Welcome to the Hematopoietic Stem Cell Biology and Dysfunction web site.
The purpose of this course is to provide students with an understanding of the molecular mechanism of hematological disorders. The intent is to give students the scientific and clinical background to pursue different careers such as dental, medicine, basic research, clinical coordinator and translational science. The lectures will be taught by expert hematologists.
Course Schedule
General Information
Purpose:
The purpose of this course is to provide students with an understanding of how dysfunctions in the bone marrow microenvironment and the hematopoietic stem cells could result in clinical abnormalities (diseases). In addition, students will learn how bench research leads to solving hematological problems. All students will benefit from this course: those applying to dental and medical school need the clinical background information and graduate student will begin to appreciate translational science.
Hematology has been at the forefront of advances of stem cells from non-bone marrow sources. The subject of hematology involves studies of bone marrow-resident stem
cells and the influences of the microenvironment and the immune system on
homeostasis of the bone marrow. An understanding of the aberrant stem cell
mechanisms, which underlie hematological diseases will provide paradigms for
further study of other stem cells and their application in clinical medicine.
This course will illustrate how our increasing knowledge of the biology of
hematopoietic and, other bone marrow-derived stem cells can provide new insights
into the clinical features of hematologic disease.
The following is an example of how each lecture is structured in the context of discussions on the
pathophysiology of the hematological disorder:
- Lectures describing the basic science of the disease and the evolution of
new drug targets.
- The outcome of clinical trials with the advent of drug resistance.
- Lectures on how the bedside outcome leads back to the bench.
The course will have didactic lectures and discussions related to the
lecture material. There will be three exams, each with equal weight.
Suggested
Text:
Clinical Hematology, Edited by Neal S. Young, Stanton L.
Gerson and Katherine A. High. Mosby Elsvier, ISBN 0-323-01908-0
Printing Instructions:
When printing the
presentations try to select grayscale to conserve the
color ink. Also, select both sides of the paper and multiple slides on a
single page.
Faculty Contact
Course Director:
Anupama Nehra,
M.D.
E-mail: an607@cinj.rutgers.edu
Telephone: (973) 972
6257 (Main Hematology Office) |
