Sonia M. de Toledo

sonia

November 2004

OFFICE ADDRESS:

Department of Radiology
Division of Radiation Research
M.S.B. F-453
University of Medicine & Dentistry of NJ
Newark , NJ 07103
973-972-3412

EDUCATION:

Universidade de Sao Paulo (USP), Brazil
Ph.D. Biochemistry, (1981)
Universidade de Sao Paulo (USP), Brazil
B.Sc. Pharmaceutical Sciences and Biochemistry, (1975)

UNIVERSITY APPOINTMENTS:

Adjunct Assistant Professor, 2000-
Dept. of Radiology UMDNJ-NewJersey Medical School
Newark , NJ USA

Research Associate, 1986-1988
Dept. of Physiology, Faculty of Medicine
University of Manitoba , Winnipeg , Canada .

Assistant Professor, 1981-1983.
Instituto de Quimica,
Universidade Estadual de Campinas (UNICAMP)
Campinas , Brazil .

Instructor, 1977-1981.
Instituto de Quimica, UNICAMP
Campinas , Brazil .

OTHER PROFESSIONAL APPOINTMENTS

Research Scientist, 1990 -1997.
Radiation Biology Branch
Atomic Energy of Canada Ltd.
Chalk River , ON , Canada .

Research Fellow, 1989 - 1990.
Biomedical Physics Dept.
King Faisal Specialist Hospital
Riyadh , Saudi Arabia .

Research Scientist, 1988 - 1989.
Radiation Biology Branch
Atomic Energy of Canada Ltd.
Chalk River , ON ,  Canada .

ARTICLES:

  1. Venkatachalam P., de Toledo S. M. and Azzam E. I. (2004) Flavin Containing Oxidases Regulate Progression from G1 to S-Phase of the Cell Cycle in Normal Human Diploid Fibroblasts. Radiation Physics and Chemistry (In Press).
  2. Prasad V.S.V. Neti, Sonia M. de Toledo, Venkatachalam P., Edouard I. Azzam, and Roger W. Howell (2004) A Multi-Port Low-Fluence Alpha-Particle Irradiator for Radiobiological Applications: Fabrication, Testing, and Benchmark Radiobiological Studies. Radiat. Res . 161 , 732-738.
  3. Azzam, E. I. , Sonia, M. de Toledo and John B. Little (2004) Stress signaling from Irradiated to non-Irradiated Cells. Current Cancer Drug Targets 4 , 53-63.
  4. Azzam, E. I., Sonia M. de Toledo and John B. Little (2003) Gap-Junctions, Oxidative Metabolism and the Ionizing Radiation Induced Bystander Effect. Oncogene 22 , 7050-7057.
  5. Azzam, E. I., Sonia M. de Toledo and John B. Little (2003) Expression of CONNEXIN43 Is Highly Sensitive to Ionizing Radiation and other Environmental Stresses. Cancer Res . 63 , 7128-7135.
  6. Little J. B., Nagasawa H., de Toledo S. M. and Azzam E.I. (2002) Transmission of damage signals from irradiated to non-irradiated cells. International Congress Series 1236 , 229-235.
  7. Edouard I. Azzam, Sonia M. de Toledo and John B. Little (2003) Gap-Junctions, Oxidative Metabolism and the Ionizing Radiation Induced Bystander Effect.  Oncogene (accepted).
  8. Edouard I. Azzam and John B. Little (2003) The Radiation Induced Bystander Effect: Evidence and Significance.  Human and Experimental Toxicology (accepted).
  9. Edouard I. Azzam, Sonia M. de Toledo and John B. Little (2003) Expression of CONNEXIN43 Is Highly Sensitive to Ionizing Radiation and other Environmental Stresses.  Cancer Res.  (accepted).
  10. Edouard I. Azzam, Sonia, M. de Toledo and John B. Little (2003) Stress signaling from Irradiated to non-Irradiated Cells. Current Cancer Drug Targets (accepted).
  11. Sonia M. de Toledo, Edouard I. Azzam, Prasad V.S.V. Neti, and Roger W. Howell (2002) A Multi-Port Low-Fluence Alpha-Particle Irradiator for Radiobiological Applications: Construction, Testing, and Preliminary Radiobiological Studies. Radiat. Res. (submitted)
  12. Little J.B., Azzam E.I., de Toledo S.M., Nagasawa H. Bystander effects: intercellular transmission of radiation damage signals.  Radiat Prot Dosimetry. 2002; 99 (1-4):159-62.
  13. Azzam E. I, de Toledo S. M., Spitz D.R. and Little J.B. (2002) Oxidative Metabolism Modulates Signal Transduction and Micronucleus Formation in Bystander Cells from a-Particle-Irradiated Normal Human Fibroblast Cultures. Cancer Res. 62 , 5436-5442.
  14. Azzam E.I., de Toledo S.M. and Little J.B. (2001) Direct Evidence for the Participation of Gap-Junction Mediated Intercellular Communication in the Transmission of Damage Signals from a-Particle Irradiated to Non-irradiated Cells.  Proc..Natl. Acad. Sci USA . 98 , 473-478.
  15. de Toledo S.M., Azzam E.I., Dahlberg W.K., Gooding T.B. and Little J.B. (2000) ATM complexes with MDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation.  Oncogene , 19 , 6185-6193.
  16. Azzam E.I., de Toledo S.M. and Little J.B. (2000) High and low fluences of a-particles induce a G1 checkpoint in human diploid fibroblasts. Cancer Res ., 60 , 2623-2631.
  17. de Toledo SM, Azzam EI, Laffrenier S, Keng P and Little JB. (1998) "Regulation of the genes CDC2, cyclin A, Cyclin B, topoisomerase IIa  and RAD51 in irradiated normal human fibroblasts is dependent on p53/p21 Waf1 ".  Cell Growth Differ . 9 , 887-897.
  18. Azzam EI, de Toledo SM, Gooding TB and Little JB. (1998) "Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of a-particles".  Radiat. Res. , 150 , 497-504.
  19. Azzam EI, de Toledo SM, Pykett MJ, Nagasawa H and Little JB. (1997)  " CDC2 is down-regulated by ionizing radiation in a p53-dependent manner ".  Cell Growth Differ . 8, 1161-1169.
  20. Azzam EI, de Toledo SM, Raaphorst GP and Mitchel REJ. (1996) "Low dose ionizing radiation decreases the frequency of spontaneous transformation in C3H 10T2 cells".  Rad.Res . 146 , 369-373.
  21. de Toledo SM, Azzam EI, Gasmann MK and Mitchell REJ. (1995) "The use of semi-quantitative reverse transcription-polymerase chain reaction analysis to study gene expression in normal skin fibroblasts following low dose rate irradiation".   Int. J. Radiat. Biol . 67 , 135-143.
  22. Azzam EI, de Toledo SM, Raaphorst GP and Mitchell REJ. (1994) "Reactions d'adaptation au rayonnement ionisant des cellules fibroblastes de peau humaine. Augmentation de la capacite de reparation de l'ADN et variation de l'expression des genes".   J. de Chimie Physique et de Physico-Chimie Biologique 91 , 931-936.
  23. Azzam EI, de Toledo SM, Raaphorst GP and Mitchell REJ. (1992) "Radiation -induced radioresistance in a normal human skin fibroblast cell line". p 291-294.  In: Low dose irradiation and biological defense mechanisms  (Editors T Sugahara, L A Sagan and T Aoyama ) Elsevier Science Publishers. The Netherlands.
  24. Berczi I, Nagy E, de Toledo SM, Matusik RJ and Friesen HG. (1991) "Pituitary hormones regulate c-myc and DNA synthesis in lymphoid tissue".  J. Immunology 146 , 2201-2206.
  25. de Toledo SM, Murphy LJ, Hatton TH and Friesen HG. (1987) "Regulation of 70-kilodalton heat-shock-like messenger ribonucleic acid in vitro and in vivo by prolactin ".   Molec. Endocrinol . 1 (6), 430.
  26. de Toledo SM, Duran N and Singh H. (1983) "Inactivation of Escherichia coli ribosomes by the bioenergized system: malonaldehyde/horseradish peroxidase".  Photobiochem. Photobiophys . 5 , 237.
  27. Duran N, Haun NM, de Toledo SM, Cilento G and Silva E. (1983) "Binding of riboflavin to lysozyme by peroxidase generated acetone".  Photochem. Photobiol . 37 , (2), 247-250.
  28. de Mello MP, de Toledo SM, Aoyama H, Sackar HR, Cilento G and Duran N. (1982) "Peroxidase-generated triplet indole-3-aldehyde adds to uridine bases and excites the 4-thiouridine group on tRNA-Phe ".  Photochem. Photobiol . 36 , 21-24.
  29. Glover DM, Zaha A, Stocker AJ, Santelli RV, Pueyo MT, de Toledo SM and Lara FJS. (1982)"Gene amplification in Rhynchosciara salivary gland chromosomes".  Proc. Natl. Acad. Sci. USA 78 , 2947.
  30. de Toledo SM, Zaha A and Duran N. (1982) "DNA strand scission in E.coli by electronically excited state molecules generated by enzymatic systems".  Biochem. Biophys. Res. Commun . 104 , 990.
  31. de Mello MP, de Toledo SM and Duran N. (1981) "Photo and Bioenergized cycloaddition of indole-3-aldehyde to uridine".  Acta. Sud. Amer. Quim . ( Chile ), 1 , 135.
  32. de Mello MP, de Toledo SM, Haun NM , Cilento G and Duran N. (1980) "Excited Indole-3-aldehyde from the the peroxidase catalized aerobic oxidation of indole-3-acetic acid reaction with energy transfer to tRNA".  Biochemistry, 19 , 5270.
  33. Innocentini LH, de Toledo SM and Duran N. (1980) "Oxidation of glutathione by peroxidase, hydrogen peroxide detection by a bioenergized method".   An. Acad. Bras. Cienc . 52 , 691.
  34. de Toledo SM, Haun NM , Bechara EJH and Duran N. (1980) "Hydrogen peroxide and peroxidase detection by a bioenergized method".  Anal. Biochem . 105 , 36
  35. de Toledo SM and Lara FJS. (1978) "Translation of messages transcribed from the DNA puffs of Rhynchosciara ".  Biochem. Biophys. Res. Commun . 85 , 160.