Education

PHD, 1984, University of Texas
BS, 1976, SUNY

Relevant Publications

Pfeiffer RM, Hildesheim A, Gail MH, Pee D, Chen CJ, Goldstein AM, Diehl SR. Robustness of inference on measured covariates to misspecification of genetic random effects in family studies. Genet Epidemiol. 24:14-23, 2003.

Weinstein SJ, Gridley G, Harty LC, Diehl SR, Brown LM, Winn DM, Bravo-Otero E, Hayes RB. Folate Intake, Serum Homocysteine and Methylenetetrahydrofolate Reductase (MTHFR) C677T Genotype Are Not Associated with Oral Cancer Risk in Puerto Rico. J. Nutr. 132: 762-767, 2002.

Zavras, A.I., Wu, T., Laskaris, G., Wang, Y-F., Cartsos, V., Segas, J., Lefantzis, D., Joshipura, K., Douglass, C.W., Diehl, S.R. Interaction between a single nucleotide polymorphism in the alcohol dehydrogenase 3 gene, alcohol consumption and oral cancer risk. International J. Cancer 97: 526-530, 2002.

Seltzer, Z., Wu, T., Max, M., Diehl, S.R. Mapping a gene for neuropathic pain-related behavior following peripheral neurectomy in the mouse. Pain. 93:101-106, 2001.

Zavras, A.I., Douglass, C.W., Joshipura, K., Wu, T., Laskaris, G., Petridou, E., Dokianakis, G., Segas, J., Lefantzi, D., Nomikos, P., Wang, Y.F., Diehl, S.R. Smoking and alcohol in the etiology of oral cancer: gender-specific risk profiles in the south or Greece. Oral Oncology 37: 28-35, 2001.

Diehl, S.R., Wang, Y.-F., Brooks, C.N., Califano, J.V., Wang, S., Schenkein, H.A.: Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis. J. Perio. 70:418-430, 1999.

Diehl, S.R., Erickson, R.P.: Genome scan for teratogen-induced clefting susceptibility loci in the mouse: Evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate Proceedings of the National Academy of Sciences of the United States of America 94:5231-5236, 1997.

Reynolds, J.E., Fletcher, J.A., Lytle, C.H., Nie, L., Morton, C.C., Diehl, S.R.: Molecular characterization of a 17q11.2 translocation in a malignant schwannoma cell line. Hum. Genetics 90:450-456, 1992.

Ziegle, J.S., Su, Y., Corcoran, K.P., Nie, L., Mayrand, P.E., Hoff, L.B., McBride, L.J., Kronick, M.N., Diehl, S.R.: Application of automated DNA sizing technology for genotyping microsatellite loci. Genomics 14:1026-1031, 1992.

Diehl, S.R., Boehnke, M., Erickson, R.P., Baxter, A.B., Bruce, M.A., Lieberman, J.L., Platt, D.J., Ploughman, L.M., Seiler, K.A., Sweet, A.M., Collins, F.S.: Linkage analysis of von Recklinghausen neurofibromatosis to DNA markers on chromosome 17. Genomics 1:361-363, 1987.

The Center for Pharmacogenomics and Complex Disease Reserach which I direct has a mission focused on high-throughput analysis of inherited genetic polymorphisms. We are implementing hardware and software systems capable of analysing over 100,000 single nucleotide polymorphisms (SNPs) per day. A key component of the Center is the Laboratory Information Management System (LIMS) designed to track these assays as they are processed using robotic liquid handling systems. Staff of the Center also have advanced capabilities in bioinformatics, statistics and computer science. The Center is designed to enhance opportunities for developing new studies in all areas of health through collaborations with clinicians, epidemiologists and basic scientists interested in SNP-based research approaches, including animal models. We currently have research studies of oral cancer (including pre-malignant lesions) and nasopharyngeal carcinoma, and we are developing a collaborative study of the pharmacogenomics of opioid side effects and analgesic response in advanced cancer pain.