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Department of Pharmacology, Physiology & Neuroscience

Steven W. Levison, Ph.D.


Professor
Director, Laboratory For Regenerative Neurobiology
Editor-in-Chief, Developmental Neuroscience

Department of Pharmacology, Physiology & Neuroscience
levisosw@njms.rutgers.edu
 
Laboratory

Cancer Research Center (CANCT)
195 South Orange Avenue Room H-1226

Phone: (973) 972-5162
Fax: (973) 972-2668

Biography

Overview

Steven W. Levison graduated from the University of Rochester, where he received a B.S. in Neuroscience in 1983. He completed a Ph.D. in Neurobiology in 1990 at UNC-Chapel Hill, followed by a postdoctoral fellowship in the Program in Neurobiology and Behavior at Columbia University. Dr. Levison joined the faculty of New Jersey Medical School in 2004 after 11 years on the faculty of the Penn State College of Medicine.  He presently holds the position of Professor in the Department of Pharmacology, Physiology and Neuroscience and Directs the Laboratory for Regenerative Neurobiology. Dr. Levison has authored over 90 peer-reviewed scientific articles and his research has been supported continuously for over 20 years by the NIH and state and non-profit foundations. He is recognized internationally for his pioneering studies that have established that there is a regenerative response from the endogenous neural stem cells of the subventricular zone to neonatal brain injury that leads to the production of new neurons and glia. The group of scientists who currently work with Dr. Levison is deciphering the signals that coordinate this regenerative response as well as on new strategies to protect the immature brain from injury.

 

Education

B.S., 1983, University of Rochester, Neuroscience, NY, Neuroscience
Ph.D., 1990, University of North Carolina at Chapel Hill, NC, Neurobiology

 

Curriculum Vitae

View CV

 

 

Publications

Relevant Publications:

Krista D. Buono, Matthew T. Goodus, Mariano Guardia Clausi, Yuhui Jiang, Dean F. Loporchio and Steven W Levison (2015) Mechanisms of Murine Neural Precursor Expansion after Neonatal Hypoxia/Ischemia. Journal of Neuroscience, 35(23):8855-8865. PMID: 26063918
Mariano Guardia Clausi and Steven W. Levison (2016) “Delayed ALK5 inhibition improves functional recovery in neonatal brain injury”. Journal of Cerebral Blood Flow and Metabolism, 2016 Mar 16. pii: 0271678X16638669. PMID: 26984936
Amber N. Ziegler, Joel S. Schneider, Mei Qin, William A. Tyler, John E. Pintar, Diego Fraidenraich, Teresa L. Wood* and Steven W. Levison* (2012). IGF-II promotes stemness of neural restricted precursors Stem Cells, Jun;30(6):1265-76. PMID: 22593020
Matthew V. Covey, Dean F. Loporchio, Krista D. Buono and Steven W Levison (2011) Opposite Effect Of Inflammation on SVZ vs. Hippocampal Precursors In Brain Injury. Annals of Neurology, 70(4):616- 26. doi: 10.1002/ana.22473. Epub 2011 Jun 27. PMID: 21710624
Christine Y. Brazel, Ryan P. Felling and Steven W. Levison (2013) Molecular Features of Neural Stem Cells Enable their Enrichment Using Pharmacological Inhibitors of Survival-Promoting Kinases. J. Neurochem. PMID: 24032666
Jennifer M. Bain, Amber Ziegler, Zhengang Yang, Steven W Levison* and Ellora Sen* (2010) TGFß1 stimulates the over-production of white matter astrocytes from precursors of the “brain marrow” in a rodent model of neonatal encephalopathy. PLoS ONE 5(3): e9567. doi:10.1371/journal.pone.0009567. PMID: 20221422.
Nolan B. Skop, Frances Calderon, Cheul H. Cho, Chirag D. Gandhi, and Steven W. Levison (2014) Optimizing A Multifunctional Microsphere Scaffold To Improve Neural Precursor Cell Transplantation For Traumatic Brain Injury Repair. J. Tissue Engineering and Regenerative Medicine, doi: 10.1002/term.1832.
William Tyler, Nitish Gangoli, Pradeepa Gokina, Haesun A. Kim, Matthew V. Covey, Steven W. Levison and Teresa L. Wood (2009) Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. Journal of Neuroscience 9(19):6367-78. PMID: 19439614. Featured in This week in the Journal.
Matthew T. Goodus, Nadine A. Kerr, Ruchika Talwar, David Buziashvili, Jennifer Catuzzi, Kevin Pang and Steven W. Levison (2016) LIF Haplodeficiency Desynchronizes Glial Reactivity, Prolonging Damage And Worsening Functional Deficits After a Concussive Brain Injury. J. Neurotrauma. PMID: 26541248.
Mammalian Subventricular Zones: Their Roles in Brain Development, Cell Replacement and Disease (2005) S. W. Levison (Ed.). Springer, New York, NY. http://www.springer.com/sgw/cda/frontpage/0,11855,4-131-22-55007547-0,00.html

 

Current Research

Director, Laboratory for Regenerative Neurobiology

Dr. Levison is recognized internationally for his pioneering studies that have established that
there is a regenerative response from the endogenous neural stem cells of the subventricular zone to
neonatal hypoxic/ischemic brain injury that leads to the production of new neurons and glia. The group of
scientists who currently work with Dr. Levison is testing strategies to enhance regeneration of the CNS by
stimulating the resident stem cells that reside within the “brain marrow" to stimulate repair after neonatal stroke
and pediatric traumatic brain injury.



 

 

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