SELECTED PUBLICATIONS

 

ARTICLES | EDITORIALS | REVIEWS | BOOK CHAPTERS | BOOKS EDITED

 

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ARTICLES

  • Corcoran KE, Patel N, Rameshwar P. (2007) Stromal Derived Growth Factor-1a: Another mediator in neural-emerging immune system through Tac1 expression in bone marrow stromal cells. J Immunol 178:2075-82.
  • Ramkissoon SH, Patel PS, Taborga M, Rameshwar P. (2007) NFκB is central to the expression of truncated neurokinin-1 receptor in breast cancer: Implication for breast cancer cell quiescence within bone marrow stroma. Cancer Res67:1653-59.
  • Corcoran KE, Rameshwar P. (2007) NFκB and not receptor desensitization accounts for the repressor effects of high SDF-1a levels on Tac1 expression in non-tumorigenic breast cells. Mol Cancer Res 5:373-81.
  • Greco SJ, Zhou C, Ye J-H, Rameshwar P. (2007) An interdisciplinary approach and characterization of neuronal cells transdifferentiated from human mesenchymal stem cells. Stem Cells and Dev 16:811-826.
  • Greco SJ, Rameshwar P. (2007) Enhancing effect of IL-1a on neurogenesis from adult human mesenchymal stem cells: Implication for inflammatory mediators in regenerative medicine. J Immunol 179:3342-50.
  • Trzaska KA, Kuzhikandathil EV, Rameshwar P. (2007) Specification of a dopaminergic phenotype from adult human mesenchymal stem cells. Stem Cells 25:2797-808.
  • Greco SJ, Rameshwar P. (2007) miRNAs regulate synthesis of the neurotransmitter substance P in human mesenchymal stem cell-derived neuronal cells. Proc Natl Acad Sci USA (Track II)104:15484-9.
  • Greco SJ, Smirnov SV, Murthy RG, Rameshwar P. (2007) Synergy between RE-1 silencer of transcription and NFκB in the repression of the neurotransmitter gene Tac1 in human mesenchymal stem cells. J Biol Chem 282:282:30039-50.
  • Greco SJ, Liu K, Rameshwar P. (2007) Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells. Stem Cells 25:3143-54.
  • Metz R, Patel PS, Hameed M, Bryan M, Rameshwar P. (2007) Molecular analyses on the metastatic role of human HGFIN/nmb in breast cancer. Breast Cancer Res 9:R58. 
  • Patel N, Castillo M, Rameshwar P. (2007) An in vitro method to study the effects of hematopoietic regulators during immune and blood cell development. Biol Procedures Online 9:56-64.
  • Murthy RG, Greco SJ, Taborga M, Patel N, Rameshwar P. (2008) Tac1 regulation by RNA-binding protein and miRNA in bone marrow stroma: Implication for hematopoietic activity. Brain Behav Immunity 22:442-50.
  • Tang KC, Trzaska KA, Smirnov SV, Kotenko SV, Schwander SK, Ellner JJ, Rameshwar P. (2008) Down regulation of MHC-II in mesenchymal stem cells at high IFNγ can be partly explained by cytoplasmic retention of CIITA. J Immunol 180:1826-33.
  • Rameshwar P. (2008) Is substance P central to the biology of acute lymphoblastic leukemia? Leuk Res 32:3-4.
  • Corcoran KE, Malhotra A, Molina CA, Rameshwar P. (2008) SDF-1a induces a non-canonical pathway to activate the endocrine-linked Tac1 gene in non-tumorigenic breast cells. J Mol Endocrinol 40:113-123.
  • Castillo MD, Trzaska KA, Greco SJ, Ponzio NM, Rameshwar P. (2008) Immunostimulatory effects of mesenchymal stem cell-derived neurons: Implications for stem cell therapy in allogeneic transplantations. Clin Translational Sci 1:27-34.
  • Corcoran KE, Trzaska KA, Fernandes H, Bryan M, Taborga M, Srinivas V, Packman K, Patel PS, Rameshwar P. (2008) Mesenchymal stem cells in early entry of breast cancer into bone marrow. Plos ONE 3:e2563
  • Trzaska KA, Reddy BY, Munoz JL, Li K-Y, Ye J-H, Rameshwar P. (2008) Loss of RE-1 Silencing Factor in mesenchymal stem cell-derived dopamine progenitors induces functional maturity. Mol Cellular Neurosci 39:285-290.
  • Ricardo M, Trzaska KA, Rameshwar P. (2008) Neurokinin-A inhibits cell cycle activators in K562 cells and activates Smad 4 through a non-canonical pathway: A novel method in Neural-Hematopoietic Axis. J Neuroimmunol 204:85-91.
  • Greco S, Rameshwar P. (2008) A method to generate human mesenchymal stem cell-derived neurons which express and are excited by multiple neurotransmitters. Biol Procedure 10:90-101.
  • Liu K, Wong EW, Schutzer SE, Connell ND, Upadhyay A, Bryan M, Rameshwar P. (2009) Non-canonical effects of anthrax toxins on hematopoiesis: implications for vaccine development. J Cellular Mol Med 13:1907-1919.
  • Reddy BY, Greco SJ, Patel PS, Trzaska KA, Rameshwar P. (2009) RE-1 silencing transcription factor shows tumor suppressor functions and negatively regulates the oncogenic TAC1 in breast cancer cells. Proc Natl Acad Sci USA (Track II) 106:4408-13.
  • Trzaska KA, King CC, Le K-Y, Kuzhikandathil EV, Nowycky MC, Ye J-H, Rameshwar P. (2009) Brain derived neurotrophic factor facilitates maturation of mesenchymal stem cell-derived dopamine progenitors to functional neurons. J Neurochem 110:1058-1069.
  • Rameshwar P. (2010) Breast cancer cell dormancy in bone marrow: Potential therapeutic targets within the marrow microenvironment. Expert Rev Anti Cancer Therapy10:129-132.
  • Patel SA, Meyer J, Greco SJ, Corcoran KE, Bryan M, Rameshwar P. (2010) Mesenchymal stem cells protect breast cancer cells through regulatory T cells: Role of mesenchymal stem cell-derived TGF-β. J Immunol184:5885 -5894.
  • Lim PK, Bliss SA, Patel SA, Taborga M, Dave MA, Gregory LA, Greco SJ, Bryan M, Patel PS, Rameshwar P. Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells. Cancer Res (In press)

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EDITORIALS

  • Rameshwar P. (2008) IFNγ and B7-H1 in the immunology of mesenchymal stem cells. Cell Res 18:805-806.

  • Rameshwar  P. (2009) Casting doubt on the safety of `off-the-shelf' mesenchymal stem cells for cell therapy. Mol Therapy 7:216-218.

  • Rameshwar P. (2009) Microenvironment at tissue injury, a key focus for efficient stem cell therapy: A discussion of Mesenchymal Stem Cells. World J Stem Cells 1:3-7.

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REVIEWS

  • Taborga M, Corcoran KE, Fernandes N, Ramkissoon SH, Rameshwar P. (2007) G-coupled Protein Receptors and Breast Cancer Progression: Potential Drug Targets. Mini Rev in Med Chem 7:245-51.

  • Rameshwar P. (2007) Implication of possible therapies targeted for tachykinergic system with the biology of neurokinin receptors and emerging related proteins. Recent Patents on CNS Drug Discovery 2:79-84.

  • Trzaska KA, Rameshwar P. (2007) Current advances in the treatment of Parkinson’s Disease with stem cells. Curr Neurovascular Res 4:99-109.

  • Castillo M, Liu K, Bonilla L, Rameshwar P. (2007) The immune properties of Mesenchymal Stem Cells. Intl J Biomed Sci 3:100-104.

  • Murthy RG, Reddy BY, Ruggiero JE, Rameshwar P. (2007) Tachykinins and hematopoietic stem cell functions: implications in clinical disorders and tissue regeneration. Front Biosci 12:4779-87.

  • Liu K, Castillo DM, Murthy RG, Patel N, Rameshwar P. (2007) Tachykinins and Hematopoiesis. Clinica Chimica Acta 385:28-34.

  • Reddy BY, Trzaska KA, Murthy RG, Navarro P, Rameshwar P. (2008) Neurokinin receptors as potential targets in breast cancer treatment. Curr Drug Discov Technol 5:15-19.

  • Patel SA, Sherman L, Munoz J, Rameshwar P. (2008) Immunological Properties of Mesenchymal stem cells and clinical implications. Archivum Immunologiae et Therapiae Experimentalis 56:1-8.

  • Trzaska KA, Castillo MD, Rameshwar P. (2008) Adult mesenchymal stem cells in neural regeneration and repair: current advances and future prospects. Mol Med Reports 1:307-316.

  • Greco SJ, Rameshwar P. (2008) Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies. Biologics 2:699-705.

  • Patel S, Heinrich A, Reddy B, Srinivas B, Heidaran N, Rameshwar P. (2008) The Multifaceted Roles of Stem cells in breast cancer biology. J Oncol 2008: 425895.

  • Heinrich AC, Patel SA, Reddy BY, Milton R, Rameshwar P. (2009) Multi- and Inter-disciplinary science in personalized delivery of stem cells for tissue repair. Current Stem Cell Res Ther 4:16-22.

  • Patel SA, Heinrich AC, Reddy BY, Rameshwar P. (2009) Inflammatory mediators: Parallels between cancer biology and stem cell therapy. J Inflammation 2:13-19.

  • Rameshwar P. (2009) Potential novel targets in breast cancer. Curr Pharmaceutical Biotechnol 10:148-53.

  • Greco SJ, Rameshwar P. (2010) Recent Advances and Novel Approaches in Deriving Neurons from Stem Cells. Molecular BioSystems 6:324-328.

  • Rameshwar P, Qiu H, Vatner SF. (2010) Stem cells in cardiac repair in an inflammatory microenvironment. Minerva Cardioangiologica 58:127-146.

  • Patel SA, Ndabahaliye A, Lim PK, Milton R, Rameshwar P. (2010) Challenges in the development of future treatments for breast cancer stem cells. Breast Cancer 2:1-11.

  • Patel SA, King CC, Lim PK, Habiba U, Dave M, Porecha R, Rameshwar P. (2010) Personalizing Stem Cell Research and Therapy: The Arduous Road Ahead or Missed Opportunity? Curr Pharmacogenomics and Personalized Medicine 8:25-36.

  • Gregory LA, Ricart RA, Patel SA, Lim PK, Rameshwar P. (2010) microRNAs, Gap Junctional Intercellular Communication and Mesenchymal Stem Cells in Breast Cancer Metastasis. Current Cancer Therapy Review 6:...

  • Klassert TE, Patel SA, Rameshwar P. (2010) Tachykinins and neurokinin receptors in bone marrow functions: neural-hematopoietic link. J Receptor, Ligand and Channel Res 3:51-61.

  • Lim PK, Patel SA, Gregory LA, Rameshwar P. (2010) Neurogenesis: Role for microRNAs and Mesenchymal Stem Cells in Pathological States. Curr Med Chem 17:2159-67.

  • Helmy KY, Patel SA, Silverio K, Pliner L, Rameshwar P. (2010) Stem cells and regenerative medicine: accomplishments to date and future promise. Therapeutic Delivery 1:693-705.

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BOOK CHAPTERS

 

  • Rameshwar P. (2007) Mesenchymal Stem Cells as bone marrow `gate-keepers': Implications for hematological disorder. In Stem Cell Research Advances; Ed. Lydia P. Davenport; Nova Publishers, Hauppauge, NY, pp.137-147.

  • Trzaska KA, Greco SJ, Moore L, Rameshwar P. (2008) Mesenchymal Stem Cells and Transdifferentiated Neurons in Crosstalk with the Tissue Microenvironment: Implications for Translational Science. In Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging, Oxford Univ Press (Ed, Maiese K), p.215-230.

  • Rameshwar P, Bardeguez A. Molecular Basis of Cytokine Function. (2008) InThe Neuroimmunological Basis of Behavior and Mental Disorders, Springer-Verlag  (Eds, Siegel A & Zalcman S), p.59-70.

  • Navarrow P, Castillo M, Rameshwar P. Immune threat to neurogenesis from human adult mesenchymal stem cells. In Stem Cell Applications in Diseases; Ed. Burnsides WB & Ellsley RH; Nova Publishers, Hauppauge, NY, (In press).

  • King C, Patel S, Arinzeh-Livingston T, Rameshwar P. (2009) Dual roles of mesenchymal stem cells in spinal cord injury: Cell replacement therapy and as a model system to understand axonal repair. In Perspectives in Stem Cells: From tools for studying mechanisms of neuronal differentiation to towards therapy. Springer Dordrecht Heidelberg London New York (Ed, Hennig U), p.271-284.

  • Lim P, Patel SA, Rameshwar P. (2010) Effective tissue repair and immunomodulation by mesenchymal stem cells within a milieu of cytokines. In Stem Cell-Based Tissue Repair. Royal Society of Chemistry Publishing, Cambridge, UK (Eds, Gorodetsky R & Schäfer R), p.338-357.

  • Patel SA, Rameshwar P. (2010) Co-existence of hematopoietic stem cells and cancer cells during cancer quiescence. In Stem Cells: Organogenesis and Cancer. Transworld Res Network, Kerala, India (Eds. Singh SR, Mishra PK, Hou SX), p.139-151.

  • Trzaska KA, Ramkissoon S, Harrison JS, Rameshwar P. (2010) The Biology of Metastatic Neuroblastoma. In Cancer Metastasis. (Ed, P. Rameshwar), Transworld Res Network, Kerala, India. p.39-52.

  • Murthy RG, Fernandez J, Rameshwar P. (2010) Molecular and Cellular Events Preceding Bone Metastasis of Breast Cancer. In Cancer Metastasis. (Ed, P. Rameshwar), Transworld Res Network, Kerala, India. p.29-37.

  • Metz RL, Rameshwar P. (2010) HGFIN/Osteoactivin: A developing link in breast cancer biology. In Cancer Metastasis. (Ed, P. Rameshwar), Transworld Res Network, Kerala, India. p.53-62.

  • Homsi E, Grumm K, Rameshwar P. (2010) Predictive development of cancer as stem cell therapy approaches the bedside. In Cancer Metastasis. (Ed, P. Rameshwar), Transworld Res Network, Kerala, India. p.116-125.

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BOOKS EDITED

  • Cancer Metastasis (2010)