Department of Cell Biology & Molecular Medicine
Diego Fraidenraich, Ph.D.
Disease rescue by pluripotent stem cells.
nNOS and connexin-43 roles in Duchenne Muscular Dystrophy-cardiomyopathy
Epimorphic effects of pluripotent stem cells
Ph.D., 1994, INGEBI, University of Buenos Aires
Areas of Interest
Stem cell disease correction in mice
One main focus of my lab is to design paradigms for embryonic stem (ES) and induced pluripotent stem (iPS) cell based repair of
cardiac and skeletal muscle defects using mouse models of human disease (thin myocardial syndrome, cardiomyopathy, muscular
dystrophy). Another focus is to study paracrine non-myocardial factors in Id KO embryos/mice, a model of congenital heart disease
and adult fibrotic cardiomyopathy. The ultimate goal is to identify cardiotrophic and myotrophic factors with rescue potential.
We also produce human iPS cell - derived cardiomyocytes and other cell types, to model disease in the dish.
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