Harumi Jyonouchi, MD

 

Harumi Jyonouchi, MD

Associate Professor


 

Dr. Harumi Jyonouchi received her medical training at the Yokohama City University School of Medicine, Yokohama, Japan and then completed training in Pediatrics at Fujigaoka Hospital, Showa University, Japan. She then served as a research fellow at Sloan-Kettering Institute for Cancer Research in New York and then as a Senior Research Scientist at the Oklahoma Medical Research Foundation. She completed a fellowship in Pediatric Immunology at Oklahoma Children's Memorial Hospital, and did additional training in Allergy/Immunology at All Children's Hospital, St. Petersburg, Florida, where she joined the faculty as an Assistant Professor of Pediatrics and the Assistant Director of the Immunoparameter Laboratory. She went on to become an Associate Professor of Medicine at the University of Minnesota and served as the co-director for the Allergy/Immunology fellowship. She has been in the Department of Pediatrics at NJMS since 2002. She is the recipient of a number of honors and awards, and has served on NIH grant review committees and Editorial Boards. She is currently the Chief Editor of the Pediatrics Section of eMedicine. She has had continuous grant support since 1989 and is the author of over 100 published peer-reviewed articles and chapters. Her research interests include: neuro-immune interactions and epigenetic regulation in children with autism spectrum disorders, innate immune abnormalities in patients with mucosal inflammation of the airway (asthma) and the GI tract, and non-IgE mediated food allergy

 

PUBLICATIONS:

Peer-reviewed articles:

1. Jyonouchi H and Yamaguchi M: A case of neonatal hyperbilirubinemia secondary due to Rh incompatibility. (in Japanese) J Pediatr Practice 40:2008-2011, 1977.

2. Jyonouchi H, Yanagisawa N, and Yamaguchi M: Hereditary spherocytosis requiring exchange transfusion during the neonatal period with special reference to the morphological studies of HS erythrocytes. (in Japanese) Acta Paediatr JPN 20:654-658, 1978.

3. Jyonouchi H, Yanagisawa N, and Soneda Y: A case of neonatal gastric rupture complicating with congenital diaphragm eventration. (in Japanese) Jap J Pediatr 31:395-398, 1978.

4. Yamaguchi M, Shioda S, Jyonouchi H, Yamada K, and Ishikawa A: Infectious mononucleosis in siblings. (in Japanese) Jap J Pediatr 31:2431-2435, 1978.

5. Jyonouchi H, Shioda S, Yamaguchi M, Yamada K, Ishikawa A, and Ito M: Clinical studies of infectious mononucleosis. (in Japanese) Jap J Pediatr 31:2436-2442, 1978.

6. Yamaguchi M, Jyonouchi H, Sata T, Yokoi K, Yanagisawa N, Yamada K, and Ishikawa A: Clinical and laboratory studies on mycoplasma pneumonia. (in Japanese) Pediatrics of Japan 19:313-319, 1978.

7. Jyonouchi H, Yanagisawa N, Ishikawa A, and Ishihara K: One pedigree of hereditary spherocytosis (HS): Scanning electron microscopic studies of HS erythrocytes in vitro. (in Japanese) J Clin Electron Microsc 12:91-105, 1979.

8. Jyonouchi H, Kurokawa Y, and Ishidawa A: Studies of RBC 2, 3-DPG in MCLS. (in Japanese) Igaku No Ayumi 109:86-88, 1979.

9. Jyonouchi H: Studies of RBC 2, 3-DPG levels in Childhood. 1. Studies on healthy children and low birth weight babies. (in Japanese) J Showa Med Assoc 39:373-379, 1979.

10. Jyonouchi H, Yanagisawa N, Ishikawa A, and Ishihara K: Scanning electromicroscopic studies on the erythrocytes of hereditary spherocytosis III. Effect of propranolol-a beta blocking agent on the erythrocyte of hereditary spherocytosis. J Clin Electron Microsc 12:5-6, 1979.

11. Yamaguchi J, Isoyama K, Fujita Y, Jyonouchi H, Hanawa H, Yanagisawa N, Yamada K, and Ishikawa A: Clinical studies on the complication of mycoplasma pneumonia. (in Japanese) Jap J Infect Dis 54:173-179, 1980.

12. Jyonouchi H, Yokoi K, and Ishikawa A: A congenital bronchobiliary fistula. Acta Paediatr JPN (in Japanese) 84:1270-1277, 1980.

13. Yamaguchi M and Jyonouchi H: Two cases of male Turner Syndrome. J Showa Med Assoc 40:76-82, 1980.

14. Jyonouchi H and Yoshio T: A case of vascular purpura complicating with remarkable facial edema. (in Japanese) Pediatrics of Japan 21:1981.

15. Jyonouchi H, Kincade PW, Good RA, and Fernandes G: Reciprocal transfer of abnormalities in clonable B lymphocytes and myeloid progenitors between NZB and DBA/2 mice. J Immunol 127:1232-1235, 1981.

16. Jyonouchi H, Kincade PW, and Good RA: Immunosuppression of marrow B lymphocytes by administration of Corynebacterium parvum in mice. J Immunol 127:2502-2507, 1981.

17. Jyonouchi H, Cyong JC, Fernandes G, Day NK, and Good RA: Alteration of murine serum lipase activity after allogeneic bone marrow transplantation. J Clin Immunol Immunopathol 22:94-104, 1982.

18. Jyonouchi H, Kincade PW, Landreth KS, Lee G, Good RA, and Gershwin ME: Age-dependent deficiency of B lymphocyte lineage precursors in NZB mice. J Exp Med 155:1665-1678, 1982.

19. Jyonouchi H and Kincade PW: Changes in B lineage cell populations in liver and spleen of neonatal mice. J Immunol 130:1616-1621, 1983.

20. Jyonouchi H, Kincade PW, Good RA, and Gershwin ME: B lymphocyte lineage cells in newborn and very young NZB mice. Evidence for regulatory disorders affecting B cell formation. J Immunol 131:2219-2225, 1983.

21. Jyonouchi H, Kincade PW, and Misra HP: Analysis of the effects of erythrocytes on mitogen-dependent clonal proliferation of murine B lymphocytes. Cell Immunol 83:189-198, 1984.

22. Jyonouchi H and Kincade PW: Precocious and enhanced functional maturation of B lineage cells in New Zealand Black mice during embryonic development. J Exp Med 159:1277-1282, 1984.

23. Jyonouchi H, Kincade PW, and Good RA: Age-dependent changes in B lymphocyte lineage cell populations of autoimmune prone BXSB mice. J Immunol 134:858-864, 1985.

24. Jyonouchi H, Kimmel MD, Lee G, Kincade PW, and Good RA: Humoral factors in very young NZB mice that enhance the maturation of normal B cell precursors. Partial Purification and characterization. J Immunol 135:1891-1899, 1985.

25. Jyonouchi H, Voss RM, and Good RA: IL-1 like activities present in murine amniotic fluid. A significantly larger amount of IL-1 like activity is present in the amniotic fluid of autoimmune NZB mice. J Immunol 138:3300-3307, 1987.

26. Jyonouchi H, Voss RM, and Good RA: The presence of autoantibodies specific for NZB serum factors in adult NZB mice and the establishment of monoclonal antibodies against these humoral factors. Cell Immunol 113:158-174, 1988.

27. Jyonouchi H, Voss RM, and Good RA: Up-regulation and down-regulation of cell surface and mRNA expression of CD5 antigen by various humoral factors on murine 70Z/3 pre-B cell leukemia cell line. IL-4 down-regulates CD5 antigen expression. Cell Immunol 130, 66-78, 1990.

28. Jyonouchi H, Voss RM, and Good RA: NZB serum factor (NZB-SF): B precursor cell maturation factor identified in murine lupus. I. Identification of 60-kDa glycoprotein as the major component from both spleen cell supernatant and serum. Cell Immunol 132:223-235, 1991.

29. Jyonouchi H, Voss RM, and Good RA: NZB serum factor (NZB-SF) - B precursor cell maturation factor: II, In vivo effects of NZB-SF or mAb against NZB SF on B lineage cell population. J Clin Immunol Immunopathol 59:388-397, 1991.

30. Jyonouchi H, Voss RM, Krishna S, Urval K, Sjahli H, Welty PB, and Good RA: Soluble Fce R II levels in normal children and patients with immunodeficiency diseases. J Allergy Clin Immunol 87:965-970, 1991.

31. Jyonouchi H, Hill RJ, Tomita Y, and Good RA: Studies of immunomodulating actions of carotenoids. I. Effects of b-carotene and astaxanthin on murine lymphocyte functions and cell surface marker expression in in vitro culture system. Nutr Cancer 16:93-105, 1991.

32. Jyonouchi H, Voss RM, and Good RA: Zn depletion modifies CD5 expression by 7OZ/3 murine pre-B leukemia cell line. Proc Soci Exp Biol Med 198:818-825, 1991.

33. Jyonouchi H, Hill RJ, and Good RA: RNA/nucleotides enhances antibody production in vitro and is moderately mitogenic to murine spleen lymphocytes. Proc Soci Exp Biol Med 200:101-108, 1992.

34. Jyonouchi H, Zhang L, and Tomita Y: Studies of Immunomodulating Actions of Carotenoids. II. Astaxanthin enhances in vitro antibody production to T-dependent antigens without facilitating polyclonal B cell activation. Nutr Cancer 19:269-280, 1993.

35. Jyonouchi H, Zhang L, and Tomita Y: Studies of immunomodulating actions of RNA/nucleotides. RNA/nucleotides enhance in vitro Ig production by human peripheral blood mononuclear cells in response to T dependent stimuli. Ped Res 33:458-465, 1993.

36. Jyonouchi H, Zhang L, Georgieff M, and Tomita Y: Immunomodulating actions of nucleotides. Enhancement of Ig production by human cord blood lymphocytes. Ped Res 34:565-571, 1993

37. Jyonouchi H, Hill RJ, Voss RM, and Ishii E: Immunomodulating actions of RNA and nucleotides on murine lymphocytes in vitro. Augmentation of antibody production to T dependent antigens and expansion of T helper cells. J Nutr Immunol 2(2):5-24, 1993.

38. Tomita Y, Jyonouchi H, Engelman R, Day NK, and Good RA: Preventive action of carotenoids on the development of autoimmunity in MRL-lpr/lpr mice. J Autoimmunity 16:95-102, 1993.

39. Jyonouchi H, Zhang L, and Tomita Y: RNA/nucleotides enhance in vitro antibody and immunoglobulin production to T-dependent antigen but do not facilitate polyclonal B cell activation in both normal and autoimmune-prone NZB strains of mice. J Nutr Immunol 2 (3): 5-22, 1993.

40. Jyonouchi H, Zhang L, Gross M, and Tomita Y.: Immunomodulating actions of carotenoid: Enhancement of in vivo and in vitro antibody (Ab) production to T-dependent antigens (TD-Ag). Nutr Cancer 21:47-58, 1994.

41. Jyonouchi H: Nucleotide actions on humoral immune responses. J Nutr 124:138S-143S, 1994.

42. Loechelt BJ, Egeler M, Filipovich AH, Jyonouchi H, and Shapiro RS: Immunosuppression: an alternative maintenance therapy for familial hemophagocytic lymphohistiocytosis (FEL). Med Ped Oncol 22:325-328, 1994.

43. Jyonouchi H, Zhang L, Tomita Y, and Yokoyama H: Nucleotide-free diet impairs T-helper cell functions for antibody production in normal C57Bl/6 mice. J Nutr 124: 475-484, 1994.

44. Jyonouchi H, Sun S, and Gross MD: Biological actions of carotenoids: astaxanthin, a carotenoid without vitamin A activity, enhances in vitro Ig production by human peripheral blood mononuclear cells. Nutr Cancer 23:171-183, 1995

45. Jyonouchi H, Zhang L, Sun S, and Yokoyama H: Polynucleotides can compensate for impaired T-dependent antibody production induced by a nucleotide-free diet both in vivo and in vitro in C57Bl/6 mice, but mononucleotide/nucleoside mixture (OGVI) is effective only in vivo. J. Nutr. 125:1578-1586, 1995

46. Jyonouchi H, Sun S, Tomita Y, and Gross MD: Astaxanthin, a carotenoid without vitamin A activity, augments antibody responses with T-helper clones in response to suboptimal Ag challenges. J. Nutr. 125:2483-2492, 1995.

47. Jyonouchi H, Sun S, Goodman D, Yokoyama H, and Sato S: Dietary fatty acid modulates actions of nucleotides on humoral immune responses. Nutrition 11:437-443, 1995.

48. Jyonouchi H, Sun S, and Tomita Y: Actions of ß-carotene on T-helper cell functions for antibody production. J. Nutr. Immunol. 3 (4): 21-34, 1995.

49. Jyonouchi H and Sun S.: Effects of Orally supplemented mononucleotide mixture on T-dependent humoral immunity in C57BL/6 mice fed a nucleotide-free diet. J. Nutr. 126:1586-1593, 1996.

50. Jyonouchi H, Sun S, and Sato S: A nucleotide-free diet suppresses antigen-driven cytokine production by primed T cells: effects of supplemental nucleotides and dietary fatty acids. Nutrition 12: 608-615, 1996.

51. Jyonouchi H, Sun S, Mizokami M, and Gross MD: Effects of Various Carotenoids on Cloned, Effector-stage T-helper Cell Activity. Nutr. Cancer 26:313-324, 1996

52. Jyonouchi H and Sun S: The actions of polynucleotides on effector stage cloned T-helper cells differ in each T-helper cell subset and depend on antigen concentration. J. Nutr. 127:411-417, 1997.

53. Jyonouchi H, Sun S, Mizokami M, and Ingbar DH: Cell density and antioxidant vitamins determine the effects of hyperoxia on proliferation and death of MDCK epithelial cells. Nutr Cancer 28:115-124, 1997.

54. Jyonouchi H, Sun S, Kennedy CA, Kajander, KC, and Rimell FL: IgG antibody levels in the sinus, ear, and airway in a rabbit model of sinusitis with Bacteroides Archives of Otolaryngology-Head and Neck Surgery. 124:767-772, 1998

55. Jyonouchi H, Sun S, Chareancholvanich S, and Ingbar DH: The effects of hyperoxic injury and antioxidant vitamins on death and proliferation of human small airway epithelial cells. Am. J. Resp. Cell Mol. Biol. 19:426-436, 1998.

56. Jyonouchi H, Sun S, Iijima K., Wong M., and Hecht, SS.: Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositol. Carcinogenesis. 20: 139-145, 1999.

57. Kennedy CA, Jyonouchi H, Kajander KC, Sun S, and Rimell FL: Middle ear changes associated with chronic anaerobic sinusitis in rabbits. Laryngoscope 109: 498-503, 1999.

58. Jyonouchi H, Sun S, Kennedy CA, Roche A, Kajander KC, Miller J, Germaine G, , and Rimell FL: The localized sinus inflammation in a rabbit sinusitis model induced by Bacteroides fragilis is accompanied by rigorous immune responses. Otolaryngology-Head and Neck Surgery. 120: 869-875, 1999.

59. Iijima K, Sun S, Cyong JC, and Jyonouchi H: Juzen-Taiho-To, a Japanese herbal medicine, modulates type 1 and type 2 T cell responses in old BALB/c mice. Am J Chinese Med 17:191-203, 1999.

60. Jyonouchi H. Airway Epithelium and apoptosis. Apoptosis 4:407-417, 1999.

61. Jyonouchi H, Sun S, Iijima K, and Gross MD: Anti-tumor activity of astaxanthin and its mode of action. Nutr. Cancer 36: 59-65, 2000.

62. Jyonouchi H, Sun S, and Rimell FL: Cytokine production by sinus lavage, bronchial lavage, and blood mononuclear cells in chronic sinusitis with or without atopy. Archives of Otolaryngology-Head and Neck Surgery 126: 522-528, 2000

63. Jyonouchi H, Sun S, Kennedy CA, and Rimell FL: Interferon- levels in the sinus, ear, and airway in a rabbit sinusitis model induced by Bacteroides inoculation. Archives of Otolaryngology-Head and Neck Surgery 126: 529-532, 2000

64. Jyonouchi H, Sun S, Abiru T, Whinship, T, and Kuchan, MJ: Dietary nucleotides modulate antigen-specific type 1 and type 2 T cell responses in young C57BL/6 mice. Nutrition 16: 442-446, 2000.

65. Gollob JA, Veenstra KG, Jyonouchi, H, Kelly AM, Ferrieri P, Panka DJ, Altare F, Casanova JL, Fieschi C, Frank DA, and Mier JW. Impairment of STAT Activation by IL-12 in a Patient with Atypical Mycobacterial and Staphylococcal Infections. J. Immunol. 163: 4120-4126. 2000.

66. Jyonouchi H, Sun S, Winship T, and Kuchan MJ: Dietary nucleotides modulate type 1 vs. type 2 T cell responses against ovalbumin in young BALB/c mice. J. Nutr. 131: 1165-1170, 2001

67. Jyonouchi H: Immunomodulating actions of dietary nucleotides – any clinical implication? (Review). Recent Res. Develo. Allergy & Clin. Immunol. 1: 121-128, 2001.

68. Jyonouchi H, Sun S, K. Porter VA, and Cornfield DN: Polycyclic aromatic hydrocarbon (PAH) diol epoxides increase cytosolic Ca2+ concentrations of human small airway epithelial cells. Am J Res Cell Mol Biol. 25: 78-83. 2001

69. Jyonouchi H, Sun S, Le H.: Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J Neuroimmunol. 120: 170-179, 2001

70. Jyonouchi H, Sun S, Le H, and Rimell, FD: Evidence of dysregulated cytokine production by sinus lavage and peripheral blood mononuclear cells in patients with treatment-resistant chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg. 127: 1488-1494. 2001

71. Jyonouchi H, Sun S, and Itokazu N: Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorders. Neuropsychobiology 46: 76-84, 2002.

72. Jyonouchi H, Sun S, Whiship T, and Kuchan MJ: Dietary ribonucleotides increase antigen-specific type 1 T-helper cells in the regional draining lymph nodes in young BALB/cJ mice. Nutrition. 19: 41-46, 2003

73. Jyonouchi H, Sun S, Kelly A, and Rimell FL: The effects of exogenous interferon-γ (IFN-γ) on patients with treatment-resistant chronic rhinosinusitis and dysregulated IFN-γ production – A pilot study. Arch Otolaryngol Head Neck Surg 129: 563-569, 2003.

74. Jyonouchi H, Geng L, Ruby A, and Zimmerman-Bier, B: Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders (ASD): Their Relationship to Gastrointestinal (GI) Symptoms and Dietary Intervention. Neuropsychobiology 2005;51:77-85 (DOI: 10.1159/000084164)

75. Jyonouchi H, Geng L, Ruby A, Reddy C, and Zimmerman-Bier, B: Evaluation of possible association between gastrointestinal (GI) symptoms and cytokine production against common dietary proteins (DPs) in children with autism spectrum disorders (ASD). J. Pediatrics 146: 605-610, 2005.

76. Zimmerman AW, Jyonouchi H, Comi AM, Connors SL, Milstien S, Varsou A, and Heyes MP. CSF AND SERUM MARKERS OF INFLAMMATION IN AUTISM Ped Neurology 33: 195-201, 2005.

77. Jyonouchi H, Lien KW, Aguila H, Spinnato, GG, Sabharwal S, and Pletcher BA: Garre’s osteomyelitis and sarcoid dermatitis in a patient with DiGeorge syndrome. Eur. J. Pediatrics 2006; 165:370-374.

78. Ward CM, Jyonouchi H, Kotenko S, Patel R, Aguila H, McSherry G, Dashefsky B, and Holland SM: Adjunctive treatment of disseminated MAC infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 defect. Eur. J. Pediatr 166:981-985, 2007.

79. Ward CM, Geng L, and Jyonouchi H: Fetal sensitization to milk protein and wheat: milk protein and wheat-specific TNF-α production by umbilical cord blood cells and subsequent decline of TNF-α but not IL-10 production by peripheral blood mononuclear cells following dietary intervention. J. Pediatr Allergy Immunol 18: 276-280, 2007.

80. Jyonouchi H, Geng L, Toruner GA, Vinekar K, Feng D, Fitzgerald-Bocarsly P: Monozygous twins with microdeletion syndrome involving BTK, DDPA, and two other genes; evidence of intact dendritic cell development and TLR responses. Eur J Pediatr 67:317-321, 2008.

81. Jyonouchi H. Non-IgE mediated food allergy. Inflamm Allergy Drug Targets. 2008 3:173-80.

82. Jyonouchi H, Geng L, Cushing-Ruby A, Quraishi H: Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study. J. Neuroinflammation. 2008, 5:52

83. Jyonouchi H Food Allergy and Autism Spectrum Disorders: Is There a Link? Curr Allergy Asthma Reports 9:194-201, 2009.

84. Jyonouchi H, Geng L, Cushing-Ruby A, Monteiro I. Aberrant responses to TLR agonists in pediatric IBD patients: possible association with increased production of Th1/Th17 cytokines in response to candida, a luminal antigen. Ped Allergy Immunol 2010; 21: e744-755.

85. Timothy Buie, MD; Daniel B. Campbell, PhD; George J. Fuchs III, MD; Glenn T. Furuta, MD; Joseph Levy, MD; Judy Van de Water, PhD; Agnes H. Whitaker, MD; Dan Atkins, MD; Margaret L. Bauman, MD; Arthur L. Beaudet, MD; Edward G. Carr, PhD; Michael D. Gershon, MD; Susan L. Hyman, MD; Pipop Jirapinyo, MD; Harumi Jyonouchi, MD; Koorosh Kooros, MD; Rafail Kushak, MD, PhD; Pat Levitt, PhD; Susan E. Levy, MD; Jeffery D. Lewis, MD; Katherine F. Murray, BSN, RN; Marvin R. Natowicz, MD, PhD; Aderbal Sabra, MD, PhD; Barry K. Wershil, MD; Sharon C. Weston, MS, RD, LDN; Lonnie Zeltzer, MD; and Harland Winter, MD. Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With Autism Spectrum Disorder: A Consensus Report. Pediatrics 125:S1-18, 2010.

86. Jyonouchi, H. Autism spectrum disorders and allergy: Observation from a pediatric allergy/Immunology Clinic. Expert Review in Immunology. 6:397-411, 2010.

87. Jyonouchi H, Cui C, Geng L, Yin Z, Fitzgerald-Bocarsly P. Age-dependent changes in peripheral blood dendritic cell subsets in normal children and children with antibody deficiency syndrome. Eur J Pediatrics. 169: 1233-1239, 2010.

88. Jyonouchi H, Geng L, Streck D, and Toruner G. Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes. J. Neuroimmunol 15: 73-80, 2011.

89. Pedroza, LA, Kumar V, Sanborn KB, Mace EM, Niinikoski H, Nadeau K, deMoraes Vasconcelos D, Perez E, Jyonouchi S, Jyonouchi H, BanerjeePP, Ruuskanen O, Condino-Neto A, Orange JS. Autoimmune regulator (AIRE) contributes to dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), sleen tyrosine kinase (Syk), and Dectin-1. J. Allergy Clin Immunol 129:464-472, 2012.

90. Jyonouchi H, Geng L, Streck D, and Toruner G. Immunological characaterization and transcription profiling peripheral blood monocytes in children with autism spectrum disorders: Case Study J. Neuroinflammation 2012 Jan 7; 9(1): 4

Review articles:

1. Kincade PW, Jyonouchi H, Landreth KS, and Lee G: B-lymphocyte precursors in immunodeficient, autoimmune, and anemic mice. Immunol Rev 64:628-645, 1982.

2. Kincade PW, Jyonouchi H, Landreth KS, Engelhart D, Beare NH, Lee G, and Good RA: Factors affecting normal and malignant B lymphocyte precursors. Curr Top Microbial Immunol 113:104-108, 1984.

3. Jyonouchi H and O’Neill Shigeoka A: Delayed-type Hypersensitivity. eMedicine March 9, 2009 (Review) www.emedicine.com/PED/topic558.htm

4. Jyonouchi H and O’Neill Shigeoka A: Hyperimmunoglobulinemia E (Job) Syndrome. eMedicine April 1, 2009 (Review) www.emedicine.com/PED/topic1075.htm

5. Agrawal R and Jyonouchi H : Complement Deficiency eMedicine November 9, 2007 www.emedicine.com/ped/topic447.htm

Chapters:

1. Kincade PW, Jyonouchi H, Landreth KS, and Lee G: Microenvironmental and age influences on development of B lymphocyte lineage cells. In "Progress of Immunology", T Tada and Y Yamamura (eds), Academic Press Japan, Inc. pp 645-655, 1984.

2. Kincade PW and Jyonouchi H: B cell differentiation. In "Iwanami Immunology Series 4". "Evolution and differentiation of the immune system." RA Good (ed), Iwanami Shoten, pp 189-214, 1986.

3. Filipovich AH, Gross T, Jyonouchi H, and Shapiro RS: Immune-mediated hematologic and oncologic disorders, including Epstein-Bar virus infection. In “Immunologic Disorders in infants and children”, ER Stiehm (ed), W. B. Saunders., Philadelpha. pp855-888, 1996.

4. Jyonouchi H: Immunological issues in patients with autism spectrum disorders. (Review) To be included in “Neuropsychiatric Disorders and Infection” (Ed: SH Fatemi), Martin Dunitz & Parthenon Publishing, Taylor & Francis Medical Books. Jan. 2005 pp 187-197.

5. Jyonouchi H, Geng L, Ruby A, and Reddy C: Suboptimal responses to dietary intervention in children with autism spectrum disorders and Non-IgE mediated food allergy. In: ‘Autism Research Advances’ (Editor: L. B. Zhao), pp. 169-184, Nova Science Publishers, Inc. 2007.

6. Jyonouch H Possible impact of innate immunity on autism (Editor: A. Chauhan), Taylor & Francis Group LLC. pp 248-265, 2009

7. Jyonouchi H, Geng L, Kattouf P, Streck D, and Toruner G. Possible impaired oral tolerance in ASD children with food protein induced enterocolitis syndrome (FPIES): Difference in innate and adaptive immune responses in ASD children recovered from FPIES in comparison with non-ASD/FPIES and ASD/non-FPIES children In “Neurodevelopmental Journey from Genes to behavior” Ed: Eapen V. Online open-access book InTech – Published in August, 2011. ISBN 975-953-307-493-1