Meet Tessa L. Bergsbaken, PhD
Tessa L. Bergsbaken, PhD, assistant professor of pathology and laboratory medicine, received her PhD from the University of Washington. Her work examined the activation of inflammatory caspases and pyroptosis, an inflammatory cell death process initiated by these enzymes, in response to bacterial infection. Later studies focused on tissue-resident memory CD8+ T cell populations that develop in the intestinal tissue in response to local infection. She identified the mechanism by which T cells localized to areas of infection within the intestinal tissue and the role of specific inflammatory cytokines in supporting the differentiation and long-term persistence of tissue-resident memory T cells. This work has been published in Nature Immunology and Cell Reports.
Her research interests include understanding T cell differentiation and maintenance in the intestine and other mucosal sites and determining the unique functions of tissue-resident memory lymphocyte subsets during secondary infection. Her lab is utilizing these findings to improve CD8+ T cell functionality in the context of colorectal cancer immunotherapy. This work is funded by a National Cancer Institute Career Development Award (K22).
Meet Yosuke Kumamoto, PhD
Yosuke Kumamoto, PhD, assistant professor of pathology and laboratory medicine, studies the role of dendritic cell subsets in adaptive immunity and inflammation. He obtained his PhD from the University of Tokyo and began his training as a biochemist studying the molecular function of mammalian C-type lectins, but later became interested in cellular immunology of cells expressing those lectins. In 2007 he moved to Yale University, where he found that a subset of dendritic cells expressing a C-type lectin CD301b/MGL2 is selectively required for the differentiation of Th2 cells as well as for maintenance of metabolic homeostasis. His study on dendritic cells is currently supported by an R01 grant from the National Institute of Allergy and Infectious Diseases.
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