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Course Descriptions

BIOCHEMISTRY AND MOLECULAR BIOLOGY

CELL BIOLOGY AND MOLECULAR MEDICINE

DIVISIONAL COURSES

BIOINFORMATICS

NEUROSCIENCE

MICROBIOLOGY AND MOLECULAR GENETICS

MOLECULAR PATHOLOGY AND IMMUNOLOGY

ORAL BIOLOGY

PHARMACOLOGY AND PHYSIOLOGY

 

BIOCHEMISTRY AND MOLECULAR BIOLOGY

BIOC5000 Thesis Research. 5 or 10 cr. (5 credits for part time students and 10 credits for full time students)

Taken after completion of credit requirements. Fall and Spring.

BIOC501A Medical Biochemistry. 5 cr. Fall

Given in the first semester, this course will review intermediary metabolism, molecular biology and biochemical pathology. The Lecture series, conferences and examinations are identical to those taken by medical students.

BIOC502A-C Biochemical Techniques. 2 cr. Fall and Spring

This course entails a laboratory rotation. Students will be expected to participate in the design and execution of an original experiment. Within the first 2 years of graduate school in the Department of Biochemistry and Molecular 3 rotations are required.

BIOC5012 Effective Proposal Writing Strategies. 1cr. Spring

This course is for second year students who have to write a proposal for their qualifying exams. The objective is to educate students on effective grant proposal writing strategies. The course would cover proposal components, objectives, review process, evaluation methods, as well as style and format proposals from different funding agencies such as NIH, NSF, and NJCCR.

BIOC5030 Pr otein dynamics in health and disease 3 cr. Fall

This lecture-based course will focus on the biogenesis, structure and localization of proteins under normal physiological conditions as well as in disease states.  Emphasis will be placed on experimental approaches used to elucidate protein structure-function relationships, to identify novel disease markers or targets, and to rationally develop small molecule or peptide therapeutics.  The course is required for Ph.D. candidates in the Department of Biochemistry, and is also open to Ph.D. candidates from other departments and to Masters Students.  Prerequisite: Fall semester of the Core Course or Molecular & Genetic Medicine (MGM).

BIOC5070 Biochemistry of Nucleic Acids. 4 cr. Fall

This course covers many aspects of structural and biosynthetic properties of DNA, RNA and proteins. In addition, regulatory mechanisms governing biosynthesis of these macromolecules in prokaryotic and eukaryotic systems is also covered.

BIOC508A Current Topics in Biochemistry. 2 cr. Spring

Faculty members in the department will discuss their areas of research interest.

BIOC5100 Molecular Oncology. 2 cr. Spring

The course will review the molecular basis of carcinogenesis the metabolism of cancer cells and changes in genes and gene transcription. Biochemical aspects of cancer chemotherapy will be discussed.

BIOC5170 Molecular Methods in Biochemistry . 3 cr. Fall

A course providing theory and practical demonstrations for the major techniques used in biochemistry and molecular biology .

BIOC5200 Regulation of Gene Expression. 2 cr. Spring

This course provides an overview of the regulation of transcription in procaryotes and eukaroytes with major emphasis on techniques and the regulation of gene transcription in eukaryotic cells.

BIOC5220 Signaling Mechanisms in Biological Systems. 2 cr. Spring

This course examines the molecular events that cells use to process a variety of extracellular signals and convert them into biological responses. The focus is on common signaling events that can be described in molecular detail and provide an integrative approach to regulation and signal transduction.

BIOC5240 Molecular Biology of the News. 1 cr. Spring --
only occurs in Spring of odd years (2009, 2011 etc).  

The objective of this course is to discuss fundamental biochemical principles underlying recent developments that have received attention in the lay press (e.g., New York Times, Time Magazine).

BIOC5270 Proteolysis. 1 cr. Spring

The objectives of the course are to understand (1) the mechanisms by which proteolytic enzymes regulate cellular function and (2) the experimental strategies used to elucidate these mechanisms. Topics include the enzymology and regulation of the proteosome/ubiquitin pathway; proteolysis and the cell cycle; role of proteolysis in apoptotic signaling. Prerequisites: Biochemistry and Molecular Biology and Signaling Mechanisms in Biological Systems.

BIOC5290 Critical Reading of the Literature. 3 cr. Fall

The objective of this course is to introduce students to the primary literature. It helps students develop skills in addressing papers and understanding the information contained, and encourages an attitude of constructive skepticism in reading the scientific literature. Given in the first semester.

BIOC591A Seminar in Biochemistry. 1 cr. Fall and Spring

Seminar presentations based on current research publications.

BIOC N5002 Introduction to Genomics, Proteomics and Bioinformatics 2 cr Fall

This course covers basic concepts in genomics, molecular evolution, genetic variation, gene analysis, DNA microarray, proteomics, and bioinformatics.


BIOC 5003 Advances in Genomics, Proteomics, and Bioinformatics 2 cr Spring

The goal of this course is to discuss current techniques and research trends in genomics, proteomics, and bioinformatics by reading and presenting recent literatures. 

BIOCH 5007Q Foundations in Biochemistry and Molecular Biology 1 cr Spring

The objective of this course is to provide a historical overview of selected fundamental molecular biological and biochemical principles that underlie modern biological science. Lectures will be based on review articles in such as the Annual Review series, the Trends series, and the Journal of Biological Chemistry. Evaluation will be by means of a take-home essay.

CELL BIOLOGY AND MOLECULAR MEDICINE

CBMM5000 Thesis Research. 5 or 10 cr. (5 credits for part time students and 10 credits for full time students)

Taken after completion of credit requirements.

CBMM N5001 Basic Histology. 3 cr. Fall

This course covers basic histology of human/mammalian tissues and organs.  Lecture presentations and student study will involve the use of virtual microscopy (VM) of histological preparations.  The course is designed for students starting graduate work in biomedical sciences and those employed as biology teachers or laboratory technicians working with biological/pathological tissues.  Although it is primarily designed for Masters students, doctoral students (other than those in the department of Cell Biology & Molecular Medicine) may take this course for credit with added requirements in the form of extra assignments.  The course will meet for 15 evening sessions, once per week for 3 hours each session.

CBMM 5002 Practical Approaches for Studying Protein Function. 2 cr. Fall

Fourteen lectures will be given by different investigators, each regarding a different technology and how it is applied in the laboratory to study the functions of a protein. Hour 1 will be lecture format; Hour 2 will be student presentations and discussion of the assignment. Weekly assignments will count for 60% of the grade with a final examination counting for the other 40%.

CBMM5010 Human Gross Anatomy. 6 cr. Fall

Lectures, dissections, demonstrations and conferences emphasize structure-function relationships, surface anatomy and clinical applications. The course is open to matriculated graduate students who are interested in an overview of human anatomy.

CBMM 5020 Developmental Biology. 2 cr. Spring

This course is designed for beginners in the field of developmental biology. It is divided into three parts: basics of developmental biology; technologies (knockouts, ES cells, and genomics); integrated view on signaling and techniques applied to an organ during development.

CBMM5060 Cell and Tissue Biology 4 cr . Spring

The basic structure of human cells, tissues, and organs are studied with regard to their functional activities. Cellcell and celltissue interactions will be examined as they pertain to signal transduction pathways and the cell/tissue response to abnormal physiological stimuli.

CBMM5068Q Understanding the Molecular Mechanisms of Disease: From Yeast to Humans. 3 cr. Spring

This is an introductory course to review major model organisms studied in modern biomedical research. We will discuss how these organisms are being used to unravel the molecular causes underlying several major diseases (3 credit hours). The course wick highlight the advantages and disadvantages if each model organism and introduce students to in vivo analysis of specific disease states and pathways deregulated in disease.

CBMM 5070Q Histology Techniques. 1 cr.Spring

This course is designed for graduate students in biomedical sciences interested in learning basic skills to produce and analyze histological slides and is required for students in the Department of Cell Biology and Molecular Medicine.  It will offer students practical knowledge and experience for methods that may be used for research in many fields, including cardiovascular biology.  Class format will include presentations and demonstrations followed by student practice.  The course will formally meet for 13 sessions (once per week for 1 hour each session) and will require additional student scheduling outside of these sessions. 

CBMM5150 Teratology. 2 cr. Spring

An advanced course designed to analyze the mechanisms involved with all areas of abnormal embryonic development in humans and animals. Conferences, demonstrations and seminars are given. Prerequisite: CBMM5020.

CBMM5300 Advanced Cell Biology 3 cr. Spring

Advanced Cell Biology is a graduate level course offering state-of-the art lectures on the structure and function of cellular organelles, membranes, nucleus, cytoplasm, and components of the extracellular space. Each lecture will be given by an expert in the respective field and will cover basic information as well as the most recent developments. Spring semester. This course is offered every other year. It alternates with CBMMM 5330 Cell Biology of the Host-Tissue Response to Injury.

CBMM5330 Cell Biology of the Host-Tissue Response to Injury. 3 cr. Spring

An advanced course designed to further understand the hosts responses to injury. This course outlines the biochemical and cellular response to injury using the liver and endothelia as model systems. Lectures will detail the host reactions to injury and inflammation at the cellular and molecular levels. Reading assignments will emphasize critical developments in the field. Prerequisites: CBMM5060, BIOC5010 and permission of the instructor. Spring semester. This course is offered every other year. It alternates with CBMM 5300 Cell Biology.

CBMM5350Q Molecular Medicine of the Heart. 3 cr. Fall

The course will address the mechanisms of heart function and dysfunction in an integrated approach including morphology, physiology, biochemistry, molecular biology, pharmacology and the basics of cardiovascular disease. The course will include invited guest speakers from other medical schools who are prominent clinician-scientists and who practice clinical cardiology and perform basic science research. The following topics will be covered: - Structure of the heart; - Physiology and electrophysiology; Excitation-contraction coupling; Coronary flow and oxygen supply; - Metabolism; Cardiac signaling; Gene and protein response to stress in the normal heart ;Hypertrophic response: the athlete's heart versus the hypertensive heart; Maladaptation to disease: ischemic injury and infarction; End-stage of disease: heart failure; Clinical correlate to ischemia and infarction; Clinical correlate to hypertrophy and heart failure; Course evaluation will be based on written answers to questions related to the different topics.

CBMM591A-D Cell Biology Seminar. 1 cr. Fall and Spring

Topics of current research interest are presented and discussed by invited speakers, faculty, and advanced graduate students. May be repeated for credit (maximum of 4 times).

CBMM593A-C Cell Biology Research.1 cr. Fall and Spring

Supervised student research in one or more areas of current investigation in the Department. Projects selected are not part of the masters or doctoral thesis. May be repeated for credit (maximum of 3 times)

CBMM594A Regional Gross Anatomy-Thorax and Abdominopelvis. 3 cr. Spring

Regionally dissect human cadaver to understand and describe normal human structure through the use of correct anatomical terminology. Learn important functional relationships of the dissected structures. Extrapolate basic anatomical knowledge to understand selected clinical examples.

PHPY5950 Frontiers in Cardiovascular Research. 1 cr. Spring

This course is taught jointly by the departments of Cell Biology & Molecular Medicine and Pharmacology and Physiology. This course is directed at more advanced graduate students interested in the latest developments in cardiovascular research. One-hour seminar presentations covering recent publications having a major impact on cardiovascular research will be presented by faculty actively engaged in cardiovascular research at UMDNJ. In addition, guest speakers involved in seminal research may be invited, when possible, to participate in this course. Required readings pertaining to course topics will be assigned prior to each class. Evaluation will be based on attendance, participation in discussions and submission of a short paper.

DIVISIONAL COURSES

GSND 5001 Ethics in Science, Research, and Scholarship. 1 cr. Spring

Multidisciplinary course required for all doctoral candidates. This course is designed to provide students with a practical basis for coping with ethical issues which may arise in their careers as students and investigators. This includes developing awareness of standards and policies (including guidelines and regulations) concerning scientific conduct at both the federal and university levels.

GSND 5200 Molecular & Cellular Biology (Core Course Part I). 5 cr. Fall

GSND 520 Molecular & Cellular Biology (Core Course Part II). 3 cr. Spring

The Core Curriculum is designed as a comprehensive interdisciplinary course for all first year graduate students in the Graduate School of Biomedical Sciences. The goal of the Core Curriculum is to provide a broad foundation in biomedical sciences and serve as a framework for advanced study in more specialized areas. The class will meet for three two-hour sessions each week. The course consists of eight modules, four of which will be covered in the fall semester for five credits, and the remaining four will be offered in the spring semester for three credits. Modules include molecular structure and metabolism, information transfer, cellular structure and function, cellular physiology, immunology, signal transduction, cell cycle regulation, and higher levels of organization in the nervous system. Examinations will be in an essay format, with at least one exam for each module. Final grades for each semester will be determined from the average of the module exams. The required textbook for the course is Molecular Biology of the Cell, 4 th edition, by Alberts, Johnson, Lewis, Raff, Roberts, and Walter, 2002, Garland Science.

*GSND N500A Fundamentals of Biomedical Sciences I. Biochemistry and Molecular Biology. 3 cr Fall [masters students only]

This course is Part I of the evening fundamentals course that is given to Masters Students. This course covers basic biochemistry and molecular biology. The nature of the major macomolecules will be discussed and their role in the regulation of carbohydrate, lipid and amino acid metabolism will be illustrated. The synthesis of proteins and nucleic acids will be reviewed and the experimental techniques used in molecular biology will be considered. A review of the regulation of gene expression and intermediary metabolism will serve as an introduction to a more extensive consideration of the material to be discussed in the cell biology course in the following semester. Throughout the course an effort will be made to indicate the relevance of biochemistry to clinical medicine.

*GSND N500B Fundamentals of Biomedical Sciences II. Cellular Biology. 3 cr. Spring masters students only]

This course is Part II of the evening fundamentals course that is given to Masters Students. Students are introduced to cellular structure and function. Topics include techniques for cell study, cell compartments, specialized cell types, basic tissue biology, the cell cycle, communication between cells and signal transduction.

*GSND N500C Fundamentals of Biomedical Sciences III. Systems Biology. 3 cr. Fall [masters students only]

This course is Part III of the evening fundamentals course that is given to Masters Students. It is given in three modules: Neuroscience, Endocrinology and Immunology. Each module attempts to show how the molecular, biochemical and cellular machinery of a system (covered in parts I and II of the evening Core courses) combine to produce a functional component of the organism. The modules combine didactic presentations with readings and discussions of original literature in the area and how all of this information is being used to understand and treat medical problems and disease.

GSND N5310 Clinical Trials Overview: Methodology and Practice. 3cr. Spring

This course is designed to teach researchers at all levels (investigator, study coordinator, study monitor, study staff) the fundamentals of a good clinical trial in the evaluation of a new drug or device, be it sponsored by an industry, federal or philanthropic organization. Whether the ultimate purpose is to create a clinical protocol, or to carry out or monitor a protocol, understanding the options and reasons for a clinical trial design impacts the daily conduct and success of the trial. Discussion starts with the evaluation process leading up to human volunteer trials, through elements in designing a trial, writing the scientific protocol, considering regulatory issues and human subjects protection, through elements in protocol development/implementation, sample size determination and analytic strategy.

GSND 5300 Independent Study in Biomedical Sciences. 1-4 cr. Fall and Spring

This course provides a mechanism for students to gain academic credit for participation in graduate level courses at other academic or non-academic institutions, or to take an individually tailored course of study under the direction of a GSBS faculty member. The course should not be equivalent to a course already offered by the GSBS. Special permission of the Senior Associate Dean is required to take this course.

A written proposal justifying the course should be submitted to the relevant graduate program committee. The graduate program committee will also specify the number of credit hours to be assigned (maximum of 4 credits). All aspects of granting course credits are subject to final approval by the Senior Associate Dean. The student shall receive the grade, if any, assigned by a participating external institution for the course. If no grade is assigned by the participating institution, the student will receive a grade of Satisfactory/Unsatisfactory, assigned by the student's graduate program committee. All courses of study under the direction of a GSBS faculty member shall be assigned a grade of Satisfactory/Unsatisfactory, and will require approval of the relevant program committee.

GSND 5400 Investigation Radiology Techniques in Human. 2 cr. Spring

Functional MRI and Position Emission Tomography (PET) are used to study brain function in humans. The course uses lectures sessions to familiarize students with the procedures and software so that they may be able to use them is their research.

GSND 591 A-H MD/Ph.D. Seminar/Journal Club. 1 cr. each semester Fall and Spring

Students taking this course must be enrolled in the dual MD/Ph.D. program. This course provides the opportunity for students to interact with colleagues on scientific issues in an active learning environment; develop presentation and communication skills; get exposure to a variety of scientific areas and techniques, get feedback on ideas and projects, and to discuss issues related to the MD/Ph.D. experience. Grading is Pass/Fail and evaluation will be based on class participation.

MSBS 5000 Masters Thesis Research. 5 cr. Fall and Spring

Students choose a research advisor from the GSBS faculty and engage in laboratory research leading to a dissertation describing the work. Students must form a 3 person advisory committee, have the committee approve the research proposal (3-5 pages) and once the research is completed, approve the written dissertation. A formal oral defense is not required. The usual time to complete the work is from 3 6 months.

MSBS 5010-Seminar in Homeland Security and Domestic Preparedness. 2cr. Spring

The course will review the relevant literature including current events to discuss emerging trends, themes, issues, and other topics related to homeland security and domestic preparedness. Possible discussions could include technology transfer from military applications, funding for end-users, public health infrastructure, emergency preparedness, and the role of universities in homeland defense and domestic preparedness. In addition, the seminar will help to lay a foundation for a new generation of citizen-scientists; special attention will be paid to development of well-round ideas related to homeland security and domestic preparedness.

MSBS 5100 Current Molecular Techniques. 3 cr. Spring

The goal of this course is to provide graduate students with an understanding of the concepts and practice of contemporary molecular techniques. The emphasis of the course will be on exposure to and experience with methodologies. Therefore, a major aspect will be actual hands-on experience in basic research laboratories. There are three organizational modules and associated with each module are 7-10 techniques. Students will be divided into small groups (3-4) and will be assigned a technique. Senior graduate students, Post docs, or P.I.s will offer direct training in laboratories currently using the technique, over the span of 1-2 days. Each small group will then make a presentation to the entire class. These presentations will include (1) a detailed protocol, (2) any data derived from the technique studied with experimental context and (3) a discussion of the strengths and weaknesses of the method.

MSBS 5120 Pharmaceutical Internship. 2 3 cr. Fall and Spring

Students enter the research laboratory of a scientist at one of the Pharmaceutical Companies and work on a project agreed upon by the Instructor and the Program Director. The instructor must have an adjunct appointment with GSBS. The number of credits is determined by the hours spent in the laboratory. Grades are assigned on the basis of a written report submitted to the Instructor and the Program Director and on a research seminar presented by the student describing the work.

MSBS 5130 Stem Cell Biology and Applications in Molecular Medicine. 3 cr. Fall

This course provides students with an understanding of basic stem cell biology and how stem cells may be used in clinical medicine.

MSBS 520 Advanced Stem Cell Seminar. 2 cr. Fall

This course entails reading/discussion on current topics pertaining to stem cell repair for tissue/organ disorders. In addition, topics will include areas of bone marrow stem cells as sources of the emerging immune system and the relevance to pharmaceutical compounds. Course to be given in conjunction or following MSBS 5130 (Stem Cell Biology and Applications in Molecular Medicine)

MSBS 5140 Biological Terrorism and Weapons of Mass Destruction. 3 cr. Fall

The goals of this course are to gain a knowledge of the history of agents of biological warfare, including political considerations, development, and use, and to relate this information to the potential for tactical/terrorist deployment; to gain a knowledge of the biology of agents of biological warfare and terrorism, including microbiology, genetics, immunology, identification, diagnosis, and disease; to gain an appreciation for the overall effects of biological weapons use, including detection and epidemiology, emergency response and management, and psychological impact; to understanding the difficulties in control and non-proliferation, including difficulties in fashioning a verification protocol to the current Biological Weapons Convention.

MSBS N5150 Embryology and Teratology. 3 cr. Spring.

This course is designed to discuss normal development, and to analyze the mechanism involved with all areas of abnormal embryonic development in humans and animals. Lectures, conferences, demonstrations and seminars are given.

MSBS N517Q Introduction to Select Agent Biology. 3 cr. Spring

The designed to give students a working knowledge of the various biological aspects of select agents and research. The course topics include: select agents, bio-safety and regulations; host response to select agents; bacterial select agents and pathogenesis and virulence; viral select agents; and toxins' mechanisms of action. This course complements the other biodefense policy courses in the BioDefense Certificate program.

MSBS 591 Seminar in Biomedical Sciences. 1 cr. Fall.

This seminar course is required of all MSBS students and replaces seminars taken formally in individual departments. Eight to twelve researchers from different departments in the GSBS present their research (1 hour) and then engage in discussion with the students. Students are given papers to read one week prior to faculty presentations and students are assigned to lead discussion each week. Student evaluations are based on classroom participation and a paper submitted at the end of the semester critically analyzing one of the presentations and proposing future experiments in the field in the form of one specific aim.

MSBS 593 Research in Biomedical Sciences. 2 cr. Fall.

This lab rotation allows Masters students to do laboratory research with a mentor in the NJ Medical School or NJ Dental School. Students are evaluated by submitting a paper summarizing their research to be evaluated by the course instructor and by a written evaluation from their mentor.

BIOINFORMATICS

GINF 5001 Fundamentals of Bioinformatics. 3 cr. Fall and Spring

Introduction to the field and its tool sets: the algorithms of informatics, sequence analysis, molecular modeling, integrated informatics environments, and the UNIX environment. TEXT: Instant Notes in Bioinformatics, D.R. Westhead, J.H. Parish, R.M. Twyman. Bios Scientific Pub Ltd, 2002. Evaluation to be based on assignments, participation, and culminating bioinformatics practicum.

GINF 5002 Structural Bioinformatics II . 3 cr. Fall.

Homology modeling, advanced alignment and structural searching, docking, and molecular dynamics applied to drug design and the study of biophysical problems (e.g. impact of protein folding on disease states) ranging from small proteins to the study of larger complexes. (e.g. ribosomes). Prerequisite: Structural Bioinformatics I or Permission of Instructor.

GINF 5003 Structural Bioinformatics I. 3 cr. Spring.

Introduction to protein structure and modeling. Manipulation, viewing, and analysis of biopolymers. Alternative approaches to drug design and analysis of molecular interactions important for development of novel small molecule therapeutics from lead compounds (isolation of the pharmacophore). Prerequisites: Fundamentals of Bioinformatics.

GINF 5004 Bioinformatics Platforms and Application Development . 3 cr. Fall.

Bioinformatics programming (in Perl) and selected application scripts as used to automate processes. Operating systems, computing strategies and hardware platforms. Quizzes derived from questions created by instructors. Semester project in answer to one of a set of assigned research problems in the form of an application or bioinformatics environment. Sample text: Beginning Perl for Bioinformatics, James D. Tisdal, O'Reilly & Associates. Prerequisites: Fundamentals of Bioinformatics.

GINF 5020 Biological Database Systems and Computational Genomics. 3 cr. Spring.

Public and proprietary sequence databases, the applications that address them, their management and integration. Sequence analysis and manipulation; array analyses, proteomics and genomics. Prerequisites: Fundamentals of Bioinformatics

GINF 5030 Special Topics in Bioinformatics. 1 3 cr. Spring.

Independent study and project development in Bioinformatics growing from subject matter introduced in the GSBS Bioinformatics Curriculum: sequence analysis, structural bioinformatics, genomics, and/or application development. Prerequisite: Two courses in Bioinformatics and Permission of Instructor. TEXT: Individually determined, as appropriate. Evaluation based on periodic assignments and major projects.

NEUROSCIENCE

NEUR5000 Thesis Research. 5 or 10 cr. (5 credits for part time students and 10 credits for full time students)

Taken after completion of credit requirements.

NEUR5010 Neurosciences I. 4 cr. Spring

This course consists of basic medical neurophysiology and neuroanatomy, coupled with clinical correlations presented as part of the program for first year medical students. This course is open to all graduate students. Apr-June .

NEUR5030 Neural Substrates of Aggressive Behavior. 1 cr. Fall

This course examines the anatomical, physiological and pharmacological substrates of aggressive behavior as understood from the animal and human literature. Emphasis will be given to the mechanisms that regulate the expression of aggressive reactions and how they may apply to the organization of aggressive behavior in humans.

NEUR N5031 Neural Substrates of Aggressive Behavior. 3 cr. Fall

This course will cover the following topics: the nature of aggression, definitions of aggression and critique; history of the neurology of aggression and rage; neuroanatomy of aggression and rage; physiological processes hypothalamus and brainstem; limbic system anatomy and functions; neurochemistry of aggression and rage; hormones and aggression; genetics and aggression; human aggression; prospectus for future research on the neurobiology of aggression and rage. Evaluation will be based on a final written examination, experimental design of experiments and paper presentations.

NEUR5040 Neurobiology Disease. 3 cr. Spring

This course will focus in the molecular, cellular and behavioral mechanisms underlying neurological and psychiatric disorders including epilepsy, Multiple Sclerosis, Parkinson's and Alzhelmer's diseases, Depression, Schizophrenia, Addiction, Autism, CNS infections, brain and spinal cord injury and stroke. Lectures will include an overview of neural systems implicated in the diseases, the major issues that are being addressed in basic research in order to elucidate the molecular and cellular mechanisms underlying neural dysfunction and the approaches used to treat disease symptoms.

NEUR5080 Brain-Hormone Interactions. 2 cr. Fall

This course presents the central nervous system structures and pathways involved in the regulation of hormone systems and the effects of hormones on the functioning of the nervous system.

NEUR5110 Foundations of Neuroscience. 3 cr. Fall

This course is the fundamental required course for all graduate students in the neuroscience graduate program. The fall semester covers molecular and cellular neuroscience including neurophysiology and neuropharmacology. This course is team taught using faculty from both UMDNJ and Rutgers University whose expertise is appropriate for the subject.

NEUR 501B Foundations in Neuroscience II. 3 cr Spring

This course covers all the neural systems (e.g.. sensory, motor, and limbic systems) and topics related to cognition and behavior including learning and memory, aggression, motivation, and language. This course is team taught using faculty from both UMDNJ and Rutgers University whose expertise is appropriate for the subject.

NEUR5140 Selected Topics in Neuroimmunology. 1 cr. Spring

This course focuses on the interaction of the vertebrate immune system and the central nervous system. Subject areas to be covered include innervation of lymphoid organs, interactions of neurotransmitters with cells of the immune system, neuroendocrine pathways, expression and function of proteins, hormones and receptors shared by the immune and nervous system as well as the relationship of the neuroimmune axis to disease states. Prerequisite: Immunology or permission of the instructor.

NEUR5150 Developmental Neurobiology. 2 cr. Spring

This course provides an overview of the development of the nervous system from the fertilized egg to the beginning of cognition. Development is discussed in terms of the latest cellular and molecular research on the mechanisms involved in the formation of the complex circuitry of the adult brain and spinal cord. The course assumes basic knowledge of cell biology and neuroscience. Classes consist of lectures, discussions based on study questions, and student presentations based on current journal articles.

NEUR5240 Demyelinating Diseases. 1 cr. Spring

This advanced course is designed to analyze the mechanisms involved in the pathogenesis of demyelination in diseases of the central and peripheral nervous systems. The course will include lectures, conferences and student seminars. Prerequisistes include Neurosciences I (NEUR5010) or Foundations of Neuroscience (NEUR5110 & 501b).

NEUR5940 Methods in Neurosciences. 1 cr. Fall.

A survey course encompassing all the active research laboratories in the graduate neuroscience program. Each session is conducted by a faculty member who explains the research objectives and research methodology of their group.

NEUR 0596 Professional Skills. 2 cr. Spring

There is a set of skills that scientist must possess that are not typically taught as part of graduate program curriculum, yet these skills are fundamental of the success of future graduates. These skills include the ability to write, present, and critique scientific material; to efficiently manage time, manage information and personnel to secure employment, to master the process of writing and submitting grants, and to know how to conduct oneself at meetings and seminars.

NEUR5950 Clinical Neurosciences 2 cr. Spring

This course is designed to give an introduction to the practice of neurology for graduate students in neurosciences. Specifically, the student will be introduced to current neurological diagnostic and therapeutic techniques: where in the nervous system is the lesion, what type of lesion is it, and how can I best treat it? Emphasis will be placed on determining lesion localization and disease type from the history and neurological examination. A series of teaching videotapes will be used to familiarize students with approaches to patients with problems with higher cognitive functioning, cranial nerves, strength, sensation, and reflexes. Common diagnostic techniques such as electroencephalography, electromyography, neuropsychological testing, radiological imaging of the brain with computerized tomography and magnetic resonance, cerebrospinal fluid analysis, evoked response testing will be introduced. Common neurological diseases such as epilepsy, dementia, cerebrovascular disease, Parkinsonism, neuropathies, compression syndromes, and malignancies will be discussed. Multiple sclerosis will be highlighted because of its ability to teach about lesion localization and pattern of neurological involvement. The overlap of psychiatric disease with neurology and its artificial separation from neuroscience will be discussed. The student will learn how the neurologist diagnoses, treats, and manages patients with neurological problems and will thus learn the limits of current knowledge of normal and abnormal neurological function. It is anticipated that this course will aid in structuring of research foci, and the utility of neuroscience research in improving the neurological health of mankind. Prerequisite: NEUR 5110 & 501b.

NEUR591n Seminar in Neurosciences. 1 cr. Fall and Spring

Reading from and discussion with the seminar speakers. Students attend a pre-seminar to discuss the topic to be covered by the speaker. The seminar itself is followed by a post-seminar session with the speaker to discuss his/her topic in depth.

NEUR593n Research in Neurosciences. 1-6 cr. Fall and Spring

Research rotations in the laboratories of the graduate neuroscience faculty at both UMD and Rutgers acquaint students with the types of research available for thesis projects, teach research techniques, and provide opportunities to obtain preliminary research data for applications for research predoctoral grants. Most rotations are 3 crs. Students are asked to write, with the faculty, a brief note on the project that will be undertaken and the techniques that will be used. At the end of the rotation, a paper is submitted describing the results of the work. Students can take several rotations.

NEUR R509 Statistics for Neuroscience 3 cr. Fall

The statistics course is offered through the graduate neuroscience program at Rutgers specifically for neuroscientists. The basics of probability tests and experimental design are offered. The content is meant to prepare students for analysis of a wide range of data from molecular biological results to behavioral testing.

Additional courses in neuroscience offered at Rutgers University Newark ; see

www.ins-rutgers-umdnj.rutgers.edu/html/course_description.html

Neuroanatomy; Neuropharmacology; Statistics II; Learning and Memory; Cerebral Cortex; Limbic System Critical Thinking

MICROBIOLOGY AND MOLECULAR GENETICS

MICR5040 Advanced Microbial Genetics. 6 credits. Spring semester.

This course is required for all graduate students in the Department of Microbiology and Molecular Genetics; other graduate students may elect to take the course, with permission of the coordinator. The goal of this genetics course is to introduce students to the application of a wide range of genetic techniques to the basic processes that characterize phage, bacteria, yeast, eukaryotic viruses and higher eukaryotes. Topics include: Nucleic acid (structure, synthesis, mutation, and recombination); Gene regulation (transcriptional, translational, and post-translational); Regulation of processes (cell division, phage and viral growth, development); Research tools (proteomics, application of chips to genetic problems, gene expression, vectors), and Evolution (genomics, selection, and prokaryotic population structure). The readings portion of the course is designed to provide students the opportunity for detailed reading of original research papers related to lecture topics. Students will be guided in their analysis of these papers, and will present both oral and written reports which are intended to focus the students' attention on experimental controls, significance of results, details of methods, experimental power and a wide range of experimental approaches to problem solving and to increase their skills in scientific communication .

MICR5620 21 st Century Pathogens. 3 credits. Fall Semester.

This course provides an in-depth examination of selected viral, bacterial, fungal and parasitic infections agents. The course is structured with two parts; formal lecture and class discussion of primary literature. Topics covered include: tuberculosis, listeria, anthrax, DNA viruses and retroviruses, HIV pathogenesis, Cryptococcus infections, antifungal drug mechanisms, trypanosomiasis and malaria.

MICR5630 Teaching Skills for Medical Microbiology Laboratory. 3 credits. Spring Semester.

Students learn microbiology lab skills for their own edification and for teaching 2 nd year medical students after completion of phase 1 of this teaching program. Students perform each lab at their own pace. They also receive 6 30-40 minute tutorials from departmental faculty on each lab topic, including bacteriology, parasitology, and fungal infections. Students are graded on presentation and on a final examination.

MICR5631 Applications of Teaching Skills in Medical Microbiology Laboratory. 3 credits. Fall Semester

Students will practice and prepare presentations which they will give to medical students in labs 2 times per week. Grading of students is by course coordinator and participating faculty and is based on the student's preparation of material and delivery of material to medical students.

MICR591(A,B,C,D) Microbiology Seminar. 1 cr.

A weekly series of lectures by distinguished invited speakers designed to acquaint students with the most recent developments covering a broad area of molecular biology. Sept-June

MICR593 (A,B,C,D) Research in Microbiology. 1-10 cr.

Original laboratory research conducted during the first two years of graduate studies. Sept-Aug

MICR5000 Thesis Research. 5 or 10 cr. (5 credits for part time students and 10 credits for full time students)

Taken after completion of credit requirements. Fall and Spring.

MICR5210 Transcription and Processing of Procaryotic and Eucaryotic RNAs. 1 cr.

The course covers the transcription apparatus, the structure of messenger RNA, complexity of mRNA populations, heterogenous nuclear RNA, interrupted genes and RNA splicing, polyadenylation and posttranscriptional control. To be arranged.

MICR5230 Topics in Tumor Virology. 1 cr.

The course will cover developments in papovaviruses (SV40 and Polyoma), adenovirus, and retroviruses. To be arranged.

MICR5231 Molecular Virology. 3 cr. Spring

This goal of this course is to introduce students to the basic principles of virus-host cell interactions and the molecular basis of pathogenesis. All important human virus will be discussed, including papilloma, herpes, smallpox, polio, measles, West Niles , HIV, influenza, SARS and hepatitis viruses. Lectures cover viral structures, viral strategies of invasion, transcription, replication, and dissemination, viral offense and hose defense, prevention and control of viral diseases, and approaches for studying viruses.

MICR N5233 Pathogenic Microbiology. 3 cr. Spring

This course is directed at Master-level students. It will focus on microbes of clinical interest by providing in-depth discussions of key microbes and their virulence factors, susceptibility mechanisms, and future challenges, rather than be a broad survey of all medically relevant microbes. It will also discuss basic principles as they relate to or enhance our understandings of the molecular basis of infection. Experimentation methods and interpretation will be emphasized. The course will be given as a weekly series of 3 hour evening lectures during the spring semester. Course content will include: Basic molecular microbiology; mechanisms of pathogenesis and drug resistance; tools for diagnosis/experimentation; in-depth treatment of select bacteria, fungi, and parasites, as well as a brief treatment of viruses (treated in detail by Molecular Virology). The required textbook will be Lippincott's illustrated Reviews, Microbiology (2001), with the suggested textbook Bacterial Pathogenesis: A molecular approach, 2 nd Ed. (2002). Evaluation will be by 3 in-class exams (short answer, diagram, paragraph-no multiple choice).

MICR5250 Yeast Genetics. 1 cr.

Emphasis will be on the use of yeast as a model system for the study of problems in eucaryotic molecular genetics. The topics include: Isolation of mutants and mapping strategies, molecular biology of the regulation of gene expression, and molecular genetics of chromosome structure. To be arranged.

MICR5260 Developmental Biology of Microorganisms. 1 cr.

The development programs of several microorganisms will be closely examined with regard to cell biology, biochemistry, changes in nucleic acid metabolism and cellcell interactions. Both procaryotic and eucaryotic microbes will be discussed. To be arranged.

MICR5270 Genetic Code. 1 cr.

The course will cover the experimental basis for deciphering the genetic code, properties of transfer RNA, fidelity of translation of the code, alternate hypotheses for codon reading, codon usage, and variation in the code. To be arranged.

MICR5340 Protein Traffic. 1 cr.

A seminar course covering the current literature on the subject of the movement of proteins within and without cells. Subjects include bacterial and yeast protein secretion, import of proteins into subcellular organelles including nucleus, vacuole and mitochondria, immunoglobulins, mammalian virus formation, signal sequences. To be arranged.

MICR5350 The Enzymology of DNA Replication. 1 cr.

This course focuses on the biochemical and genetic properties of the proteins involved in the replication of DNA in both procaryotes and eucaryotes. To be arranged.

MICR5370 Topics in Eukaryotic Molecular Genetics. 1 cr.

Lectures, student presentations and discussions focussing on a topic of current interest in the area of eukaryotic molecular genetics. Specific course topic and outline available prior to registration in the semester given. To be arranged.

MICR5380 Scientific Communication. 1 cr.

This course will concentrate on the practical application of critical analysis to scientific communication. The course will introduce the student to principles of analysis within the paradigm of the scientific method. The approach will include the critical analysis of writing in the current literature with respect to the various structures of scientific writing and their goals. Exercises designed to develop the ability of the student to discuss experimental data particularly in a critical summary form will be emphasized. The class also will address principles of oral communication of scientific data, concentrating on differences and similarities to written forms. To be arranged.

MICR5410 Molecular Biology of HIV. 1 cr.

This course covers the molecular aspects of the life cycle of human immunodeficiency virus. Topics discussed include HIV gene organization, gene expression, transactivators, proteolytic processing, frameshifting, replication, posttranscriptional regulation, cellular interactions, antiviral strategies, and animal model systems. To be arranged.

MICR5420 Accuracy in Molecular Processes. 1 cr.

The accurate processing of genetic information is fundamental to the growth, development, and function of living cells. This course will review the study of accuracy in molecular biology. Specific topics include defining the accuracy problem, mechanisms responsible for maintaining accuracy in molecular processes, the cost of accuracy to the cell, and the relevancy of accuracy to the integrity of genetic information flow, as may occur during aging or cancer. To be arranged.

MICR5430 Genetics and Early Development. 3 cr. Fall Semester.

This course covers basic general and molecular human genetics, the molecular basis of human diseases, and an introduction to the biochemical and molecular basis of early development. Nov.-Dec

MICR5450 Topics in Molecular Genetics of Pathogenesis. 1 cr .

This course will combine genetic and molecular approaches to understanding a current problem in bacterial and parasite pathogenesis. The course will be structured around the reading and analysis of current, significant publications, but classical literature will also be analyzed. To be arranged.

MICR5460 Topics in Transcriptional Regulation of Gene Expression. 1 cr.

This course will provide indepth coverage of RNA transcription with a focus on proteinDNA and proteinprotein interactions. Current literature will be read and discussed. Topics may include the effects of transcriptional control on differential gene expression, development, DNA replication, and DNA repair. To be arranged.

MICR5470 Topics in Regulation of Cell Proliferation. 1 cr.

This course will focus on genetic and molecular approaches to current problems in mammalian cell proliferation. The course will be structured around current publications. A series of introductory lectures will be followed by student presentations of selected papers in a seminar format. Topics will include, but not be limited to, carcinogenesis and cellular aging (senescence). To be arranged.

MICR5480 Topics in DNA Metabolism. 1 cr.

This course will focus on advances in the field of DNA metabolism, including DNA replication, recombination, repair, and other relevant processes in both prokaryotic and eukaryotic systems. Emphasis will be placed on the importance of DNAprotein and proteinprotein interactions and the relationships between these processes. Instruction in the fundamentals of DNA metabolism will be presented, and current issues in the field will be discussed by reviewing significant articles in the literature. To be arranged.

MICR5500 Topics in Developmental Genetics. 1 cr.

One of the most conspicuous features of animal morphology is asymmetry along one or more axes. Anterioposterior (AP) and dorsoventral (DV) asymmetries have been studied in detail. However, vertebrates and some invertebrates are also morphologically asymmetric along the leftright axis. This minicourse will combine genetics and development to understand the molecular basis for asymmetry and will be limited to a discussion of information provided by model systems with a special focus on the mouse model. The course will be structured around current, significant publications. To be arranged.

MOLECULAR PATHOLOGY AND IMMUNOLOGY

PATH5000 Thesis Research. 5 or 10 cr. (5 credits for part time students and 10 credits for full time students) Fall and Spring.

Taken after completion of credit requirements.

PATH5010 General Pathology. 3 cr. Fall

A combined lecture and laboratory course that illustrates the general principles of Pathology. Topics include cellular reactions to injury; inflammatory reactions; thrombosis, embolism and infarction; metabolic, genetic and nutritional deficiency diseases; pathology of neoplastic disease; immunopathology. Lectures, laboratory sessions in histopathology and attendance at gross specimen demonstrations are all utilized for instruction. Fall Semester. (August October)

PATH5020 Special Pathology. 4 cr. Fall

A systematic examination of the various organ systems of the human body. The course consists of lectures, laboratory exercises and conferences. Prerequisite: PATH5010. October - December

PATH5070 Laboratory Animal Science 3 cr. Spring

This is an introductory course dealing with the care and use of animals in biomedical research. The course covers history of animal research, ethics and animal rights, Federal Regulations, the IACUC, and search for alternatives, animal models and research use. Also discussed are the husbandry, care and use of and common diseases and procedures in rats, mice and rabbits. The laboratory sessions provide the student with hands-on experience in handling the above species and an opportunity to practice the procedures as described. This 3-credit course is given as 11 one-hour didactic sessions each followed by a two-hour laboratory session. A midterm and a final exam are included.

PATH5080 Immunoglobulins in Host Defense Disease. 1cr. Spring

This course focuses on the roles of immunoglobulins in host defense, and as tools for diagnostics, therapeutics, and research. Each course meeting consists of a faculty lecture and a student presentation of a journal article.

PATH5100 Cellular Pathology. 3 cr. Fall

This lecture course provides the student with a fundamental indepth understanding of current concepts of cell biology and of basic types of pathological processes at the cellular level. Microscopic, submicroscopic, and molecular models of both normal and diseased cells will be critically examined and discussed, with special attention to chromatin structure, and DNA damage and repair, leading to the students' understanding of expanded investigative concepts and the formulation of new concepts. Sept-Dec

PATH512A Advanced Topics in Immunology. 2 cr. Spring

An indepth analysis of a selected topic of contemporary immunology each time the course is offered. The course format includes lectures that provide an overview of the topics, interspersed with presentations and discussions by students and faculty of journal articles, which illustrate the relevant immunologic mechanisms and/or theories involved. Since the topics change, students may enroll for credit in successive years. Recent topics have included: viral immunology, transplantation, autoimmunity, tumor immunology and cytokines. Prerequisite: PATH5150 or equivalent introductory immunology course. Feb-May

PATH5130 DNA Damage and Repair. 1 cr. Spring

This course critically examines the types of damage that occur in DNA due to both chemical and physical agents. The mutagenic and carcinogenic potential of many of these agents will be discussed. The basic mechanisms by which damage to DNA induced by these agents is repaired, such as the various types of excision repair and postreplication repair, will be examined in turn. Several diseases in which these mechanisms are defective, such as xeroderma pigmentosum, ataxia telangiectasia, Fanconis anemia and Blooms syndrome, will be examined and used as models to elucidate the effects of defects in these DNA repair systems. This course will consist mainly of lectures accompanied by student presentations. Each student will give one presentation on a specific topic. Mar-May

PATH5160 Tumor Cell Biology. 1 cr. Spring

An overview of cellular and molecular biology of the human cancer cell, stressing the recently acquired information of the genome and its normal and aberrant expression, and the cell culture approach to the study of human material, especially the leukemic cell. Topics will include the recognition of the cancer cells, its characteristics, cytogenetics, oncogenes, growth factors and receptors, control of the cell proliferative cycle, stem cells and differentiation. Carcinogenesis and tumor progression will be considered from the point of view of the interaction of a cell with an ongoing genetic program reacting to a changing environment. January - March

PATH5170 Basic Mathematics and Computer Science with Applications in the Biological Sciences and Statistics. 2 cr. Fall

This course will focus on fundamental aspects of mathematical relationships that repeatedly arise in the biological sciences. Its focus will be practical, rather than theoretical, with emphasis on solving specific problems. Functions based on exponential relationships, such as cell proliferation, cell cycle distribution, radionucleotide decay, diffusion, Newton 's law of cooling, and the BeerBougetLambert law will be emphasized. Applications of the binomial, Poisson, and Ganssian distributions and selected areas in statistics will be discussed. Use of computers to facilitate problem solving will be introduced. Students will be evaluated on the basis of homework problems, class exercises, and a final examination. Sept-Dec

PATH5200 Developing Skills in Scientific Communication. 2 cr. Spring

This course is designed primarily for first and second year students. The main objectives are to provide students with an opportunity to develop skills in the interpretation, evaluation and communication of scientific information and to reinforce, enhance and supplement material and concepts in contemporary aspects of the biomedical sciences. Suitable and appropriate articles for presentation will be selected by the students working together with a course director. During the semester the students will evolve a research project which will be used as the basis for the presentation of an abbreviated NIH style research proposal. Students will prepare the proposal throughout the semester. Jan-May

PATH N5209 The Business of Science: Drug Development Discovery to Market. 3 cr. Fall

The goals of this course are to survey the basic concepts and strategies for drug discovery and development, with an emphasis on practical applications rather than theory; provide in-depth consideration of the key phases of pre-clinical drug discovery; examine the impact of rapidly changing disruptive technologies on the processes of drug discovery; study the basic design and conduct of phase 1-4 clinical trials; provide a forum for discussion of practical considerations of careers in drug discovery/development; and provide and opportunity for practical application of concepts.

PATH5210 Molecular and Cellular Immunology. 3 cr. Spring

This course provides an in-depth examination of contemporary immunology for students without a previous graduate level immunology course. Basic concepts of cellular and humoral immunity are covered, including cellular interactions, the genetics of immunoglobulin and T cell receptors, cytokine networks, antigen processing and antigen/antibody interactions. These basic concepts are then integrated with current in vivo and in vitro experimental approaches to investigate clinically relevant aspects of the immune system, such as tumor immunology, autoimmunity, immunopathology, transplantation, immunodeficiency, and hypersensitivity. Jan-May

PATH N5211 Immunology. 3 cr. Spring

The goals of this course are to provide in-depth information on all aspects of modern immunology and bring the students up to date with the latest developments in the field of immunology. This course provides the basic concepts of both cellular and molecular immunology. Subjects covered include innate and acquired immune responses. The beginning of the course concentrates on the cells involved in the immune response, the mechanisms respolnsible for the generation of diversity in the immune response and aspects of the maturation of the immune response. Topics covered extend to cellular interactions, complement system, cytokine networks, antigen processing, immune completes, and signal transduction. The last third of the course concentrates on alterations in immunity that occur following infection, the interactions between neural and immune systems, autoimmunity, hypersensitivity, cancer, transplantation, and immunodeficiency. This course is taught by faculty whose course interests and expertise involve immunology. Evaluation will be based on a mid term, a final, and a student paper evaluation of literature reports.

PATH5220 Fundamentals of Immunology. 2 cr. Fall

Introductory level course in immunology, covering the basic concepts of the cells and humoral products of the immune system, the genetics of immunoglobulin production, and antigen - antibody reactions. Using an approach that correlates these basic concepts with clinical manifestations of disease, the immunopathologic mechanisms of hypersensitivity, autoimmunity, transplantation, tumor immunology and immunodeficiency are presented. Aug-Nov

PATH5600 Molecular and Immunopathologic Mechanisms of Cancer. 3 cr. Spring

This course offers a comprehensive presentation of cancer as a disease. The introductory lectures include an overview of the etiology of the most common types of cancer; the prevalence of cancer in the U.S.A. ; the economics of cancer; and a brief chronology of the progress that has been made in cancer research. Subsequent lectures consider the morphological, biochemical, and molecular characteristics that distinguish normal cells from cancer cells, and some of the experimental approaches that are used to investigate cancer. In the remainder of the course more detailed information is presented about the genetic abnormalities that contribute to cancer development; mechanisms of mutagenesis and DNA repair; the role of oncogenes, transcription factors, signaling pathways, and apoptosis; and the multi-hit mechanisms of cancer progression. The final component of the course includes topics related to angiogenesis and metastasis; principles of cancer immunology; the phenomenon of multi-drug resistance in cancer cells; and contemporary and future strategies for cancer treatment and prevention. May-June

PATH N5601 Pathobiology and Mechanisms of Cancer. 3 cr. Spring

This course offers a comprehensive presentation of cancer as a disease. The introductory lectures include an overview of the etiology of the most common types of cancer; the prevalence of cancer in the U.S.A. ; the economics of cancer; and a brief chronology of the progress that has been made in cancer research. Subsequent lectures consider the morphological, biochemical, and molecular characteristics that distinguish normal cells from cancer cells, and some of the experimental approaches that are used to investigate cancer. In the remainder of the course more detailed information is presented about the genetic abnormalities that contribute to cancer development; mechanisms of mutagenesis and DNA repair; the role of oncogenes, transcription factors, signaling pathways, and apoptosis; and the multi-hit mechanisms of cancer progression. The final component of the course includes topics related to angiogenesis and metastasis; principles of cancer immunology; the phenomenon of multi-drug resistance in cancer cells; and contemporary and future strategies for cancer treatment and prevention. January May

PATH591A Pathology Seminar. 1 cr. Fall and Spring

A series of presentations in contemporary Experimental Pathology offered on a biweekly basis by visiting scientists or faculty. All Pathology graduate students are expected to attend. Oct-June

PATH592A Pathology Journal Club. 1 cr. Fall and Spring

A biweekly discussion of current literature. Attendance of all Pathology graduate students is required. Oct-June

PATH593A Research in Experimental Pathology. 1-6 cr. Fall and Spring

Non-thesis related research projects in Experimental Pathology, under the supervision of faculty members.

ORAL BIOLOGY COURSE DESCRIPTIONS

DENT 5065Q Dental Physiology. 5 cr. Fall

Dental Physiology is a first year dental school course that is open to a limited number of masters students.  Physiology is the study of function in living organisms. The course consists of seven units: (1) Cell Physiology, (2) Endocrinology, (3) Gastrointestinal Physiology, (4) Cardiovascular Physiology, (5) Renal Physiology, (6) Respiratory Physiology, (7) Neurophysiology. Each unit addresses the general principles of human cell, organ and vital system function. Lectures consist of 50 minute oral presentations with slides. Laboratory or Physiological Application (PA) modules provide experience applying basic physiological principles introduced in lectures and promote critical thinking skills. These exercises help the student integrate physiological concepts across organ systems as well as understand their application to clinical dentistry. To facilitate these goals, guest lecturers will participate in some PA modules. When possible, class time has been assigned for PA preparation. The format of each session will be individualized to fit the needs of the unit. Specific instructions about the class discussion for each exercise will be provided at the beginning of each unit. Students may work independently or in small groups to prepare each assignment.

DENT 7106Q Dental Histology. 5 cr. Fall

Dental Histology is a first year dental school course that is open to a limited number of masters students. The Histology course is a combination of a traditional microscopic anatomy course with additional information from the fields of biochemistry, cell biology, maxillofacial development, immunology, pathology and physiology. The course consists of a series of lectures and slide presentations. Lectures include structure-function relationships based upon information from light and electron microscopy, histochemistry, autoradiography, experimental morphology, cell and molecular biology and other areas. The specific significance of concepts to the understanding of clinical areas of dentistry are emphasized. The correlations with clinical dentistry are mainly in the areas of tissue structure and function. Discussions of the processes of histogenesis and repair are also included.

DENT 5300Q Oral Microbiology. 3 cr. Fall

Oral Microbiology is a second year dental school course that is open to masters students.  This course will provide knowledge of common human oral pathogenic and commensal flora. Using examples of S. mutans, P. gingivalis, A. actinomycetemcomitans, and other significant oral pathogens, students will learn in detail about the life cycle of these organisms inside the mouth, their biochemistry, genetics, and strategies for manipulating
and circumventing the host immune response. The nature and course of the diseases associated with each of these bacteria will be presented in detail, including animal models and vaccination strategies. The course will also cover basic medical microbiology, virology, and mycology.

DENT 5120Q Sensory Physiology of Masticatory  System. 1 cr. Spring
The course “Sensory Systems in the Oral Cavity” is based on the premise that the significance of the oral cavity to the human organism and its complexity require study.  One area of interest that underlies its many functions is its neural substrate, including both sensory and motor components.  It is the neural substrate that supports chewing, speech, swallowing and dysfunction, pain and loss of movement.  This course addresses aspects of proprioception, general sensation, pain, motor activity and central control.  These topics are necessary to gain an understanding of the functional activities of the oral cavity.

DENT 5145Q Introduction to Structural Biology. 1 cr. Fall

The generation of genomic information has exploded in recent years. However, scientists are falling behind in determining the functional implications of such information. The challenge centers on the ability of structural biologists to lead in determining the structures of biomolecules and their complexes to keep pace with the genetic information. A thorough understanding of macromolecular structures is required for the development of structure/function relationships. This course will introduce students to structural biology to gain understanding of macromolecular structure, function, and chemistry of biological macromolecules including proteins, nucleic acids and carbohydrates. Topics in protein folding will also be discussed. Introduction to specific methods for structure elucidation will include X-ray crystallography, nuclear magnetic resonance, and mass spectrometry. Macromolecular structure/function relationships as they relate to disease processes and therapies will also be discussed.  Topics covered include: molecular architecture I (Proteins); molecular architecture II (DNA and carbohydrates); Protein folding; Introduction to structure determination; X-ray crystallography; Mass spectroscopy; Structural Databases; Visualization methods; Comparison of structures; Structure-function relationships; and, Structure design-engineering.

DENT 5220Q Methods in Microscopic Imaging. 2 cr. Fall

PHMS 5025Q    Microbial Biofilms. 1 cr. Spring

This course is aimed at highlighting the biology and significance of surface attached bacteria or biofilms. The course will be divided into one-hour lectures. The lectures will focus on biofilm formation, bacterial mechanisms involved in biofilm development, biofilm structure and the role of biofilms in pathogenesis and disease. The course will also look at mechanisms involved in biofilm resistance, as well as strategies for biofilm control and prevention. In the last section of the course we will discuss scientific methodology used in biofilm research and analysis.  A short-answer written exam will be given at the end of the course for student evaluation. In addition, each student will receive one manuscript to present to the class (15 min presentation).

DENT 5085Q Dental Biochemistry. 4 cr. Spring

Dental Biochemistry is a first year dental school course that is open to a limited number of masters students. The main theme of the Biochemistry course is the correlation of molecular structure and biological function. Accordingly, the course presents the salient facts of Biochemistry from which the general characteristics of structure and function in living systems can be deduced. Emphasis is given to the nature, biosynthesis, and degradation of the major building blocks of cells and tissues; the details, interrelationships, and control mechanisms of the various pathways of intermediary metabolism; the production and utilization of energy and the nature and function of biological catalysis; the nature and expression of genetic information; and the special characteristics of certain organs and tissues. Human biochemistry will be the predominant subject of the course, with emphasis on dental and other clinical problems.

DENT 5310Q Oral Immunology. 3 cr. Spring

Oral Immunology is a first year dental school course that is open to a limited number of masters students. This course is geared to provide students with understanding of basic concepts of immunology, to facilitate a better understanding of immunological basis of oral diseases.  Students will be introduced to the components of the central and peripheral lymphoid organs, and the cells of the immune system.  The concept of innate and adaptive immunity, as it applies to responses to oral microbial pathogens will be covered.  The course content will include immunological processes within the periodontium, crevicular fluid, saliva, and the endodontium. There will be lectures on immunological basis of dental caries and periodontal disease, as well as neoplasia of the oral cavity.  Immunological basis of inflammation and pain will be addressed. In addition, periapical inflammatory responses, and their relationship to oral diseases will be covered.

DENT5000 Thesis Research. 5 cr.

Taken after completion of credit requirements...

DENT5150 Metallic Systems in Dental Biomaterials Sciences. 2 cr. Fall

This course will focus on the general structural configuration of metallic materials as opposed to nonmetallic materials. Emphasis will be on the types of bonds, crystallography of metallic materials and their unique properties. Mechanical behavior and microscopic and microstructural characteristics of metallic materials will be discussed in terms of phase diagrams and phase transition. Typical dental alloy systems will be discussed.

DENT5160 Polymeric Systems in Biomaterials Sciences. 2 cr. Fall

This course will focus on the basic concepts and empirical rules involved in the conversion of a small molecule into a macromolecule in terms of bonding forces, molecular size and molecular weight. Application of polymer sciences to dentistry, general requirements of a polymeric material for use as a denture base, impression material, composite filling material and dentin bonding agent will be discussed.

DENT5170 Introduction to Scanning Electron Microscopy. 2cr.

This is a lecture and laboratory course to familiarize the student with the operation of a scanning electron microscope and the principles of interpretation of the image. The topics covered include the areas of sample preparation, optimization of the microscope operating conditions, factors such as aberrations and astigmatism that limit the probe definition, description of the interactions between the probe and the specimen including elastically and inelasticalloy generated signals, illustration of the working distance, specimen tilting, detector selection and location and other conditions to be used to optimize image, the effect of working distance on the resolution and depth of focus, description of different types of signals (e.g., secondary electrons, backscattered electrons, etc.) and their detectors, the differences between the images using the different signals and other related topics. To be arranged.

DENT5180 Principles of Medical Imaging. 1cr. Spring

Acquisition, manipulation, display, and perception of medical images. Examples of applications drawn from film and digital radiology, teleradiology, computer tomography (CT), magnetic resonance imaging (MRI), and nuclear medicine. Prerequisite: one year of college physics.

DENT591A Research Seminar Series. 1 cr. Fall and Spring

This seminar series brings prominent researchers from around the country to UMDNJ-New Jersey Dental School to present their research.

PHARMACOLOGY AND PHYSIOLOGY

PHPY5000 Thesis Research 5-10 Credits
Research under the direction of a thesis committee. After completion of qualifying examination.

HPY5001 Ethics in Science, Research and Scholarship 1 Credit
Multidisciplinary course taught by all departments.

PHPY5290 Physiologic Principles 5 Credits
Molecular and cellular processes governing organ and system function in mammalian species.

PHPY5020 Principles of Pharmacology 3 Credits
Dose effect relationships, drug antagonism and specificity of drugs for effector systems.

PHPY520A Biophysical Approach to Cellular Neuropharmacology 2 Credits
Topics focus upon post- and presynaptic aspects of chemical transmission.

CBMM5950 Frontiers in Cardiovascular Research 1 Credit
Regulatory mechanisms of cardiovascular biology, microvascular permeability and blood flow.

PHPY5270 Cardiovascular Biology 3 Credits
A contemporary view of cardiovascular pharmacology and physiology.

PHPY5280 Gastrointestinal Physiology 1 Credit
Gastrointestinal physiology and gastroenterology.

PHPYN5225 Principles of Toxicology 3 Credits
Biochemical basis for the action of toxic substances and principles involved in their identification.

PHPYN5060 Topics in Neuroscience 3 Credits
Recent developments in the clinical and basic neuroscience.

PHPY591A Seminar in Pharmacology & Physiology 1 Credit
Presentation of research work with goal of improving presentation skills.

PHPY593A Research in Pharmacology & Physiology 2-3 Credits
Laboratory rotation in any area of pharmacological or physiological investigation.

PHPY5940 Seminars in Neurophysiology/Neuropharmacology 1 Credit
Student presentation of recent advances in Neurophysiology and Neuropharmacology.

(***Not all courses are offered each year or semester)