 10.1016/j.intimp.2017.04.028

 

2016

  1. Roy, A., Srivastava, M., Saqib, U., Liu, D., Faisal, S. M., Sugathan, S., Bishnoi, S., & Baig, M. S. Potential therapeutic targets for inflammation in toll-like receptor 4 (TLR4)-mediated signaling pathways. (2016) International immunopharmacology40, 79–89. DOI: 10.1016/j.intimp.2016.08.026
  2. Bertolet, G., & Liu, D. The Planar Lipid Bilayer System Serves as a Reductionist Approach for Studying NK Cell Immunological Synapses and Their Functions. (2016) Methods in molecular biology1441, 151–165. DOI: 10.1007/978-1-4939-3684-7_13

 

2015

  1. Liu, D., & Chen, H. Structured illumination microscopy improves visualization of lytic granules in HIV-1 specific cytotoxic T-lymphocyte immunological synapses. (2015) AIDS research and human retroviruses31(9), 866–867. DOI: 10.1089/aid.2014.0363
  2. Zheng, P., Bertolet, G., Chen, Y., Huang, S., & Liu, D. Super-resolution imaging of the natural killer cell immunological synapse on a glass-supported planar lipid bilayer. (2015) Journal of visualized experiments: JoVE, (96), 52502. DOI: 10.3791/52502
  3. Zheng, P., Noroski, L. M., Hanson, I. C., Chen, Y., Lee, M. E., Huang, Y., Zhu, M. X., Banerjee, P. P., Makedonas, G., Orange, J. S., Shearer, W. T., & Liu, D. Molecular mechanisms of functional natural killer deficiency in patients with partial DiGeorge syndrome. (2015) The Journal of allergy and clinical immunology135(5), 1293–1302. DOI: 10.1016/j.jaci.2015.01.011
  4. Watkin, L. B., Jessen, B., Wiszniewski, W., Vece, T. J., Jan, M., Sha, Y., Thamsen, M., Santos-Cortez, R. L., Lee, K., Gambin, T., Forbes, L. R., Law, C. S., Stray-Pedersen, A., Cheng, M. H., Mace, E. M., Anderson, M. S., Liu, D., Tang, L. F., Nicholas, S. K., Nahmod, K., … Shum, A. K. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. (2015) Nature genetics47(6), 654–660. DOI: 10.1038/ng.3279
  5. Pone, E. J., Lam, T., Lou, Z., Wang, R., Chen, Y., Liu, D., Edinger, A. L., Xu, Z., & Casali, P. B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses. (2015) Journal of immunology, 194(7), 3065–3078. DOI: 10.4049/jimmunol.1401896
  6. Jang, J. H., Huang, Y., Zheng, P., Jo, M. C., Bertolet, G., Zhu, M. X., Qin, L., & Liu, D. Imaging of Cell-Cell Communication in a Vertical Orientation Reveals High-Resolution Structure of Immunological Synapse and Novel PD-1 Dynamics. (2015) Journal of immunology195(3), 1320–1330. DOI: 10.4049/jimmunol.1403143

 

2014

  1. Liu D. The adaptor protein Crk in immune response. (2014) Immunology and cell biology92(1), 80–89. DOI: /10.1038/icb.2013.64
  2. Gaiha, G. D., McKim, K. J., Woods, M., Pertel, T., Rohrbach, J., Barteneva, N., Chin, C. R., Liu, D., Soghoian, D. Z., Cesa, K., Wilton, S., Waring, M. T., Chicoine, A., Doering, T., Wherry, E. J., Kaufmann, D. E., Lichterfeld, M., Brass, A. L., & Walker, B. D. Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis. (2014) Immunity41(6), 1001–1012. DOI: 10.1016/j.immuni.2014.12.011

 

2013

  1. Long, E. O., Kim, H. S., Liu, D., Peterson, M. E., & Rajagopalan, S. Controlling natural killer cell responses: integration of signals for activation and inhibition. (2013) Annual review of immunology31, 227–258. DOI: 10.1146/annurev-immunol-020711-075005

 

2012

  1. Liu, D., Peterson, M. E., & Long, E. O. The adaptor protein Crk controls activation and inhibition of natural killer cells. (2012) Immunity36(4), 600–611. DOI: 10.1016/j.immuni.2012.03.007
  2. Chen, H., Ndhlovu, Z. M., Liu, D., Porter, L. C., Fang, J. W., Darko, S., Brockman, M. A., Miura, T., Brumme, Z. L., Schneidewind, A., Piechocka-Trocha, A., Cesa, K. T., Sela, J., Cung, T. D., Toth, I., Pereyra, F., Yu, X. G., Douek, D. C., Kaufmann, D. E., Allen, T. M., … Walker, B. D. TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. (2012) Nature immunology13(7), 691–700. DOI: 10.1038/ni.2342

 

Before 2012

  1. Liu, D., Martina, J. A., Wu, X. S., Hammer, J. A., 3rd, & Long, E. O. Two modes of lytic granule fusion during degranulation by natural killer cells. (2011) Immunology and cell biology89(6), 728–738. DOI: 10.1038/icb.2010.167
  2. Gross, C. C., Brzostowski, J. A., Liu, D., & Long, E. O. Tethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization. (2010) Journal of immunology, 185(5), 2918–2926. DOI: 10.4049/jimmunol.1000761
  3. Liu, D.*, Meckel, T.*, & Long, E. O. Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells. (2010) PloS one5(9), e12870. DOI: 10.1371/journal.pone.0012870 (* indicates co-first author)
  4. Liu, D., Bryceson, Y. T., Meckel, T., Vasiliver-Shamis, G., Dustin, M. L., & Long, E. O. Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses. (2009) Immunity31(1), 99–109. DOI: 10.1016/j.immuni.2009.05.009
  5. Ma, Y., Yang, H., Qi, J., Liu, D., Xiong, P., Xu, Y., Feng, W., Zheng, G., Li, P., Fang, M., Tan, Z., Zheng, F., & Gong, F. CD2AP is indispensable to multistep cytotoxic process by NK cells. (2010) Molecular immunology47(5), 1074–1082. DOI: 10.1016/j.molimm.2009.11.004
  6. Zhou, J.*, Liu, D.*, F., Liu, C., Kang, Z. M., Shen, X. H., Chen, Y. Z., Xu, T., & Jiang, C. L. Glucocorticoids inhibit degranulation of mast cells in allergic asthma via nongenomic mechanism. (2008) Allergy63(9), 1177–1185. DOI: 10.1111/j.1398-9995.2008.01725.x (* indicates co-first author)
  7. Liu, D.*, Xu, L.*, Yang, F., Li, D., Gong, F., & Xu, T. Rapid biogenesis and sensitization of secretory lysosomes in NK cells mediated by target-cell recognition. (2005) Proceedings of the National Academy of Sciences of the United States of America102(1), 123–127. DOI: 10.1073/pnas.0405737102 (* indicates co-first author)
  8. Liu, D., Zhang, J., Wu, J., Zhang, C., Xu, T. Altered calcium-induced exocytosis in neutrophils from allergic patients. (2004) Int Arch Allergy Immunol Aug;134(4):281-7. DOI: 10.1159/000079165. Epub 2004 Jun 17. PMID: 15205559.