Harumi Jyonouchi, MD
Dr. Harumi Jyonouchi received her medical training at the Yokohama City University School of Medicine, Yokohama, Japan and then completed training in Pediatrics at Fujigaoka Hospital, Showa University, Japan. She then served as a research fellow at Sloan-Kettering Institute for Cancer Research in New York and then as a Senior Research Scientist at the Oklahoma Medical Research Foundation. She completed a fellowship in Pediatric Immunology at Oklahoma Children's Memorial Hospital, and did additional training in Allergy/Immunology at All Children's Hospital, St. Petersburg, Florida, where she joined the faculty as an Assistant Professor of Pediatrics and the Assistant Director of the Immunoparameter Laboratory. She went on to become an Associate Professor of Medicine at the University of Minnesota and served as the co-director for the Allergy/Immunology fellowship. She has been in the Department of Pediatrics at NJMS since 2002. She is the recipient of a number of honors and awards, and has served on NIH grant review committees and Editorial Boards. She is currently the Chief Editor of the Pediatrics Section of eMedicine. She has had continuous grant support since 1989 and is the author of over 100 published peer-reviewed articles and chapters. Her research interests include: neuro-immune interactions and epigenetic regulation in children with autism spectrum disorders, innate immune abnormalities in patients with mucosal inflammation of the airway (asthma) and the GI tract, and non-IgE mediated food allergy
1. Jyonouchi H and Yamaguchi M: A case of neonatal hyperbilirubinemia secondary due to Rh incompatibility. (in Japanese) J Pediatr Practice 40:2008-2011, 1977.
25. Jyonouchi H, Voss RM, and Good RA: IL-1 like activities present in murine amniotic fluid. A significantly larger amount of IL-1 like activity is present in the amniotic fluid of autoimmune NZB mice. J Immunol 138:3300-3307, 1987.
60. Jyonouchi H. Airway Epithelium and apoptosis. Apoptosis 4:407-417, 1999.
61. Jyonouchi H, Sun S, Iijima K, and Gross MD: Anti-tumor activity of astaxanthin and its mode of action. Nutr. Cancer 36: 59-65, 2000.
62. Jyonouchi H, Sun S, and Rimell FL: Cytokine production by sinus lavage, bronchial lavage, and blood mononuclear cells in chronic sinusitis with or without atopy. Archives of Otolaryngology-Head and Neck Surgery 126: 522-528, 2000
63. Jyonouchi H, Sun S, Kennedy CA, and Rimell FL: Interferon- levels in the sinus, ear, and airway in a rabbit sinusitis model induced by Bacteroides inoculation. Archives of Otolaryngology-Head and Neck Surgery 126: 529-532, 2000
64. Jyonouchi H, Sun S, Abiru T, Whinship, T, and Kuchan, MJ: Dietary nucleotides modulate antigen-specific type 1 and type 2 T cell responses in young C57BL/6 mice. Nutrition 16: 442-446, 2000.
65. Gollob JA, Veenstra KG, Jyonouchi, H, Kelly AM, Ferrieri P, Panka DJ, Altare F, Casanova JL, Fieschi C, Frank DA, and Mier JW. Impairment of STAT Activation by IL-12 in a Patient with Atypical Mycobacterial and Staphylococcal Infections. J. Immunol. 163: 4120-4126. 2000.
66. Jyonouchi H, Sun S, Winship T, and Kuchan MJ: Dietary nucleotides modulate type 1 vs. type 2 T cell responses against ovalbumin in young BALB/c mice. J. Nutr. 131: 1165-1170, 2001
67. Jyonouchi H: Immunomodulating actions of dietary nucleotides – any clinical implication? (Review). Recent Res. Develo. Allergy & Clin. Immunol. 1: 121-128, 2001.
68. Jyonouchi H, Sun S, K. Porter VA, and Cornfield DN: Polycyclic aromatic hydrocarbon (PAH) diol epoxides increase cytosolic Ca2+ concentrations of human small airway epithelial cells. Am J Res Cell Mol Biol. 25: 78-83. 2001
69. Jyonouchi H, Sun S, Le H.: Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J Neuroimmunol. 120: 170-179, 2001
70. Jyonouchi H, Sun S, Le H, and Rimell, FD: Evidence of dysregulated cytokine production by sinus lavage and peripheral blood mononuclear cells in patients with treatment-resistant chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg. 127: 1488-1494. 2001
71. Jyonouchi H, Sun S, and Itokazu N: Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorders. Neuropsychobiology 46: 76-84, 2002.
72. Jyonouchi H, Sun S, Whiship T, and Kuchan MJ: Dietary ribonucleotides increase antigen-specific type 1 T-helper cells in the regional draining lymph nodes in young BALB/cJ mice. Nutrition. 19: 41-46, 2003
73. Jyonouchi H, Sun S, Kelly A, and Rimell FL: The effects of exogenous interferon-γ (IFN-γ) on patients with treatment-resistant chronic rhinosinusitis and dysregulated IFN-γ production – A pilot study. Arch Otolaryngol Head Neck Surg 129: 563-569, 2003.
74. Jyonouchi H, Geng L, Ruby A, and Zimmerman-Bier, B: Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders (ASD): Their Relationship to Gastrointestinal (GI) Symptoms and Dietary Intervention. Neuropsychobiology 2005;51:77-85 (DOI: 10.1159/000084164)
75. Jyonouchi H, Geng L, Ruby A, Reddy C, and Zimmerman-Bier, B: Evaluation of possible association between gastrointestinal (GI) symptoms and cytokine production against common dietary proteins (DPs) in children with autism spectrum disorders (ASD). J. Pediatrics 146: 605-610, 2005.
76. Zimmerman AW, Jyonouchi H, Comi AM, Connors SL, Milstien S, Varsou A, and Heyes MP. CSF AND SERUM MARKERS OF INFLAMMATION IN AUTISM Ped Neurology 33: 195-201, 2005.
77. Jyonouchi H, Lien KW, Aguila H, Spinnato, GG, Sabharwal S, and Pletcher BA: Garre’s osteomyelitis and sarcoid dermatitis in a patient with DiGeorge syndrome. Eur. J. Pediatrics 2006; 165:370-374.
78. Ward CM, Jyonouchi H, Kotenko S, Patel R, Aguila H, McSherry G, Dashefsky B, and Holland SM: Adjunctive treatment of disseminated MAC infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 defect. Eur. J. Pediatr 166:981-985, 2007.
79. Ward CM, Geng L, and Jyonouchi H: Fetal sensitization to milk protein and wheat: milk protein and wheat-specific TNF-α production by umbilical cord blood cells and subsequent decline of TNF-α but not IL-10 production by peripheral blood mononuclear cells following dietary intervention. J. Pediatr Allergy Immunol 18: 276-280, 2007.
80. Jyonouchi H, Geng L, Toruner GA, Vinekar K, Feng D, Fitzgerald-Bocarsly P: Monozygous twins with microdeletion syndrome involving BTK, DDPA, and two other genes; evidence of intact dendritic cell development and TLR responses. Eur J Pediatr 67:317-321, 2008.
81. Jyonouchi H. Non-IgE mediated food allergy. Inflamm Allergy Drug Targets. 2008 3:173-80.
82. Jyonouchi H, Geng L, Cushing-Ruby A, Quraishi H: Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study. J. Neuroinflammation. 2008, 5:52
83. Jyonouchi H Food Allergy and Autism Spectrum Disorders: Is There a Link? Curr Allergy Asthma Reports 9:194-201, 2009.
84. Jyonouchi H, Geng L, Cushing-Ruby A, Monteiro I. Aberrant responses to TLR agonists in pediatric IBD patients: possible association with increased production of Th1/Th17 cytokines in response to candida, a luminal antigen. Ped Allergy Immunol 2010; 21: e744-755.
85. Timothy Buie, MD; Daniel B. Campbell, PhD; George J. Fuchs III, MD; Glenn T. Furuta, MD; Joseph Levy, MD; Judy Van de Water, PhD; Agnes H. Whitaker, MD; Dan Atkins, MD; Margaret L. Bauman, MD; Arthur L. Beaudet, MD; Edward G. Carr, PhD; Michael D. Gershon, MD; Susan L. Hyman, MD; Pipop Jirapinyo, MD; Harumi Jyonouchi, MD; Koorosh Kooros, MD; Rafail Kushak, MD, PhD; Pat Levitt, PhD; Susan E. Levy, MD; Jeffery D. Lewis, MD; Katherine F. Murray, BSN, RN; Marvin R. Natowicz, MD, PhD; Aderbal Sabra, MD, PhD; Barry K. Wershil, MD; Sharon C. Weston, MS, RD, LDN; Lonnie Zeltzer, MD; and Harland Winter, MD. Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With Autism Spectrum Disorder: A Consensus Report. Pediatrics 125:S1-18, 2010.
86. Jyonouchi, H. Autism spectrum disorders and allergy: Observation from a pediatric allergy/Immunology Clinic. Expert Review in Immunology. 6:397-411, 2010.
87. Jyonouchi H, Cui C, Geng L, Yin Z, Fitzgerald-Bocarsly P. Age-dependent changes in peripheral blood dendritic cell subsets in normal children and children with antibody deficiency syndrome. Eur J Pediatrics. 169: 1233-1239, 2010.
88. Jyonouchi H, Geng L, Streck D, and Toruner G. Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes. J. Neuroimmunol 15: 73-80, 2011.
89. Pedroza, LA, Kumar V, Sanborn KB, Mace EM, Niinikoski H, Nadeau K, deMoraes Vasconcelos D, Perez E, Jyonouchi S, Jyonouchi H, BanerjeePP, Ruuskanen O, Condino-Neto A, Orange JS. Autoimmune regulator (AIRE) contributes to dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), sleen tyrosine kinase (Syk), and Dectin-1. J. Allergy Clin Immunol 129:464-472, 2012.
90. Jyonouchi H, Geng L, Streck D, and Toruner G. Immunological characaterization and transcription profiling peripheral blood monocytes in children with autism spectrum disorders: Case Study J. Neuroinflammation 2012 Jan 7; 9(1): 4
1. Kincade PW, Jyonouchi H, Landreth KS, and Lee G: B-lymphocyte precursors in immunodeficient, autoimmune, and anemic mice. Immunol Rev 64:628-645, 1982.
3. Jyonouchi H and O’Neill Shigeoka A: Delayed-type Hypersensitivity. eMedicine March 9, 2009 (Review) www.emedicine.com/PED/topic558.htm
4. Jyonouchi H and O’Neill Shigeoka A: Hyperimmunoglobulinemia E (Job) Syndrome. eMedicine April 1, 2009 (Review) www.emedicine.com/PED/topic1075.htm
5. Agrawal R and Jyonouchi H : Complement Deficiency eMedicine November 9, 2007 www.emedicine.com/ped/topic447.htm
1. Kincade PW, Jyonouchi H, Landreth KS, and Lee G: Microenvironmental and age influences on development of B lymphocyte lineage cells. In "Progress of Immunology", T Tada and Y Yamamura (eds), Academic Press Japan, Inc. pp 645-655, 1984.
4. Jyonouchi H: Immunological issues in patients with autism spectrum disorders. (Review) To be included in “Neuropsychiatric Disorders and Infection” (Ed: SH Fatemi), Martin Dunitz & Parthenon Publishing, Taylor & Francis Medical Books. Jan. 2005 pp 187-197.
5. Jyonouchi H, Geng L, Ruby A, and Reddy C: Suboptimal responses to dietary intervention in children with autism spectrum disorders and Non-IgE mediated food allergy. In: ‘Autism Research Advances’ (Editor: L. B. Zhao), pp. 169-184, Nova Science Publishers, Inc. 2007.
6. Jyonouch H Possible impact of innate immunity on autism (Editor: A. Chauhan), Taylor & Francis Group LLC. pp 248-265, 2009
7. Jyonouchi H, Geng L, Kattouf P, Streck D, and Toruner G. Possible impaired oral tolerance in ASD children with food protein induced enterocolitis syndrome (FPIES): Difference in innate and adaptive immune responses in ASD children recovered from FPIES in comparison with non-ASD/FPIES and ASD/non-FPIES children In “Neurodevelopmental Journey from Genes to behavior” Ed: Eapen V. Online open-access book InTech – Published in August, 2011. ISBN 975-953-307-493-1
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