245. Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K,Levine B, Sadoshima J. Drp1-Dependent Mitochondrial Autophagy Plays a ProtectiveRole Against Pressure Overload-Induced Mitochondrial Dysfunction and HeartFailure. Circulation. 2016; 133(13):1249-63. NIHMSID: NIHMS759008 PubMed[journal] PMID: 26915633, PMCID: PMC4811679

244. Tong M, Sadoshima J. Mitochondrial autophagy in cardiomyopathy. Current opinionin genetics & development. 2016; 38:8-15. PubMed [journal] PMID: 27003723


243. Maejima Y, Isobe M, Sadoshima J. Regulation of autophagy by Beclin 1 in theheart. Journal of molecular and cellular cardiology. 2015; PubMed [journal] PMID:26546165

242. Matsushima S, Sadoshima J. The role of sirtuins in cardiac disease. Americanjournal of physiology. Heart and circulatory physiology. 2015; 309(9):H1375-89.PubMed [journal] PMID: 26232232, PMCID: PMC4666968

241. Oka S, Zhai P, Yamamoto T, Ikeda Y, Byun J, Hsu CP, Sadoshima J. PeroxisomeProliferator Activated Receptor-α Association With Silent Information Regulator 1Suppresses Cardiac Fatty Acid Metabolism in the Failing Heart. Circulation. Heart
failure. 2015; 8(6):1123-32. NIHMSID: NIHMS728912 PubMed [journal] PMID:26443578, PMCID: PMC4651813

240. Yang Y, Del Re DP, Nakano N, Sciarretta S, Zhai P, Park J, Sayed D, Shirakabe A, Matsushima S, Park Y, Tian B, Abdellatif M, Sadoshima J. miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival. Circ Res. 2015 Sep 2. pii: CIRCRESAHA.115.306624. [Epub ahead of print] PubMed PMID: 26333362.

239. Matsushima S, Sadoshima J. The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol. 2015 Jul 31:ajpheart.00053.2015. doi: 10.1152/ajpheart.00053.2015. [Epub ahead of print] PubMed PMID: 26232232.

238. Ago T, Sadoshima J. From Contractile Enhancement to Pathological Hypertrophy: Angiotensin II-Induced Nox2-Mediated Reactive Oxygen Species. J Am Coll Cardiol. 2015 Jul 21;66(3):273-7. doi: 10.1016/j.jacc.2015.05.058. PubMed PMID: 26184621.

237. Zablocki D, Sadoshima J. Inside-Out Signaling: Moving the AT1 Receptor in to Get the Message Out. Circulation. 2015 Jun 16;131(24):2097-100. doi: 10.1161/CIRCULATIONAHA.115.016978. Epub 2015 May 20. PubMed PMID: 25995314; PubMed Central PMCID: PMC4470784.

236. Saito T, Sadoshima J. Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart. Circ Res. 2015 Apr 10;116(8):1477-90. doi: 10.1161/CIRCRESAHA.116.303790. Review. PubMed PMID: 25858070; PubMed Central PMCID: PMC4419704.

235. Sciarretta S, Zhai P, Maejima Y, Del Re DP, Nagarajan N, Yee D, Liu T, Magnuson MA, Volpe M, Frati G, Li H, Sadoshima J. mTORC2 regulates cardiac response to stress by inhibiting MST1. Cell Rep. 2015 Apr 7;11(1):125-36. doi: 10.1016/j.celrep.2015.03.010. Epub 2015 Apr 2. PubMed PMID: 25843706; PubMed Central PMCID: PMC4417361.

234. Sciarretta S, Yee D, Ammann P, Nagarajan N, Volpe M, Frati G, Sadoshima J. Role of NADPH oxidase in the regulation of autophagy in cardiomyocytes. Clin Sci (Lond). 2015 Apr;128(7):387-403. doi: 10.1042/CS20140336. PubMed PMID: 25515000.\

233. Tzeng J, Byun J, Park JY, Yamamoto T, Schesing K, Tian B, Sadoshima J, Oka S. An Ideal PPAR Response Element Bound to and Activated by PPARα. PLoS One. 2015 Aug 4;10(8):e0134996. doi: 10.1371/journal.pone.0134996. eCollection 2015. PubMed PMID: 26241474; PubMed Central PMCID: PMC4524655.


232. Sapra G, Tham YK, Cemerlang N, Matsumoto A, Kiriazis H, Bernardo BC, Henstridge DC, Ooi JY, Pretorius L, Boey EJ, Lim L, Sadoshima J, Meikle PJ, Mellet NA, Woodcock EA, Marasco S, Ueyama T, Du XJ, Febbraio MA, McMullen JR. The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.Nat Commun. 2014 Dec 9;5:5705. doi: 10.1038/ncomms6705.PMID: 25489988 [PubMed - in process]

231. Nakamura M, Sadoshima J. Heart over mind: metabolic control of white adipose tissue and liver.EMBO Mol Med.2014 Dec 3;6(12):1521-4. doi: 10.15252/emmm.201404749. No abstract available. PMID: 25471454 [PubMed - in process] Free Article

230. Moyzis AG, Sadoshima J, Gustafsson AB. Mending a Broken Heart: The Role of Mitophagy in Cardioprotection.Am J Physiol Heart Circ Physiol.2014 Nov 26:ajpheart.00708.2014. doi: 10.1152/ajpheart.00708.2014. [Epub ahead of print]

229. Maejima Y, Chen Y, Isobe M, Gustafsson AB, Kitsis RN, Sadoshima J. Recent Progress in Research on Molecular Mechanisms of Autophagy in the Heart.Am J Physiol Heart Circ Physiol.2014 Nov 1

228. Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, Abdellatif M, Sadoshima J. Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress.Circ Res.2014 Oct 20.

227. Chen L, Hou X, Xiao J, Kuroda J, Ago T, Sadoshima J, Cohen RA, Tong X. Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines.Biochim Biophys Acta.2014 Oct 11.

226. Ikeda Y, Shirakabe A, Brady C, Zablocki D, Ohishi M, Sadoshima J. Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system.J Mol Cell Cardiol.2014 Oct 7.

225. Hsu CP, Yamamoto T, Oka S, Sadoshima J. The function of nicotinamide phosphoribosyltransferase in the heart.DNA Repair (Amst).2014
Sep 29.

224. Maejima Y, Sadoshima J. SUMOylation: a novel protein quality control modifier in the heart.Circ Res.2014 Sep 26;115(8):686-9.

223. Wu C, Jain MR, Li Q, Oka SI, Li W, Kong AN, Nagarajan N, Sadoshima J, Simmons WJ, Li H. Identification of Novel Nuclear Targets of Human Thioredoxin 1.Mol Cell Proteomics.2014 Sep 17. pii: mcp.M114.040931. [Epub ahead of print] PMID: 25231459 [PubMed - as supplied by publisher] Free Article

222. Ikeda Y, Sciarretta S, Nagarajan N, Rubattu S, Volpe M, Frati G, Sadoshima J. New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart.Oxid Med Cell Longev.2014;2014:210934.Free PMCArticle

221. Wackerhage H, Del Re DP, Judson RN, Sudol M, Sadoshima J. The Hippo signal transduction network in skeletal and cardiac muscle.Sci Signal.2014 Aug 5;7(337):re4.

220. Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J, Guan KL. Rag GTPases are cardioprotective by regulating lysosomal function.Nat Commun.2014 Jul 1;5:4241.

219. Hasumi Y, Baba M, Hasumi H, Huang Y, Lang M, Reindorf R, Oh HB, Sciarretta S, Nagashima K, Haines DC, Schneider MD, Adelstein RS, Schmidt LS, Sadoshima J, Linehan WM.Hum Mol Genet.2014 Jun 6.

218. Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S, Sadoshima J. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion.PLoS One.2014 Jun 6;9(6):e98972.Free PMCArticle

217. Lee A, Jeong D, Mitsuyama S, Oh JG, Liang L, Ikeda Y, Sadoshima J, Hajjar R, Kho C. The Role of SUMO-1 in Cardiac Oxidative Stress and Hypertrophy.Antioxid Redox Signal.2014 Jun 3.

216. Matsushima S, Tsutsui H, Sadoshima J. Physiological and pathological functions of NADPH oxidases during myocardial ischemia-reperfusion.Trends Cardiovasc Med.2014 Apr 1.

215. Del Re DP, Matsuda T, Zhai P, Maejima Y, Jain MR, Liu T, Li H, Hsu CP, Sadoshima J. Mst1 Promotes Cardiac Myocyte Apoptosis through Phosphorylation and Inhibition of Bcl-xL.Mol Cell.2014 May 22;54(4):639-50.

214. Del Re DP, Sadoshima J. Elucidating ERK2 function in the heart.J Mol Cell Cardiol.2014 Jul;72:336-8.

213. Sadoshima J, Weiss JN. Cardiac fibroblasts: the good, the bad, the ugly, the beautiful.J Mol Cell Cardiol.2014 May;70:1.

212. Maejima Y, Usui S, Zhai P, Takamura M, Kaneko S, Zablocki D, Yokota M, Isobe M, Sadoshima J. Muscle-Specific RING Finger 1 Negatively Regulates Pathological Cardiac Hypertrophy Through Downregulation of Calcineurin A.Circ Heart Fail.2014 May;7(3):479-90.

211. Shao D, Zhai P, Del Re DP, Sciarretta S, Yabuta N, Nojima H, Lim DS, Pan D, Sadoshima J. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response.Nat Commun.2014;5:3315.Free PMC Article

210. Shao D, Oka S, Liu T, Zhai P, Ago T, Sciarretta S, Li H, Sadoshima J. A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation.Cell Metab. 2014 Feb 4;19(2):232-45.

209. Sciarretta S, Volpe M, Sadoshima J. NOX4 regulates autophagy during energy deprivation.Autophagy.2014 Apr;10(4):699-701.

208. Sciarretta S, Volpe M, Sadoshima J. Mammalian target of rapamycin signaling in cardiac physiology and disease.Circ Res.2014 Jan 31;114 (3):549-64.

207. Yu Q, Lee CF, Wang W, Karamanlidis G, Kuroda J, Matsushima S, Sadoshima J, Tan R. Elimination of NADPH oxidase activity promotes reductive stress and sensitizes he heart to ischemic njury.J Am Heart Assoc.2014 Jan 27;3(1):e000555. doi: 10.1161/JAHA.113.000555.PMID: 24470522 Free PMC Article


206. Sciarretta S, Yee D, Shenoy V, Nagarajan N, Sadoshima J. The Importance of Autophagy in Cardioprotection.High Blood Press Cardiovasc Prev.2013 Nov 14. [Epub ahead of print] PMID: 24235024

205. Zablocki D, Sadoshima J. Solving the cardiac hypertrophy riddle: The angiotensin II-mechanical stress connection.Circ Res.2013 Nov 8;113 (11):1192-5. doi: 10.1161/CIRCRESAHA.113.302501. PMID: 24201113

204. Banerjee Mustafi S, Grose JH, Zhang H, Pratt GW, Sadoshima J, Christians E, Benjamin I. Aggregate-prone R120GCRYAB triggers multifaceted modifications of the Thioredoxin System.Antioxid Redox Signal.2013 Nov 1. PMID: 24180415

203. Bhuiyan MS, Pattison JS, Osinska H, James J, Gulick J, McLendon PM, Hill JA, Sadoshima J, Robbins J. Enhanced autophagy ameliorates cardiac proteinopathy.J Clin Invest.2013 Dec 2;123(12):5284-97. doi: 10.1172/JCI70877. Epub 2013 Nov 1. PMID: 24177425 Free PMC Article

202. Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S, Del Re DP, Zablocki DK, Hsu CP, Lim DS, Isobe M, Sadoshima J. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2.Nat Med. 2013 Oct 20. doi: 10.1038/nm.3322.

201. Weiss CS, Ochs MM, Hagenmueller M, Streit MR, Malekar P, Riffel JH, Buss SJ, Weiss KH, Sadoshima J, Katus HA, Hardt SE. DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3β on eIF2B.PLoSOne.2013 Sep 4;8(9):e70848. doi: 10.1371 /journal.pone.0070848.PMID: 24023715 Free PMC Article

200. Lavandero S, Troncoso R, Rothermel BA, Martinet W, Sadoshima J, Hill JA. Cardiovascular autophagy: Concepts, controversies and perspectives.Autophagy.2013 Aug 14;9(10).

199. Sciarretta S, Zhai P, Shao D, Zablocki D, Nagarajan N, Terada LS, Volpe M, Sadoshima J. Activation of Nox4 in the Endoplasmic Reticulum Promotes Cardiomyocyte Autophagy and Survival During Energy Stress Through the PERK/eIF-2α/ATF4 Pathway.Circ Res.2013 Sep 30.

198. Sciarretta S, Marchitti S, Bianchi F, Moyes A, Barbato E, Di Castro S, Stanzione R, Cotugno M, Castello L, Calvieri C, Eberini I, Sadoshima J, Hobbs AJ, Volpe M, Rubattu S. C2238 atrial natriuretic peptide molecular variant is associated with endothelial damage and dysfunction through natriuretic peptide receptor C signaling.Circ Res.2013 May 10;112(10):1355-64.

197. Matsushima S, Kuroda J, Ago T, Zhai P, Ikeda Y, Oka S, Fong GH, Tian R, Sadoshima J. Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1α and upregulation of peroxisome proliferator-activated receptor-α.Circ Res. 2013 Apr 12;112(8):1135-49.

196. Nicholson CK, Lambert JP, Molkentin JD, Sadoshima J, Calvert JW. Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure.Arterioscler Thromb Vasc Biol.2013 Apr;33(4):744-51. doi: 10.1161/ATVBAHA.112.300484. Epub 2013 Jan 24.

195. Hariharan N, Ikeda Y, Hong C, Alcendor RR, Usui S, Gao S, Maejima Y, Sadoshima J. Autophagy Plays an Essential Role in Mediating Regression of Hypertrophy during Unloading of the Heart.PLoS One. 2013;8(1):e51632. doi: 10.1371/journal.pone.0051632. Epub 2013 Jan 7. PMID: 23308102 Free PMC Article


194. Del Re DP, Yang Y, Nakao N, Cho J, Zhai P, Yamamoto T, Zhang N, Yabuta N, Nojima H, Pan D, Sadoshima J. Yes-associated protein isoform 1 (ap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury.J Biol Chem.2012 Dec 30.Free Article

193. Matsushima S, Kuroda J, Ago T, Zhai P, Park JY, Xie LH, Tian B, Sadoshima J. Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy.Circ Res. 2012 Dec 27.

192. Brody MJ, Hacker TA, Patel JR, Feng L, Sadoshima J, Tevosian SG, Balijepalli RC, Moss RL, Lee Y. Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (lrrc10) results in dilated cardiomyopathy.PLoS One. 2012;7(12):e51621. doi: 10.1371/journal.pone.0051621. Epub 2012 Dec 7.PMID: 23236519.Free Article

191. Sadoshima J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy.Autophagy. 2012 Apr;8(4):445-544.

190. Maejima Y, Galeotti J, Molkentin JD, Sadoshima J, Zhai P. Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload.Am J Physiol Heart Circ Physiol.2012 Oct;303(8):H979-88.Free PMC Article

189. Oka S, Hsu CP, Sadoshima J. Regulation of cell survival and death by pyridine nucleotides.Circ Res.2012 Aug 17;111(5):611-27.

188. Nakamura M, Bhatnagar A, Sadoshima J. Overview of pyridine nucleotides review series.Circ Res.2012 Aug 17;111(5):604-10.

187. Zschauer TC, Matsushima S, Altschmied J, Shao D, Sadoshima J, Haendeler J. Interacting with Thioredoxin-1-Disease or No Disease?Antioxid Redox Signal.2012 Sep 24. [Epub ahead of print]

186. Sciarretta S, Zhai P, Volpe M, Sadoshima J. Pharmacological modulation of autophagy during cardiac stress.J Cardiovasc Pharmacol.2012 Sep;60(3):235-41.

185. Del Re DP, Sadoshima J.RASSF1A Signaling in the Heart: Novel Functions beyond Tumor Suppression.Mol Biol Int.2012;2012:154283. Epub 2012 Apr 10.Free PMC Article

184. Sciarretta S, Volpe M, Sadoshima J.Is reactivation of autophagy a possible therapeutic solution for obesity and metabolic syndrome?Autophagy.2012 Aug 1;8(8). [Epub ahead of print]

183. Del Re DP, Sadoshima J.Enhancing the potential of cardiac progenitor cells: pushing forward with pim-1.Circ Res.2012 Apr 27;110(9):1154-6.

182. Zablocki D, Sadoshima J. Angiotensin II and Oxidative Stress in the Failing Heart.Antioxid Redox Signal.2012 May 3. [Epub ahead of print]

181. Oka SI, Zhai P, Alcendor R, Park JY, Tian B, Sadoshima J.Suppression of ERR targets by a PPARα/Sirt1 complex in the failing heart.Cell Cycle. 2012 Mar 1;11(5). [Epub ahead of print]

180. Sciarretta S, Zhai P, Shao D, Maejima Y, Robbins J, Volpe M, Condorelli G, Sadoshima J.Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome.Circulation.2012 Mar 6;125(9):1134-46. doi: 10.1161 /CIRCULATIONAHA.111.078212. Epub 2012 Jan 31.CirculationEditors' PicsFree Article

179. Messaoudi S, Zhang AD, Griol-Charhbili V, Escoubet B, Sadoshima J, Farman N, Jaisser F.The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling.PLoS One.2012;7(1):e30156. Epub 2012 Jan 23.Free PMC Article

178 Zhai P, Sadoshima J. Glycogen synthase kinase-3β controls autophagy during myocardial ischemia and reperfusion.Autophagy.2012 Jan;8 (1):138-9. Epub 2012 Jan 1.Free PMC Article

177. Shao D, Oka SI, Brady CD, Haendeler J, Eaton P, Sadoshima J. Redox modification of cell signaling in the cardiovascular system.J Mol Cell Cardiol.2012 Mar;52(3):550-8. Epub 2011 Sep 17.


176. Sadoshima J, Hare JM. Meeting report for basic cardiovascular sciences 2011 scientific sessions: from concept to clinic: leading cardiovascular translational science.Circ Res.2011 Nov 11;109(11):1204-5.Free Article

175. Oka S, Alcendor R, Zhai P, Park JY, Shao D, Cho J, Yamamoto T, Tian B, Sadoshima J. PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway.Cell Metab.2011 Nov 2;14(5):598-611.Free ArticlePress Release Summary in Japanese

174. Sciarretta S, Zablocki D, Sadoshima J. New insights into the role and regulation of autophagy during myocardial ischemia.High Blood Pressure & Cardiovascular Prevention.2011.

173. Park JY, Li W, Zheng D, Zhai P, Zhao Y, Matsuda T, Vatner SF, Sadoshima J, Tian B. Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules.PLoS One. 2011;6(7):e22391.Free Article

172. Zhai P, Sciarretta S, Galeotti J, Volpe M, Sadoshima J. Differential Roles of GSK-3{beta} During Myocardial Ischemia and Ischemia/Reperfusion.Circ Res.2011 Aug 19;109(5):502-11. Epub 2011 Jul 7.Free Article

171. Wu C, Parrott AM, Liu T, Jain MR, Yang Y, Sadoshima J, Li H. Distinction of thioredoxin transnitrosylation and denitrosylation target proteins by the ICAT quantitative approach.J Proteomics.2011 Jun 17.Free Article

170. Ago T, Kuroda J, Kamouchi M, Sadoshima J, Kitazono T. Pathophysiological roles of NADPH oxidase/nox family proteins in the vascular system.Circ J.2011 Jul 25;75(8):1791-800. Epub 2011 Jun 15.Free Article

169. Usui S, Maejima Y, Pain J, Hong C, Cho J, Park JY, Zablocki D, Tian B, Glass DJ, Sadoshima J. Endogenous Muscle Atrophy F-Box Mediates Pressure Overload-Induced Cardiac Hypertrophy Through Regulation of Nuclear Factor-{kappa}B.Circ Res.2011 Jul 8;109(2):161-71. Epub 2011 May 26.Free Article

168. Del Re DP, Sadoshima J. Is Raf1 a nexus for cardiac hypertrophic signaling in human disease?J Mol Cell Cardiol.2011 Jul;51(1):1-3. Epub 2011 Apr 22.

167. Wu C, Parrott AM, Fu C, Liu T, Marino SM, Gladyshev VN, Jain MR, Baykal AT, Li Q, Oka S, Sadoshima J, Beuve A, Simmons WJ, Li H. Thioredoxin 1-Mediated Post-Translational Modifications: Reduction.Transnitrosylation. Antioxid Redox Signal.2011 Nov 1;15(9):2565-604. Epub 2011
Jun 8.Free Article

166. Lin YR, Kim K, Yang Y, Ivessa A, Sadoshima J, Park Y. Regulation of longevity by regulator of G-protein signaling protein, Loco.Aging Cell. 2011 Jun;10(3):438-47. doi: 10.1111/j.1474-9726.2011.00678.x. Epub 2011 Mar 22.

165. Sadoshima J. Sirt3 Targets mPTP and Prevents Aging in the Heart.AGING,2011 Jan;3(1):12-3. FreeArticle

164. Zablocki D, Sadoshima J. Knocking Out Angiotensin II in the Heart.Curr Hypertens Rep.2011 Apr;13(2):129-35. Review.Free Article

163. Cho J, Zhai P, Maejima Y, Sadoshima J. Myocardial Injection With GSK-3{beta}-Overexpressing Bone Marrow-Derived Mesenchymal Stem Cells Attenuates Cardiac Dysfunction After Myocardial Infarction.Circ Res.2011 Feb 18;108(4):478-89.FreeArticle.One of Ten Most Read ArticlesPublished inCirculation Researchin 2011

162. Yamamoto T, Sadoshima J. Protection of the heart against ischemia/reperfusion by silent information regulator 1.Trends Cardiovasc Med.2011 Jan;21(1):27-32.Free Article

161. Maejima Y, Kuroda J, Matsushima S, Ago T, Sadoshima J. Regulation of myocardial growth and death by NADPH oxidase.J Mol Cell Cardiol.2011 Mar;50(3):408-16. Epub 2011 Jan 6. Review.Free Article


160. Ago T, Matsushima S, Kuroda J, Zablocki D, Kitazono T, Sadoshima J. The NADPH Oxidase Nox4 and Aging in the Heart.AGING(Albany NY). 2010 Dec;2(12):1012-6.Free Article

159. Yang Y, Ago T, Zhai P, Abdellatif M, Sadoshima J. Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.Circ Res.2011 Feb 4;108(3):305-13.Free Article

158. Sciarretta S, Hariharan N, Monden Y, Zablocki D, Sadoshima J. Is Autophagy in Response to Ischemia and Reperfusion Protective or Detrimental for the Heart?Pediatr Cardiol.2011 Mar;32(3):275-81.Free Article

157. Zhao Q, Beck AJ, Vitale JM, Schneider JS, Chang C, Gao S, Del Re D, Bhaumik M, Yehia G, Sadoshima J, Fraidenraich D. Injection of Wild Type Embryonic Stem Cells into Mst1 Transgenic Blastocysts Prevents Adult-Onset Cardiomyopathy.Stem Cell Rev. 2010 Nov 18. 2011 Jun;7(2):326-30.Free Article

156. Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J. 2010. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes.Cir Res.Dec 10;107(12):1470-82.Free Article<Best Manuscript Award>

155. Matsushima S, Zablocki D, Sadoshima J. 2010. Application of Recombinant Thioredoxin1 for Treatment of Heart Disease.J Mol Cell Cardiol.Oct 16.Free Article

154. Hsu CP, Zhai P, Yamamoto T, Maejima Y, Matsushima S, Harinaran N, Shao D, Takagi H, Oka S, Sadoshima J. Silent information regulator 1 protects the heart from ischemia/reperfusion.Circulation, 2010. Nov 23;122(21):2170-82.Free Article

153. Kajimoto K, Shao D, Takagi H, Maceri G, Zablocki D, Mukai H, Ono Y, Sadoshima J. 2010. Hypotonic swelling-induced activation of PKN mediates cell survival in cardiac myocytes.Am J Physiol Heart Circ Physiol2011 Jan;300(1):H191-200.FreeArticle

152. Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. 2010. Dietary restriction: standing up for sirtuins. Science.2010 Aug 27;329(5995):1012-3.

151. Del Re, D.P., Matsuda, T., Zhai P., Gao S., Clark, G.J., van der Weyden, L., Sadoshima, J. 2010. Proapoptotic Rass1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice.J. Clin. Invest.Oct 1;120(10):3555-67.Free Article

150. Kuroda, J., Ago, T., Matsushima, S., Zhai P., Scheneider, M.D., Sadoshima, J., 2010. Nox4 is a major source of oxidative stress in the failing heart.Proc Natl Acad Sci USA.Aug 31;107(35):15565-70.Free Article

149. Hariharan, N., Zhai, P., Sadoshima, J. 2010. Oxidative stress stimulates autophagic flux during ischemia/reperfution.Antioxid Redox Signal.Sep 2.Free Article

148. Wu, C., Liu, T., Chen, W., Oka, S., Fu, C., Jain, M.R., Parrott, A.M., Baykal, A.T., Sadoshima, J., Li, H. 2010. Redox regulatory mechanism of transnytrosylation by thioredoxin.Mol Cell Proteomics.Oct;9(10):2262-75.Free Article

147. Takagi, H., Hsu, C.-P., Kajimoto, K., Shao, D., Yang, Y., Maejima, Y., Zhai, P., Yeshia, G., Yamada, C., Zablocki, D., Sadoshima, J. 2010. Activation of PKN Mediates Survival of Cardiac Myocytes in the Heart During Ischemia/Reperfusion.Circ Res.Sep 3;107(5):642-9.Free Article

146. Kuroda, J., Sadoshima, J. 2010. NADPH oxidase and cardiac failure.J Cardiovasc Transi Res.3(4)314-20.Free Article

145. Sciarretta, S., Sadoshima, J. 2010. New insights into the molecular phenotype of eccentric hypertrophy.J Mol Cell Cardiol.49(2):153-4.FreeArticle

144. Haldar, S.M., Lu, Y., Jeyaraj, D., Kawanami, D., Cui, Y., Eapen, S.J., Hao, C., Li, Y., Doughman, Y.Q., Watanabe, M., Shimizu, K., Kuivaniemi, H., Sadoshima, J., Margulies, K.B., Cappola, T.P., Jain, M.K. 2010. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.Sci Transl Med.7;2(26):26ra26.Free Article

143. Zablocki, D., Sadoshima, J. 2010. The one-two punch: knocking out angiotensin II in the heart.J. Clin. Invest.120(4):1028-31.Free Article

142. Ago, T., Yang, Y., Zhai, P., Sadoshima, J. 2010. Nifedipine Inhibits Cardiac Hypertrophy and Left Venticular Dyfunction in Response to Pressure Overload.J Cardiovascular Translational Research.3(4):304-13.Free Article

141. Ago, T., Kuroda, J., Pain, J., Fu, C., Li, H., Sadoshima, J. 2010. Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes.Cir Res.106(7):1253-64.Free Article

140. Chu, P.Y.,Mariani, J., Finch, S., McMullen, J.R., Sadoshima, J., 2010. Bone Marrow-Derived Cells Contribute of Fibrosis in the Chronically Failing Heart.Am J Pathol.176(4):1735-42.Free Article


139. Hsu, C.P., Hariharan, N., Alcendor, R.N., Oka, S. and Sadoshima, J. 2009. Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes.Autophasy5(8):1229-31.

138. Cho, J., Rameshwar, P. and Sadoshima, J. 2009. Distrinct Roles of GSK-3 and GSK-3β in Mediating Cardiomyocyte Differentiation in Murine Bone Marrow Delived Mesenchymal Stem Cells.J. Biol. Chem.284(52):36647-58.

137. Hu, C.L., Chandra, R., Ge, H., Pain, J., Yan, L., Babu, G.J., Depre, D., Iwatsubo, K., Ishikawa, Y., Sadohsima, J., Vatner, S.F., Vatner, D.F. 2009. Adenylyl Cyclase Type 5 Protein Expression during Cardiac Development and Stress.Am J Physio Heart Circ Physiol.297(5):H1776-82.

136. Woodcock, E.A., Grubb, D.R., Flitz, T.M., Marasco, S., Luo, J., McLeod-Dryden, T.J., Kaye, D.M., Sadoshima, J., Du, X.J., Wong, C., McMullen, J.R., Dart, A.M. 2009 Selective Activation of the "B"splice Variant of Phospholipase Cbeta1 in Chronically Dilated Human Mouse Atria.J Mol Cell Cardiol47 (5):676-83.

135. Gelpi, R.J., Gao, S., Zhai, P., Yan, L., Hong, C., Danridge, L.A., Ge, H., Maejima, Y., Donato, M., Yokota, M., Molkentin, J.D., Vatner, D.E., Vatner, S. F., Sadoshima, J. 2009 Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload.Am J Physiol Heart Circ Physiol.297(5):H1814-9.

134. Del Re, D.P., Sadoshima, J. 2009. Optimizing cell-based therapy for cardiac regeneration.Circulation.120(10):831-4.

133. Pretorius, L., Du, X.J., Woodcock, E.A,. Kiriazis,H., Lin, R.C., Marasco, S., Medcalf, R.L., Ming, Z., Head, G.A., Tan, J.W., Cemerlang, N., Sadoshima, J., Shioi, T., Izumo, S., Lukoshkova, E.V., Dart, A.M., Jennings,G.L., McMullen, J.R. 2009. Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation.Am J Pathol.175(3):998-1009.

132. Hsu, C.P., Oka, S., Shao, D., Hariharan, N., Sadoshima, J. 2009. Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes.Circ Res.28;105(5):481-91.

131. Wu, C., Yan, L., Depre, C., Dhar, S.K., Shen, Y.T., Sadoshima, J., Vatner, S.F., Vatner, D.E. Cytochrome C oxidase III as a mechanism for apoptosis in heart failure folloing myocardial infraction.Am J Physiol Cell Physiol.297(4):C928-34.

130. Bellis, A., Castaldo, D., Trimarco, V., Monti, M.G., Chivasso, P., Sadoshima, J., Trimarco, B., Morisco, C. 2009 Cross-talk between PKA and Akt protects endothelial cells from apoptosis in the late inschemic preconditioning.Arterioscler Thromb Vasc Biol.29(8):1207-12.

129. Yan, L., Sadoshima, J., Vatner, D.E., Vatner, S.F. 2009. Autophagy in ischemic preconditioning and hibernating myocardium.Autophagy.5(5): 709-12.

128. Fu, C., Wu, C., Liu, T., Ago, T., Zhai, P., Sadoshima, J., Li, H. 2009. Elucidation of thioredoxin target protein networks in mouse.Mol Cell Proteomics. 8(7):1674-87.

127. Oka, S., Ago, T., Kitazono,T., Zablocki, D., Sadoshima, J. 2009. The Role of Redox Modulation of Class II Histone Deacetylases in Mediating Pathological Cardiac Hypertrophy.Journal of Molecular Medicine.87(8):785-91.

126. Rane, S., He, M., Sayed, D., Vashistha, H., Malhotra, A., Sadoshima, J., Vatner, D.E., Vatner, S.F., Adbellatif, M. 2009. Downregulation of MiR- 199a Depresses Hypoxia-Inducible Factor-1{alpha} and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes.Circ Res.104(7):879-

125. Nishida, K., Kyoi, S., Yamaguchi, O., Sadoshima, J., Otsu, K. 2009. The role of autophagy in the heart.Cell Death Differ.16(1):31-38.

124. Perry, C.N., Kyoi, S., Hariharan, N., Takagi, H., Sadoshima, J., Gottlieb, R.A. 2009. Novel methods for measuring cardiac autophagy in vivo.Methods in Enzymology.453:325-342.

123. Vatner, F.S., Yan, L., Ishikawa, Y., Vatner, E.D., and Sadoshima, J. 2009. Adenylyl Cyclase Type 5 Disruption Prolongs Longivity and Protects the Heart against Stress.Circ.J.73(2):195-200.


122. Ago, T., Liu, T., Zhai, P., Chen, W., Li, H., Molkentin, J.D., Vatner, S.F., and Sadoshima, J. 2008. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy.Cell133:978-993.

121. Fu, C., Hu, J., Liu, T., Ago, T., Sadoshima, J., and Li, H. 2008. Quantitative analysis of redox-sensitive proteome with DIGE and ICAT.J Proteome Res7:3789-3802.

120. Hsu, C.P., Odewale, I., Alcendor, R.R., and Sadoshima, J. 2008. Sirt1 protects the heart from aging and stress.Biol Chem389:221-231.

119. Klionsky, D.J., Abeliovich, H., Agostinis, P. et al (JS is 168th out of 236 authors) 2008. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.Autophagy4:151-175.

118. Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto H, Takagi H, Tamamoti-Adachi T, Kitajima S, Sadoshima J. Phosphorylation of GSK-3ais essential for myocyte proliferation in the heart under pressure overload.Proc Natl Acad Sci U S A. 2008; 105: 20900-20905.

117. Matsui, Y., Kyoi, S., Takagi, H., Hsu, C.P., Hariharan, N., Ago, T., Vatner, S.F., and Sadoshima, J. 2008. Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion.Autophagy4:409-415.

116. Matsui, Y., Nakano, N., Shao, D., Gao, S., Luo, W., Hong, C., Zhai, P., Holle, E., Yu, X., Yabuta, N., Tao, W., Wagner, T., Nojima, H., and Sadoshima, J. 2008. Lats2 is a negative regulator of myocyte size in the heart.Circ Res103:1309-1318.

115. Miyazaki, R., Ichiki, T., Hashimoto, T., Inanaga, K., Imayama, I., Sadoshima, J., and Sunagawa, K. 2008. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells.Arterioscler Thromb Vasc Biol28:1263-1269.

114. Morisco, C., Marrone, C., Galeotti, J., Shao, D., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2008. Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.Cardiovasc Res78:36-44.

113. Ohtsubo, H., Ichiki, T., Imayama, I., Ono, H., Fukuyama, K., Hashiguchi, Y., Sadoshima, J., and Sunagawa, K. 2008. Involvement of Mst1 in tumor necrosis factor-alpha-induced apoptosis of endothelial cells.Biochem Biophys Res Commun367:474-480.

112. Sadoshima, J. 2008. The role of autophagy during ischemia/reperfusion.Autophagy4:402-403.

111. Shen, Y.T., Depre, C., Yan, L., Park, J.Y., Tian, B., Jain, K., Chen, L., Zhang, Y., Kudej, R.K., Zhao, X., Sadoshima, J., Vatner, D.E., and Vatner, S. F. 2008. Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning.Circulation118:1961-1969.

110. Zhai, P., and Sadoshima, J. 2008. Overcoming an energy crisis?: an adaptive role of glycogen synthase kinase-3 inhibition in ischemia/reperfusion.Circ Res103:910-913.


109. Ago, T., and Sadoshima, J. 2007. Thioredoxin1 as a negative regulator of cardiac hypertrophy.Antioxid Redox Signal9:679-687.

108. Alcendor, R.R., Gao, S., Zhai, P., Zablocki, D., Holle, E., Yu, X., Tian, B., Wagner, T., Vatner, S.F., and Sadoshima, J. 2007. Sirt1 regulates aging and resistance to oxidative stress in the heart.Circ Res100:1512-1521.

107. Hirotani, S., Zhai, P., Tomita, H., Galeotti, J., Marquez, J.P., Gao, S., Hong, C., Yatani, A., Avila, J., and Sadoshima, J. 2007. Inhibition of glycogen synthase kinase 3beta during heart failure is protective.Circ Res101:1164-1174.

106. Matsui, Y., Takagi, H., Qu, X., Abdellatif, M., Sakoda, H., Asano, T., Levine, B., and Sadoshima, J. 2007. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.Circ Res100:914-922.

105. Morisco, C., Marrone, C., Trimarco, V., Crispo, S., Monti, M.G., Sadoshima, J., and Trimarco, B. 2007. Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression.Cardiovasc Res76:453-464.

104. Nishizawa, T., Shen, Y.T., Rossi, F., Hong, C., Robbins, J., Ishikawa, Y., Sadoshima, J., Vatner, D.E., and Vatner, S.F. 2007. Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha.Am J Physiol Heart Circ Physiol292:H971-975.

103. Odashima, M., Usui, S., Takagi, H., Hong, C., Liu, J., Yokota, M., and Sadoshima, J. 2007. Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.Circ Res100:1344-1352.

102. Ohtsubo, H., Ichiki, T., Miyazaki, R., Inanaga, K., Imayama, I., Hashiguchi, Y., Sadoshima, J., and Sunagawa, K. 2007. Inducible cAMP early repressor inhibits growth of vascular smooth muscle cell.Arterioscler Thromb Vasc Biol27:1549-1555.

101. Peter, P.S., Brady, J.E., Yan, L., Chen, W., Engelhardt, S., Wang, Y., Sadoshima, J., Vatner, S.F., and Vatner, D.E. 2007. Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor.J Clin Invest117:1335-1343.]

100. Takagi, H., Matsui, Y., Hirotani, S., Sakoda, H., Asano, T., and Sadoshima, J. 2007. AMPK mediates autophagy during myocardial ischemia in vivo.Autophagy3:405-407.

99. Takagi, H., Matsui, Y., and Sadoshima, J. 2007. The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart.Antioxid Redox Signal9:1373-1381.

98. Yan, L., Vatner, D.E., O'Connor, J.P., Ivessa, A., Ge, H., Chen, W., Hirotani, S., Ishikawa, Y., Sadoshima, J., and Vatner, S.F. 2007. Type 5 adenylyl cyclase disruption increases longevity and protects against stress.Cell130:247-258.

97. Zhai, P., Gao, S., Holle, E., Yu, X., Yatani, A., Wagner, T., and Sadoshima, J. 2007. Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases.J Biol Chem282:33181-33191.


96. Ago, T., and Sadoshima, J. 2006. GDF15, a cardioprotective TGF-beta superfamily protein.Circ Res98:294-297.

95. Ago, T., and Sadoshima, J. 2006. Thioredoxin and ventricular remodeling.J Mol Cell Cardiol41:762-773.

94. Ago, T., Yeh, I., Yamamoto, M., Schinke-Braun, M., Brown, J.A., Tian, B., and Sadoshima, J. 2006. Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart.Antioxid Redox Signal8:1635-1650.

93. Chen, I.Y., Lypowy, J., Pain, J., Sayed, D., Grinberg, S., Alcendor, R.R., Sadoshima, J., and Abdellatif, M. 2006. Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha.J Biol Chem281:19369-19377.

92. Depre, C., Wang, Q., Yan, L., Hedhli, N., Peter, P., Chen, L., Hong, C., Hittinger, L., Ghaleh, B., Sadoshima, J., Vatner, D.E., Vatner, S.F., and Madura, K. 2006. Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy.Circulation114:1821-1828.

91. Liu, J., Sadoshima, J., Zhai, P., Hong, C., Yang, G., Chen, W., Yan, L., Wang, Y., Vatner, S.F., and Vatner, D.E. 2006. Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition.J Mol Cell Cardiol41:680-688.

90. Nishizawa, T., Vatner, S.F., Hong, C., Shen, Y.T., Hardt, S.E., Robbins, J., Ishikawa, Y., Sadoshima, J., and Vatner, D.E. 2006. Overexpressed cardiac Gsalpha in rabbits.J Mol Cell Cardiol41:44-50.

89. Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J.T., Puigserver, P., Sadoshima, J., Deng, H., Pedrini, S., Gandy, S., Sauve, A.A., and Pasinetti, G.M. 2006. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.J Biol Chem281:21745-21754.

88. Sadoshima, J. 2006. Redox regulation of growth and death in cardiac myocytes.Antioxid Redox Signal8:1621-1624.

87. Usui, S., Yeh, I., Tian, B., and Sadoshima, J. 2006. Global changes in gene expression during cardiac hypertrophy: a new direction of cardiac signaling research.J Mol Cell Cardiol41:219-222.

86. Yan, L., Sadoshima, J., Vatner, D.E., and Vatner, S.F. 2006. Autophagy: a novel protective mechanism in chronic ischemia.Cell Cycle5:1175-1177.

85. Zebrowski, D.C., Alcendor, R.R., Kirshenbaum, L.A., and Sadoshima, J. 2006. Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity.J Mol Cell Cardiol40:605-618.

84. Zhai, P., Galeotti, J., Liu, J., Holle, E., Yu, X., Wagner, T., and Sadoshima, J. 2006. An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated cardiac hypertrophy.Circ Res99:528-536.

83. Zhai P, Galeotti J, Sadoshima J. 2006. Unconventional signaling mechanisms mediated by the angiotensin II type I receptor in cardiovascular cell types.High Blood Pressure and Cardiovasc Prevention: 13, 143-150.


82. Ding, B., Abe, J., Wei, H., Huang, Q., Walsh, R.A., Molina, C.A., Zhao, A., Sadoshima, J., Blaxall, B.C., Berk, B.C., and Yan, C. 2005. Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure.Circulation111:2469-2476.

81. Ding, B., Abe, J., Wei, H., Xu, H., Che, W., Aizawa, T., Liu, W., Molina, C.A., Sadoshima, J., Blaxall, B.C., Berk, B.C., and Yan, C. 2005. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis.Proc Natl Acad SciU S A

80. Hase, M., Depre, C., Vatner, S.F., and Sadoshima, J. 2005. H11 has dose-dependent and dual hypertrophic and proapoptotic functions in cardiac myocytes.Biochem J388:475-483.

79. Hirotani, S., and Sadoshima, J. 2005. Preconditioning effects of PKCdelta.J Mol Cell Cardiol39:719-721.

78. Morisco, C., Condorelli, G., Trimarco, V., Bellis, A., Marrone, C., Condorelli, G., Sadoshima, J., and Trimarco, B. 2005. Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes.Circ Res96:180-188.

77. Ono, H., Ichiki, T., Ohtsubo, H., Fukuyama, K., Imayama, I., Hashiguchi, Y., Sadoshima, J., and Sunagawa, K. 2005. Critical role of Mst1 in vascular remodeling after injury.Arterioscler Thromb Vasc Biol25:1871-1876.

76. Yan, L., Vatner, D.E., Kim, S.J., Ge, H., Masurekar, M., Massover, W.H., Yang, G., Matsui, Y., Sadoshima, J., and Vatner, S.F. 2005. Autophagy in chronically ischemic myocardium.Proc Natl Acad Sci U S A102:13807-13812.

75. Zhai, P., Yamamoto, M., Galeotti, J., Liu, J., Masurekar, M., Thaisz, J., Irie, K., Holle, E., Yu, X., Kupershmidt, S., Roden, D.M., Wagner, T., Yatani,A., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2005. Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.J Clin Invest115:3045-3056.


74. Alcendor, R.R., Kirshenbaum, L.A., Imai, S., Vatner, S.F., and Sadoshima, J. 2004. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes.Circ Res95:971-980.

73. Hardt, S.E., and Sadoshima, J. 2004. Negative regulators of cardiac hypertrophy.Cardiovasc Res63:500-509.

72. Hardt, S.E., Tomita, H., Katus, H.A., and Sadoshima, J. 2004. Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy.Circ Res94:926-935.

71. Karoor, V., Vatner, S.F., Takagi, G., Yang, G., Thaisz, J., Sadoshima, J., and Vatner, D.E. 2004. Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure.J Mol Cell Cardiol36:305-312.

70. Kawabe, J., Okumura, S., Lee, M.C., Sadoshima, J., and Ishikawa, Y. 2004. Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells.Am J Physiol Heart Circ Physiol286:H1845-1852.

69. Kim, T.G., Chen, J., Sadoshima, J., and Lee, Y. 2004. Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors.Mol Cell Biol24:10151-10160.

68. Matsui, Y., and Sadoshima, J. 2004. Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli: implication for cardiac fibrosis and hypertrophy.J Mol Cell Cardiol37:477-481.


67. Kim, S.J., Peppas, A., Hong, S.K., Yang, G., Huang, Y., Diaz, G., Sadoshima, J., Vatner, D.E., and Vatner, S.F. 2003. Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms.Circ Res92:1233-1239.

66. Kim, Y.K., Kim, S.J., Yatani, A., Huang, Y., Castelli, G., Vatner, D.E., Liu, J., Zhang, Q., Diaz, G., Zieba, R., Thaisz, J., Drusco, A., Croce, C., Sadoshima, J., Condorelli, G., and Vatner, S.F. 2003. Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt.J Biol Chem278:47622-47628.

65. Li, J., Yatani, A., Kim, S.J., Takagi, G., Irie, K., Zhang, Q., Karoor, V., Hong, C., Yang, G., Sadoshima, J., Depre, C., Vatner, D.E., West, M.J., and Vatner, S.F. 2003. Neurally-mediated increase in calcineurin activity regulates cardiac contractile function in absence of hypertrophy.Cardiovasc Res59:

64. Morisco, C., Sadoshima, J., Trimarco, B., Arora, R., Vatner, D.E., and Vatner, S.F. 2003. Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus.Am J Physiol Heart Circ Physiol284:H1043-1047.

63. Okumura, S., Kawabe, J., Yatani, A., Takagi, G., Lee, M.C., Hong, C., Liu, J., Takagi, I., Sadoshima, J., Vatner, D.E., Vatner, S.F., and Ishikawa, Y. 2003. Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation.Circ Res93: 364-371.

62. Okumura, S., Takagi, G., Kawabe, J., Yang, G., Lee, M.C., Hong, C., Liu, J., Vatner, D.E., Sadoshima, J., Vatner, S.F., and Ishikawa, Y. 2003. Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload.Proc Natl Acad Sci U S A100:9986-9990.

61. Seta, K., and Sadoshima, J. 2003. Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor.J Biol Chem278:9019-9026.

60. Tomita, H., Nazmy, M., Kajimoto, K., Yehia, G., Molina, C.A., and Sadoshima, J. 2003. Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation.Circ Res93:12-22.

59. Yamamoto, M., Yang, G., Hong, C., Liu, J., Holle, E., Yu, X., Wagner, T., Vatner, S.F., and Sadoshima, J. 2003. Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy.J Clin Invest112:1395-1406.

58. Yamamoto, S., Yang, G., Zablocki, D., Liu, J., Hong, C., Kim, S.J., Soler, S., Odashima, M., Thaisz, J., Yehia, G., Molina, C.A., Yatani, A., Vatner, D. E., Vatner, S.F., and Sadoshima, J. 2003. Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.J Clin Invest111:1463-1474.


57. Condorelli, G., Drusco, A., Stassi, G., Bellacosa, A., Roncarati, R., Iaccarino, G., Russo, M.A., Gu, Y., Dalton, N., Chung, C., Latronico, M.V., Napoli, C., Sadoshima, J., Croce, C.M., and Ross, J., Jr. 2002. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice.Proc Natl Acad Sci U S A99:12333-12338.

56. Depre, C., Hase, M., Gaussin, V., Zajac, A., Wang, L., Hittinger, L., Ghaleh, B., Yu, X., Kudej, R.K., Wagner, T., Sadoshima, J., and Vatner, S.F. 2002. H11 kinase is a novel mediator of myocardial hypertrophy in vivo.Circ Res91:1007-1014.

54. Hardt, S.E., and Sadoshima, J. 2002. Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development.Circ Res90: 1055-1063.

54. Sadoshima, J. 2002. Novel AT(1) receptor-independent functions of losartan.Circ Res90:754-756.

53. Sadoshima, J., Montagne, O., Wang, Q., Yang, G., Warden, J., Liu, J., Takagi, G., Karoor, V., Hong, C., Johnson, G.L., Vatner, D.E., and Vatner, S. F. 2002. The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy.J Clin Invest110:271-279.

52. Seta, K., Nanamori, M., Modrall, J.G., Neubig, R.R., and Sadoshima, J. 2002. AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs.J Biol Chem277:9268-9277.

51. Seta, K., and Sadoshima, J. 2002. What is the unique function of SAPK3/p38gamma in cardiac myocytes?J Mol Cell Cardiol34:597-600.


50. Modrall, J.G., Nanamori, M., Sadoshima, J., Barnhart, D.C., Stanley, J.C., and Neubig, R.R. 2001. ANG II type 1 receptor downregulation does not require receptor endocytosis or G protein coupling.Am J Physiol CellPhysiol 281:C801-809.

49. Morisco, C., Seta, K., Hardt, S.E., Lee, Y., Vatner, S.F., and Sadoshima, J. 2001. Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes.J Biol Chem276:28586-28597.

48. Morisco, C., Zebrowski, D.C., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2001. Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart.J Mol Cell Cardiol33:561-573.

47. Yamamoto, S., Seta, K., Morisco, C., Vatner, S.F., and Sadoshima, J. 2001. Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes.J Mol Cell Cardiol33:1829-1848.

46. Yang, G., Meguro, T., Hong, C., Asai, K., Takagi, G., Karoor, V.L., Sadoshima, J., Vatner, D.E., Bishop, S.P., and Vatner, S.F. 2001. Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be due to apoptosis and fibrosis.J Mol Cell Cardiol33:1505-1514.


45. Aoki, H., Richmond, M., Izumo, S., and Sadoshima, J. 2000. Specific role of the extracellular signal-regulated kinase pathway in angiotensin II- induced cardiac hypertrophy in vitro.Biochem J347 Pt 1:275-284.

44. Aoki, H., Sadoshima, J., and Izumo, S. 2000. Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro.Nat Med6:183-188.

43. Babu, G.J., Lalli, M.J., Sussman, M.A., Sadoshima, J., and Periasamy, M. 2000. Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy.J Mol Cell Cardiol32:1447-1457.

42. Morisco, C., Zebrowski, D., Condorelli, G., Tsichlis, P., Vatner, S.F., and Sadoshima, J. 2000. The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes.J Biol Chem275:14466-14475.

41. Sadoshima, J. 2000. Cytokine actions of angiotensin II.Circ Res86:1187-1189.


40. Malhotra, R., Sadoshima, J., Brosius, F.C., 3rd, and Izumo, S. 1999. Mechanical stretch and angiotensin II differentially upregulate the renin-angiotensin system in cardiac myocytes In vitro.Circ Res85:137-146.

39. Yamamoto, M., Okumura, S., Schwencke, C., Sadoshima, J., and Ishikawa, Y. 1999. High efficiency gene transfer by multiple transfection
protocol.Histochem J31:241-243.


38. Aoki, H., Izumo, S., and Sadoshima, J. 1998. Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation.Circ Res82:666-676.

37. Sadoshima, J. 1998. Versatility of the angiotensin II type 1 receptor.Circ Res82:1352-1355.


36. Sadoshima, J., Aoki, H., and Izumo, S. 1997. Angiotensin II and serum differentially regulate expression of cyclins, activity of cyclin-dependent kinases, and phosphorylation of retinoblastoma gene product in neonatal cardiac myocytes.Circ Res80:228-241.

35. Sadoshima, J., and Izumo, S. 1997. The cellular and molecular response of cardiac myocytes to mechanical stress.Annu Rev Physiol59:551-571.

34. Sadoshima, J., and Izumo, S. 1997. Tyrosine kinases mediation of c-fos expression by cell swelling in cardiac myocytes.Heart Vessels Suppl12:194-197.

33. Todisco, A., Takeuchi, Y., Yamada, J., Sadoshima, J.I., and Yamada, T. 1997. Molecular mechanisms for somatostatin inhibition of c-fos gene expression.Am J Physiol272:G721-726.


32. Jahn, L., Sadoshima, J., Greene, A., Parker, C., Morgan, K.G., and Izumo, S. 1996. Conditional differentiation of heart- and smooth muscle-derived cells transformed by a temperature-sensitive mutant of SV40 T antigen.J Cell Sci109 ( Pt 2):397-407.

31. Sadoshima, J., and Izumo, S. 1996. Autocrine secretion of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro.Contrib Nephrol118:214-221.

30. Sadoshima, J., and Izumo, S. 1996. The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes.Embo J15:775-787.

29. Sadoshima, J., Malhotra, R., and Izumo, S. 1996. The role of the cardiac renin-angiotensin system in load-induced cardiac hypertrophy.J Card Fail2:S1-6.

28. Sadoshima, J., Qiu, Z., Morgan, J.P., and Izumo, S. 1996. Tyrosine kinase activation is an immediate and essential step in hypotonic cell swelling-induced ERK activation and c-fos gene expression in cardiac myocytes.Embo J15:5535-5546.


27. Sadoshima, J., and Izumo, S. 1995. Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy.Circ Res77:1040-1052.

26. Sadoshima, J., Qiu, Z., Morgan, J.P., and Izumo, S. 1995. Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling.Circ Res76:1-15.

25. Schunkert, H., Sadoshima, J., Cornelius, T., Kagaya, Y., Weinberg, E.O., Izumo, S., Riegger, G., and Lorell, B.H. 1995. Angiotensin II-induced growth responses in isolated adult rat hearts. Evidence for load-independent induction of cardiac protein synthesis by angiotensin II.Circ Res76:489-497.


24. Jahn, L., Sadoshima, J., and Izumo, S. 1994. Cyclins and cyclin-dependent kinases are differentially regulated during terminal differentiation of C2C12 muscle cells.Exp Cell Res212:297-307.

23. Kai, H., Koyanagi, S., Hirooka, Y., Sugimachi, M., Sadoshima, J., Suzuki, S., and Takeshita, A. 1994. Right-to-left shunt across atrial septal defect related to tricuspid regurgitation: assessment by transesophageal Doppler echocardiography.Am Heart J127:578-584.


22. Sadoshima, J., and Izumo, S. 1993. Mechanotransduction in stretch-induced hypertrophy of cardiac myocytes.J Recept Res13:777-794.

21. Sadoshima, J., and Izumo, S. 1993. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.Embo J12:1681-1692.

20. Sadoshima, J., and Izumo, S. 1993. Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.Circ Res73:413-423.

19. Sadoshima, J., and Izumo, S. 1993. Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers.Circ Res73:424-438.

18. Sadoshima, J., Xu, Y., Slayter, H.S., and Izumo, S. 1993. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro.Cell75:977-984.


17. Sadoshima, J., Jahn, L., Takahashi, T., Kulik, T.J., and Izumo, S. 1992. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy.J Biol Chem267:10551-10560.

16. Sadoshima, J., Koyanagi, S., Sugimachi, M., Hirooka, Y., and Takeshita, A. 1992. Evaluation of the severity of mitral regurgitation by transesophageal Doppler flow echocardiography.Am Heart J123:1245-1251.

15. Sadoshima, J., Takahashi, T., Jahn, L., and Izumo, S. 1992. Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes.Proc Natl Acad Sci U S A89:9905-9909.


14. Lai, C.P., Koyanagi, S., Sadoshima, J., Takeshita, A., and Tokunaga, K. 1991. Transesophageal echocardiographic findings of quadricuspid aortic valve.Jpn Heart J32:731-734.

13. Sadoshima, J., and Akaike, N. 1991. Kinetic properties of the caffeine-induced transient outward current in bull-frog sympathetic neurones.J Physiol433:341-355.


12. Kuga, T., Sadoshima, J., Tomoike, H., Kanaide, H., Akaike, N., and Nakamura, M. 1990. Actions of Ca2+ antagonists on two types of Ca2+ channels in rat aorta smooth muscle cells in primary culture.Circ Res67:469-480.

11. Sadoshima, J., Oyama, Y., and Akaike, N. 1990. Inhibition of nicotinic acetylcholine response by atropine in frog isolated sympathetic neurons.Brain Res508:147-151.


10. Akaike, N., Kanaide, H., Kuga, T., Nakamura, M., Sadoshima, J., and Tomoike, H. 1989. Low-voltage-activated calcium current in rat aorta smooth muscle cells in primary culture.J Physiol416:141-160.

9. Akaike, N., and Sadoshima, J. 1989. Caffeine affects four different ionic currents in the bull-frog sympathetic neurone.J Physiol412:221-244.

8. Sadoshima, J., Akaike, N., Tomoike, H., Kanaide, H., and Nakamura, M. 1989. Voltage-dependent anion-selective channels in cultured smooth muscle cells of the rat aorta.Comp Biochem Physiol A Comp Physiol92:61-63.


7. Oyama, Y., Sadoshima, J., Tokutomi, N., and Akaike, N. 1988. Some properties of inhibitory action of lidocaine on the Ca2+ current of single isolated frog sensory neurons.Brain Res442:223-228.

6. Sadoshima, J., Akaike, N., Kanaide, H., and Nakamura, M. 1988. Cyclic AMP modulates Ca-activated K channel in cultured smooth muscle cells of rat aortas.Am J Physiol255:H754-759.

5. Sadoshima, J., Akaike, N., Tomoike, H., Kanaide, H., and Nakamura, M. 1988. Ca-activated K channel in cultured smooth muscle cells of rat aortic media.Am J Physiol255:H410-418.

4. Sadoshima, J., Tokutomi, N., and Akaike, N. 1988. Effects of neostigmine and physostigmine on the acetylcholine receptor-ionophore complex in frog isolated sympathetic neurones.Br J Pharmacol94:620-624.


3. Inoue, M., Sadoshima, J., and Akaike, N. 1987. Different actions of intracellular free calcium on resting and GABA-gated chloride conductances.Brain Res404:301-303.

2. Sadoshima, J., Nakashima, Y., Taira, Y., Koyanagi, S., Takeshita, A., Tanaka, K., and Nakamura, M. 1987. A case of primary dissecting aneurysm of the coronary artery.Jpn Heart J28:799-804.

1. Sadoshima, J., Taira, Y., Shimokawa, H., Koyanagi, S., Takeshita, A., and Nakamura, M. 1987. Two cases of dilated cardiomyopathy complicated by left ventricular aneurysm.Chest92:377-379.1