Department of Medicine
William C. Gause, Ph.D.
Metazoan parasites have coevolved with vertebrates over hundreds of millions of years, shaping the activation and function of the immune response including the development of potent immune regulatory pathways and enhanced immune cell-mediated wound healing effects. Understanding the molecular signaling events that trigger this type of immune response can provide insights into new approaches to regulate harmful inflammation and is an important area of Dr. Gause’s research. Research led by Dr. Gause also includes mining the products produced by these parasites for the development of novel therapies to control harmful inflammation and promote tissue repair.
Ph.D., 1986, Cornell University
|1. Lui Z, Liu Q, Pesce J, Anthony RM, Lamb E, Related Articles, Whitmire J, Hamed H, Morimoto M, Urban Requirements for the development of IL-4-producing T cells during intestinal nematode infections: what it takes to make a Th2 cell in vivo. Immunol Rev. 2004 Oct;201:57-74. PMID: 15361233 [PubMed - in process]|
|2. Liu Q, Arseculeratne C, Liu Z, Whitmire J, Grusby MJ, Finkelman FD, Darling TN, Cheever AW, Swearengen J, Urban JF, Gause WC. Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease. Infect Immun. 2004 Jul;72(7):3706-15. PMID: 15213110 [PubMed - indexed for MEDLINE]|
|3. Madden KB, Yeung KA, Zhao A, Gause WC, Finkelman FD, Katona IM, Urban JF Jr, Shea-Donohue T. Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function. J Immunol. 2004 May 1;172(9):5616-21. PMID: 15100305 [PubMed - indexed for MEDLINE]|
|4. Morimoto M, Morimoto M, Whitmire J, Xiao S, Anthony RM, Mirakami H, Star RA, Urban JF Jr, Gause WC. Peripheral CD4 T cells rapidly accumulate at the host: parasite interface during an inflammatory Th2 memory response. J Immunol. 2004 Feb 15;172(4):2424-30. PMID: 14764713 [PubMed - indexed for MEDLINE]|
|5. Zhao A, McDermott J, Urban JF Jr, Gause W, Madden KB, Yeung KA, Morris SC, Finkelman FD, Shea-Donohue T. Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves. J Immunol. 2003 Jul 15;171(2):948-54. PMID: 12847266 [PubMed - indexed for MEDLINE]|