Selected Publications of Dr. Xie:

  1. Gonzalez JP, Ramachandran J, Xie LH, Contreras JE, Fraidenraich D. Selective connexin43 inhibition prevents isoproterenol-induced arrhythmias and lethality in muscular dystrophy mice. Scientific Reports. 2015;5 :13490
  2. Shanmugam M., Li D., Gao S., Fefelova N., Shah V., Voit A., Pachon R., Yehia G., Xie L.H., Babu G.J. Cardiac specific expression of threonine 5 to alanine mutant sarcolipin results in structural remodeling and diastolic dysfunction. PLoS One. 2015; 10:e0115822.
  3. Zhao Z., Babu G.J., Wen  H.,  Fefelova N., Gordan R., Sui X.,  Yan L., Vatner D.E., Vatner S.F., Xie L.H. Overexpression of Adenylyl Cyclase Type 5 (AC5) Confers a Proarrhythmic Substrate to the Heart. American Journal of Physiology- Heart Circ Physiology. 2015; 308:H240-9
  4. Zhao Z., Gordan R., Wen H., Fefelova N., Zang W.J., L.H. Xie. Modulation of intracellular Calcium waves and triggered activities by mitochondrial Ca flux in mouse cardiomyocytes. PLoS One 2013 8(11): e80574. doi:10.1371
  5. Xie LH, Doye AA, Conley E, Gwathmey JK. Sickle Cell Anemia: The Impact of Discovery, Politics, and Business. Journal of Health Care for the Poor and Underserved. 2013; 24: 147-158.
  6. Park M., Vatner S.F., Yan L., Gao S., Yoon G. S., Lee J. A., Xie L.H., Kitsis R.N., Vatner D. E. Caspase Inhibition Prevents Hypertrophy and Improves Cardiac Function with Chronic Pressure Overload. Basic Research in Cardioloy. 2013;108:324-,2013
  7. Matsushima S., Kuroda J., Ago T., Zhai P., Park J.Y., Xie L.H.,Tian B., Sadoshima J. Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy. Circulation Research 2013; 449 :133-42
  8. Ramachandran J., Schneider J.S., Crassous P.A., Zheng R., Gonzalez J.P., Xie L.H., Beuve A., Fraidenraich D., R. Peluffo D. Nitric Oxide Signaling Pathway in Duchenne Muscular Dystrophy Mice: Upregulation of L-arginine Transporters. Biochemical Journal. 2013; 449:133-42
  9. Zhao Z., Fang M., Xiao D., Liu M.. Fefelova N., Huang C., Zang W.J., Xie L.H. Potential Antiarrhythmic Effect of Methyl-3,4,5-Trimethoxycinnamic Acid, an Bioactive Substance from Roots of Polygalae Radix. Biological and Pharmaceutical Bulletin 2013;36(2):238-44
  10. Wang S.J., Xie L.H., Heng B., Liu Y.Q. Classification of potassium and chlorine ionic currents in retinal ganglion cell line (RGC-5) by whole-cell patch clamp. Visual Neuroscience 2012;29:275-82
  11. Zhao Z., Wen H., Fefelova N., Allen C., Guillaume N., Xiao D., Gwathmey J.K., Xie L.H. Docosahexaenoic Acid Reduces the Incidence of Early Afterdepolarizations caused by Oxidative Stress in Rabbit Ventricular Myocytes. Frontiers in Physiology 2012;3:252
  12. Zhao Z., Xie Y., Wen H., Xiao D., Allen C., Fefelova N., Dun W., Boyden P.A., Qu Z., Xie L.H. Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells. Cardiovascular Research 2012;95:308-16
  13. Xie L.H., Shanmugam M., Park J.Y., Zhao Z., Wen H., Tian B., Periasamy M., Babu G.J. Ablation of sarcolipin results in atrial remodeling. American Journal of Physiology-Cellular physiology 2012;302:C1762-71
  14. Zhao Z., Wen H., Fefelova N., Allen C., Baba, A., Matsuda, T., Xie L.H. Revisiting the Ionic Mechanisms of Early Afterdepolarizations in Cardiomyocytes: Predominant by Ca Waves or Ca Currents. American Journal of Physiology- Heart Circ Physiology 2012; 302:H1636-44,
  15. BaljinnyamE., Umemura M., DeLorenzo M.S., Xie L.H., Nowycky M., Iwatsubo M., Chen S., Goydos J. S., Iwatsubo K. G betagamma subunits inhibit Epac-induced melanoma cell migration. BMC Cancer11:256, 2011.
  16. Zhao Z., Fefelova N., Mayilvahanan S., Bishara P., Babu G., Xie L.H. Angiotensin II Induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling. Journal of Molecular and Cellular Cardiology 50(1):128-36, 2011.
  17. Peng L., Sun S., Xie L.H., Wicks S. M., Xie J.T. Ginsenoside Re: Pharmacological Effects of on Cardiovascular System. Cardiovascular Therapeutics 2011 in press (review)
  18. Shanmugam, M., Gao S., Hong C., Fefelova N., Nowycky M.C., Xie L.H., Periasamy M., Babu G. J. Ablation of Phospholamban and Sarcolipin Results in Cardiac Hypertrophy and Decreased Cardiac Contractility. Cardiovascular Research89:353-61, 2010.
  19. Baljinnyam E., De Lorenzo M.S., Xie L.H., Iwatsubo M., Chen S., Goydos J.S., Nowycky M.C., Iwatsubo K.. Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca2+-Dependent Mechanism. Cancer Research 70:5607-17, 2010.
  20. Sato D., Xie L.H., Nguyen T.P., Weiss J.N., Qu Z. Irregularly-Appearing Early Afterdepolarizations in Cardiac Myocytes: Random Fluctuations or Dynamical Chaos? Biophysical Journal 99:765-773, 2010.
  21. Morita N., Sovari A.A., Xie Y., Fishbein M.C., Mandel W.J., Garfinkel A., Lin S.F., Chen P.S., Xie L.H., Chen F., Qu Z., Weiss J.N., Karagueuzian H.S. Increased Susceptibility of Aged Hearts to Ventricular Fibrillation During Oxidative Stress. American Journal of Physiology-Heart Circ Physiol. 297:H1594-605, 2009.
  22. Xie L.H., Weiss J.N. Arrhythmogenic consequences of intracellular calcium waves. American Journal of Physiology-Heart Circ Physiol. 297:H997-H1002, 2009.
  23. Sato D. *, Xie L.H. *, Sovari A.A., Tran D.X., Morita N., Xie F., Karagueuzian H., Garfinkel A., Weiss J.N., Qu Z. Synchronization of Chaotic Early Afterdepolarizations in the Genesis of Cardiac Arrhythmias. Proceedings of the National Academy of Sciences, USA 106:2983-8 , 2009; (* co-first author)
  24. Xie L.H., Chen F., Karagueuzian H.S., Weiss J.N. Oxidative Stress-Induced Afterdepolarizations and Calmodulin Kinase II Signaling. Circulation Research 104(1):79-86, 2009. (commented in Nature Medicine 2010; 16: 648-9)
  25. Xie L.H. (correspondence author), John S.A., Ribalet B. and Weiss J.N. Phosphatidylinositol-4,5-bisphosphate (PIP2) Regulation of Strong Inward Rectifier Kir2.1 Channels: Multilevel Positive Cooperativity. Journal Physiology (London). 2008, 586; 1833-48. 2008.
  26. de Diego C., Pai R.K., Chen F.,. Xie L.H, De Leeuw J., Weiss J.N., Valderrábano M. Electrophysiological consequences of acute regional ischemia/reperfusion in neonatal rat ventricular myocyte monolayers. Circulation. 118:2330-7, 2008
  27. Xie L.H., Sato D., Garfinkel A., Qu Z, Weiss J. N. Intracellular Ca Alternans:Coordinated Regulation by Sarcoplasmic Reticulum Release, Uptake and Leak. Biophysical Journal 95 :3100-10, 2008.
  28. de Diego C., Pai R.K., Dave A.S., Lynch A., Thu M., Chen F., L.H. Xie, Weiss J.N., Valderrábano M. Spatially discordant alternans in cardiomyocyte monolayers. American Journal of Physiology-Heart Circ Physiol. 294: H1417-25, 2008.
  29. de Diego C., Chen F., Xie L.H., Dave A. S., Thu M., Weiss J.N., Valderrábano M. Cardiac alternans in embryonic mouse hearts. American Journal of Physiology-Heart Circ Physiol.294:H433-40,2008.
  30. Mahajan A., Sato D., Shiferaw Y., Baher A., Xie L.H., Peralta R., Olcese R., Garfinkel A., Qu Z., and Weiss J.N. Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics. Biophysical Journal 94: 411-23,2008.
  31. Mahajan A., Shiferaw Y., Sato D., Baher A., Olcese R., Xie L.H., Yang J., Karma A., Chen P.S., Garfinkel A., Qu Z., and Weiss J.. A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophysical Journal 94:392-410, 2008.
  32. Chen F., De Diego C., Xie L.H., Yang J.H., Klitzner T. S, Weiss J.N. Arrhythmias induced by metabolic inhibitors in mouse embryo hearts. American Journal of Physiology-Heart Circ Physiol.293(4):H2472-8,2007.
  33. Ramachandran S., Xie L.H., John S.A, Subramaniam S., Lal R.. Hemichannel initiates oxidative stress and smoking-induced apoptosis. PLoS One 2:e712, 2007.
  34. Ruan H., Mitchell S., Vainoriene M., Lou Q., Xie L.H., Ren S., Goldhaber J. I., Wang Y. A Gαi Mediated Mechanism in Cardiac Eletrophysiological Remodeling and Arrhythmia in Hypertrophic Cardiomyopathy. Circulation Research 116(6):596-605, 2007.
  35. Xie L.H. (correspondence author), John S.A., Ribalet B., and Weiss J.N. Activation of inwardly rectifying potassium (Kir) channels by Phosphatidylinosital-4,5-bisphosphate (PIP2): Interaction with other regulatory ligands. (review) Prog Biophys Mol Biol. 94:320-335, 2007.
  36. Ribalet B., John S. A., Xie L.H., and Weiss J. N. ATP-sensitive K channels: Regulation of bursting by the sulfonyurea receptor, PIP2 and regions of Kir6.2. Journal Physiology (London). 571: 303-17, 2006.
  37. Feng J.M., Hu Y.K., Xie L.H., Colwell C.S., Shao, X.M. Sun X.P., Chen B., Tang H., Campagnoni A.T.. Golli protein negatively regulates store depletion-induced calcium influx in T cells. Immunity. 24:717-27, 2006.
  38. Xie L.H., John S., Ribalet B., Weiss J. N. Long polyamines act as co-factors in PIP2 activation of inward rectifier potassium (Kir2.1) channels. Journal of General Physiology.126:541-549, 2005 (Featured in the cover figure).
  39. Goldhaber J.I., Xie L.H., Duong T., Motter C., Khuu K., and Weiss J. N. Action potential duration restitution and alternans in rabbit ventricular myocytes: The key role of intracellular calcium cycling. Circulation Research. 96:459-66, 2005.
  40. Ribalet B., John S.A., Xie L.H. and Weiss J.N. Regulation of the ATP-sensitive K channel Kir6.2 by ATP and PIP2. (review) Journal of Molecular and Cellular Cardiology 39:71-77,2005
  41. John S.A., Xie L.H., Weiss J.N. Mechanism of inward rectification in Kir channels (letter to the editor). Journal of General Physiology. 123:623-5, 2004.
  42. Xie L.H. (correspondence author), John S., Ribalet B., Weiss J. N. Regulation of Gating by Negative Charges in the Cytoplasmic Pore in the Kir2.1 Channel. Journal of Physiology (London). 561:159-68, 2004.
  43. John S.A., Weiss J.N., Xie L.H., Ribalet B. Molecular mechanism for Kir6.2 ATP-dependent closure. Journal of Physiology (London). 552: 23-34, 2003.
  44. Xie L.H., John S., Weiss J. N. Inward rectification by polyamines in Kir2.1 channels: synergy between blocking components. Journal of Physiology (London). 550:67-82, 2003.
  45. Xie L.H., John S., Weiss J. N. Spermine block of the strong inward rectifier potassium channel Kir2.1: Dual roles of surface charge screening and pore block. Journal of General Physiology. 120:53-66, 2002.
  46. Haruna T., Yoshida H., Nakamura T.Y., Xie L.H., Otani H., Ninomiya T., Takano M., Coetzee W.A., Horie M.. a1-Adrenoceptor-mediated breakdown of phosphatidylinosital-4,5-bisphosphate inhibits Pinacidil-activated KATP currents in rat ventricular myocytes. CirculationResearch 91: 232-239, 2002.
  47. Makita T., Horie M., Xie L.H., Okada Y., Sasayama S. Agonist-independent modulation of L-type Ca currents by basal Gs protein activities in single guinea pig ventricular myocytes. Heartand Vessels. 15:233-9, 2000.
  48. Kono Y., Horie M., Takano M., Otani H., Xie L.H., Akao M., Tsuji K., Sasayama S. The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A. Pflügers Arch-European Journal of Physiology440:692-8, 2000.
  49. Xie L.H., Horie M., Takano M. Phospholipase C-linked receptors regulate the ATP-sensitive potassium channel by means of phosphatidylinositol 4,5-bisphosphate metabolism. Proceedings of the National Academy of Sciences, USA 96: 15292-7, 1999.
  50. Ishii T.M., Takano M., Xie L.H., Noma A., Ohmori H. Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node. Journal ofBiological Chemistry 274: 12835-9, 1999
  51. Xie L.H., Takano M., Kakei M., Noma A. Wortmannin, an inhibitor of phosphatidylinositol kinase, blocks the MgATP-dependent recovery of Kir6.2-SUR2A channel. Journal of Physiology (London) 514: 655-665, 1999.
  52. Takano M., Xie L.H., Otano H., Hoire M.. Cytoplasmic terminus domains of Kir6.x confer different nucleotide–dependent gating on the ATP-sensitive K+ channel. Journal of Physiology (London) 512: 395-406, 1998.
  53. Xie L.H. (correspondence author), Takano M., Noma A. The inhibitory effect of propranolol on ATP-sensitive potassium channels in neonatal rat heart. British Journal of Pharmacology 123: 599-604, 1998.
  54. L.H. Xie, Takano M., Noma A. Development of inwardly rectifying K+ channel family in rat ventricular myocytes. American Journal of Physiology 272: H1741-50, 1997.
  55. Obayashi K., Horie M., Xie L.H., Tsuchiya K., Kubota A., Ishida H., Sasayama S. Angiotensin II inhibits protein kinase A-dependent chloride conductance in heart via pertussis toxin-sensitive G proteins. Circulation 95: 197-204,1997.
  56. Takano M., Ishii T., Xie L.H. Cloning and functional expression of the rat brain KIR6.2 channel. Japanese Journal of Physiology 46: 491-5, 1996.
  57. Horie M., Obayashi K., Xie L.H.,. James A.F, Sasayama S. Hormonal regulation of cardiac cystic fibrosis transmembrane conductance regulator chloride channels. Japanese Heart Journal 37: 661-71, 1996.
  58. Horie M., Watanuki M., Tsuchiya K., Hayashi S. Obayashi K., Xie L.H., Yuzuki Y., Takahashi A., Sasayama S. Autonomic regulation of cardiac ATP-sensitive K+ channel activation. In Recent Progress in Electropharmacology of the Heart 1996. Eds. J. Toyama, M. Hiraoka, and I. Kodama. pp73-82. Florida: CRC Press Inc.
  59. Xie L.H., Horie M., James A.F., Watanuki M., Sasayama S. Endothelin-1 inhibits L-type Ca currents enhanced by isoproterenol in guinea-pig ventricular myocytes. Pflügers Arch-European Journal of Physiology 431: 533-9, 1996.
  60. Horie M., Makita T., Oe H., Xie L.H., and Sasayama S. Involvement of pertussis toxin-sensitive G-proteins in the mechanism of postvagal potentiation of cardiac calcium and chloride currents. Heart and Vessels 58-60, 1995.
  61. James A.F., Xie L.H., Fujitani Y., Hayashi S., and Horie M. ET-A receptors mediate inhibition of the cardiac PKA-dependent Cl- current via a pertussis toxin-sensitive mechanism. Heart and Vessels. 83-85, 1995.
  62. Li J.Y., Xie L.H., Li Q., Guo S.D. Effects of resibufogenin and ouabain on transmembrane action potential and extracellular potassium ion activity during triggered activity in guinea pig ventricular muscle. Acta Biophysics Sinica 11: 37-42, 1995.
  63. James A.F., Xie L.H., Fujitani Y., Hayashi S., Horie M.Inhibition of the cardiac protein kinase A-dependent chloride conductance by endothelin-1. Nature 370: 297-300,1994.
  64. Oe H., Xie L.H., Horie M. Inhibitory pathway of cardiac PKA-dependent Cl- conductance via pertussis toxin-sensitive G proteins. Japanese Journal of Physiology.44:S219-26, 1994
  65. Jin B.L., Xie L.H., Chen D.C., Li C.L., Xie J.T. The electrophysiological effects of alcoholized rhubarb solution in feline heart in vivo. Methods and Findings in Experimental and Clinical Pharmacology 15: 23-9, 1993.
  66. Xie L.H., Xie J.T. Effects of tetrodoxin and verapamil on triggered activities induced by cesium chloride in cat heart in vivo. Acta Pharmacologica Sinica13: 38-41,1992. (in Chinese)
  67. Xie L.H., Xie J.T. Electrophysiological studies of after-depolarizations and arrhythmias in the heart in vivo. Acta Physiologica Sinica43: 257-64, 1991.
  68. Xie J.T., Xie L.H. Can the MAP technique be applied to study triggered activities of the heart? Intracellular evidence in vivo. Methods and Findings in Experimental and Clinical Pharmacology 12: 419-24, 1990.
  69. Xie J.T., Xie L.H., Li C.L, Liang N., Feng X. Effects of resibufogenin on monophasic action potential and contractile force of rabbit heart in situ. Acta Pharmacologica Sinica 9: 536-8, 1988.
  70. Xie J.T., Xie L.H., Li C.L., Liang N., Feng X. Resibufogenin-induced delayed afterdepolarization in rabbit heart in situ. Methods and Findings in Experimental and Clinical Pharmacology 10: 475-6, 1988