3/22 - While our thoughts are with everyone battling COVID-19 on many fronts, we want to be grateful for our new publication in Cell Chemical Biology on recent advances in our KasA program. Daigo and Divya led the way to a preclinical drug candidate JSF-3285!
3/19/20 – Amidst the sobering news of the COVID-19 pandemic, we respectfully take the time to announce new funding from the NIH to further our collaborative studies of tuberculosis diagnostics with the Jain laboratory at Johns Hopkins. We are grateful for this support.
11/7/19 – Congratulations to Xin and Daigo who led the research published in Cell Chemical Biology. JSF-2019, discovered by our TB Bayesian model and published in 2013 in Chemistry & Biology, was explored as to its compound optimization and mechanism of action. IBDM and spontaneous 2019-resistant mutants led us to a proposed mechanism for JSF-2019 involving NO• release and InhA inhibition which distinguishes this nitrofuran triazine from other nitroheterocycles such as delamanid and pretomanid.
11/5/19 – Congratulations to Xin and Alex who led the research published in ACS Infectious Diseases. Utilizing a combination of our intrabacterial drug metabolism (IBDM) and computational (TB Bayesian model + high-throughput docking) platforms, they discovered a novel, whole-cell active InhA inhibitor whose mechanism is obscured by biotransformation/s within M. tuberculosis.
9/18/19 – Congratulations to the lab on new funding from the NIH in collaboration with Shumin Tan’s lab at Tufts.
7/25/19 – Congratulations to the lab on the acceptance of its paper with the Jain lab at Hopkins on the synthesis of 76Br-bedaquiline and its use in PET imaging with a mouse model of M. tuberculosis infection.
5/4 - Congratulations to Xin on receiving a best poster award at the NCI Frontiers in Chemical Biology meeting!
5/1 – The lab is grateful to the NIH for the award of a new CETR grant!
4/1 – Congratulations to the lab on new funding from the NIH in collaboration with Sanjay Jain’s lab at Johns Hopkins.
4/3 – Congratulations to Dr. Jimmy Patel on successfully defending his thesis. We wish him the best of luck returning for Y3 of medical school and encourage everyone to look for him to re-enter the research world in 2021!
4/15 – Congratulations to the lab on a new Ebola virus paper just accepted in Pharmaceutical Research.
9/20 - Congratulations to the lab on new funding from the DOD!
8/20 – Joel gave a talk today at the Boston ACS Meeting on recent advances within our Bayesian modeling program.
8/14 - Welcome to Janaina Cruz Pereira as a new post-doc in the group!
8/13 - Congratulations to the lab on an accepted paper in Tuberculosis on the antitubercular activity and mechanism of action of pyronaridine.
6/14/18 – Congratulations to Alex on his keynote review article "The A-Z of Zika drug discovery," which was just accepted for publication in Drug Discovery Today!
6/05/18 – Congratulations to Alex and Jimmy on their manuscript "Naive Bayesian models for Vero cell cytotoxicity," which was just accepted for publication in Pharmaceutical Research!
4/20/18 – Congratulations to Alex on our accepted paper in Molecular Pharmaceutics entitled "Comparing and validating machine learning models for Mycobacterium tuberculosis drug discovery."
3/06/18 – We are happy to announce a recently funded NIH STTR grant to further our antitubercular drug discovery studies. It was highlighted by the press and by an Inside NJMS article.
3/05/18 – Congratulations to Jimmy Patel!! Jimmy passed his qualifying exam with flying colors. Consequently, Jimmy is now officially an M.D. / Ph.D. Candidate.
1/24/18 – Congratulations to Alex for his contributions to a book chapter on Bayesian models in the recently published Computational Toxicology: Risk Assessment for Chemicals.
1/08/18 – Congratulations to Daigo, Alex, and former group members on their paper published at AAC! The manuscript is entitled "Novel pyrimidines as antitubercular agents."
9/14/17 – Congratulations to Tom, Alex, Shao-Gang, and Jimmy on their manuscript in ACS Medicinal Chemistry Letters entitled “Addressing the Metabolic Stability of Antituberculars through Machine Learning.”
9/6/17 – Congratulations to Jimmy on his fellowship award through the T32 training program in Infection, Immunity, and Inflammation!
9/1/17 – We are very excited to welcome master’s student Tenesha Body and Rutgers undergraduates Matthew Sherwood and Ethan Morrison to the group!
8/28/17 – Congratulations to Daigo, Ricardo, and Mark on their joint paper with the Brady lab in ACS Infectious Diseases, entitled “Human microbiome inspired antibiotics with improved β-lactam synergy againstMDR Staphylococcus aureus."
8/28/2017 – Congratulations to Dr. Nisha Mittal on her new Senior Scientist position in the Analytical department at Kashiv Pharma.
8/14/2017 – Congratulations to Jimmy for having his bio. featured on the Rutgers Department of Chemistry and Chemical Biology website, in the section with information for prospective students.
7/21/2017 – Congratulations to Shao-Gang on the acceptance of our manuscript in Antimicrobial Agents and Chemotherapy, entitled "Mycobacterium tuberculosis L,D-transpeptidases are susceptible to inactivation by carbapenems and cephalosporins but not penicillins."
7/01/2017 – Congratulations to Joel (and to the lab, of course!) on the award of tenure!! The trip to Puerto Rico will have to wait, though; many more papers are yet to be written....
6/26/2017 – Congratulations to Ashley on starting a neurology residency at Tufts!!
6/16/2017 – Congratulations to Xin on his poster at the Boston Bacterial Meeting on our new results studying the intramycobacterial metabolism of antitubercular agents.
6/15/2017 – Congratulations to Jimmy on his talk at the Boston Bacterial Meeting on our recent efforts with methicillin-resistant S.aureus (MRSA).
6/09/2017 – Congratulations to Sam on his acceptance to the Rutgers-New Jersey Medical School. We know he will be an amazing M.D. in just a few years!
6/02/2017 – Congratulations to Divya on her new position as a Scientist at the Infectious Disease Research Institute (IDRI). We wish her the best of luck!
5/17/2017 – Congratulations to Divya on the acceptance of her paper in Trends in Microbiology, which outlines our thoughts on the intrabacterial metabolism of small molecule antituberculars.