Clinical Trials

Cardiology Clinical Trials

CURRENT CARDIOLOGY CLINICAL TRIALS

 


INDUSTRY SPONSORED STUDIES:


  1. RT-01-HF-REF: A Randomized, Phase 3, Placebo-Controlled, Double-Blind, Multicenter Trial of a One-time Intracoronary Administration of Human Adenovirus 5 encoding Human Adenylyl Cyclase Type 6 (RT-100) Gene Transfer for Patients with Heart Failure with Reduced Left Ventricular Ejection Fraction

Sponsor: Renova Therapeutics

Principal Investigator: Marc Klapholz, MD

 

  1. GRAHF-2: Genomic Analysis of Enhanced Response to Heart Failure Therapy in African Americans

Sponsor: NHLBI- Uni of Pittsburgh

Principal Investigator: Pallavi Solanki, MD

 

  1. AC-055-403: REPAIR STUDY: A prospective, multicenter, single-arm, open-label, Phase 4 study to evaluate the effects of macitentan on Right vEntricular remodeling in Pulmonary ArterIal hypeRtension assessed by cardiac magnetic resonance imaging)

Sponsor: Actelion

Principal Investigator: Alfonso Waller, MD

 

  1. ADMIRE-ICD: AdreView™ Myocardial Imaging for Risk Evaluation – A multicentre trial to guide ICD implantation in NYHA class II & III heart failure patients with 30%≤LVEF≤35%.

Sponsor: GE Healthcare

Principal Investigator: Alfonso Waller, MD

 

  1. BEAT- LUNG PAH: A multicenter, double-blind, randomized, placebo-controlled, Phase 3 study to assess the efficacy and safety of oral BPS-314d-MR added-on to treprostinil, inhaled (Tyvaso®) in subjects with pulmonary arterial hypertension

Sponsor: Lung LLC

Principal Investigator: Marc Klapholz, MD

 

  1. RESPOND CRT: To assess the safety and effectiveness of the automatic atrioventricular (AV) delay and interventricular (VV) delay optimization algorithm used in the PARADYM RF SONR Cardiac Resynchronization Therapy with Defibrillation (CRT-D) device (Model 9770) in combination with the SonRtip Lead, which includes a SonR sensor in the tip of the atrial pacing lead, and compatible programming software.

Sponsor: Sorin Group

Principal Investigator: Victor Mazza, MD

 

 

 


INVESTIGATOR INITIATED CLINICAL TRIALS:


  1. ST-Elevation Analysis Using Wireless Technology: Achieving the Golden Hour in Acute Myocardial Infarction- evaluating the efficacy of field based wireless ECG transmission in the treatment of STEMI. And their impact across gender and racial differences

    Principal Investigator: Marc Klapholz, MD

 

  1. Retrospective evaluation of cardiovascular disease in patients with HIV infection at NJMS University Hospital

Principal Investigator: Marc Klapholz, MD

 

  1. Defining The Cardiovascular Sequelae In The Pre & Post Liver Transplant Patients

Principal Investigator: Marc Klapholz, MD

 

  1. GraftMaster® RX Coronary Stent Graft System

Sponsor: Dept Funded

Principal Investigator: Marc Klapholz, MD

 

  1. Association Of Specific Protein Markers And Dilated Cardiomyopathy In African Americans

Principal Investigator: Marc Klapholz, MD

 

  1. Comparison of Left Ventricular Mass in Normal and Low Ejection Fraction Heart Failure

Principal Investigator: Marc Klapholz, MD

 

  1. Association of Early Repolarization with Cardiac Arrest following Acute Pulmonary Embolism

Principal Investigator: Marc Klapholz, MD

 

  1. Stress-induced cardiomyopathy

Principal Investigator: Pallavi Solanki, MD

 

  1. The Effects of High Power Potassium-Titanyl-Phosphate Laser Photoselective Vaporization Prostatectomy on Pacemakers and Implantable Cardioverter Defibrillators

Principal Investigator: Victor Mazza, MD

 

  1. The Effects of Extracorporeal Shockwave Lithotripsy on Pacemakers and Implantable Cardioverter Defibrillators

Principal Investigator: Victor Mazza, MD

 

  1. Evaluation of the of the association between Gender and Interventricular Mechanical Delay in a cohort of patients that are candidates for CRT Implantation

Sponsor: Dept Funded

Principal Investigator: Victor Mazza, MD

 

  1. Defining the cardiovascular sequelae in patients with sarcoidosis

Principal Investigator: Alfonso Waller, MD

 

  1. The diagnostic accuracy of M-Mode in differentiating intra-cardiac from extra-cardiac shunting during agitated saline bubble-enhanced echocardiography.

Principal Investigator: Alfonso Waller, MD

 

  1. Safety of Transesophageal Echocardiogram with patients with esophageal and gastric varices.

Principal Investigator: Alfonso Waller, MD