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Department of Pharmacology, Physiology & Neuroscience

Christine M. Rohowsky-Kochan, Ph.D.

 

Medical Science Building (MSB)
185 South Orange Avenue Room H-596
Newark, NJ 07101
Phone: (973) 972-7394
Fax: (973) 972-7950

Biography

Education

Ph.D., 1983, Columbia University College of Physicians and Surgeons

 

 

Publications

Relevant Publications:

Magid-Bernstein J and Rohowsky-Kochan C. Human CD39+ Treg Cells Express Th17-Associated Surface Markers and Suppress IL-17 via a Stat3-Dependent Mechanism. J Interferon Cytokine Res. 37:153-164, 2017 doi: 10.1089/jir.2016.0071. Epub 2017 Feb 24.
Hao, L, Sheng, Z, Potian, J, Deak, A, Rohowsky-Kochan C. and Routh VH. Lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF03B1) blunt the response of Neuropeptide Y/Agouti-related peptide (NPY/AgRP) glucose inhibited (GI) neurons to decreased glucose. Brain Res. 2016 Jul 26. pii: S0006-8993(16)30517-0. doi: 10.1016/j.brainres.2016.07.035. [Epub ahead of print].
Magid-Bernstein J, Mahajan, K, Lincoln, J, Ming X and Rohowsky-Kochan C. Case Report: Cytokine and CD4+T cell profiles of monozygotic twins with autism and divergent co-morbidities and drug treatment. J of Child Neurology 30:386-390, 2015.
Joshi S, Pantalena LC, Liu XK, Gaffen SL, Liu H, Rohowsky-Kochan C, Ichiyama K, Yoshimura A, Steinman L, Christakos S, Youssef S. 1,25-Dihydroxyvitamin D3 Ameliorates Th17 Autoimmunity Via Transcriptional Modulation of IL-17A. Mol Cell Biol. 31:3653-3669, 2011.
Liu, H. and C. Rohowsky-Kochan. Interleukin-27-mediated suppression of human Th17 cells is associated with activation of STAT1 and suppressor of cytokine signaling protein 1. J Interferon Cytokine Res. 31:459-69, 2011.
Wang, J. Z. Lu, H-J. Gabius, C. Rohowsky-Kochan, R. Ledeen and G. Wu. Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation. Possible role in suppressing experimental autoimmune encephalomyelitis. . J. Immunol.182:4036- 4045, 2009.
Liu H, and C. Rohowsky-Kochan. Regulation of interleukin-17 in human CCR6+ effector memory T cells. J Immunol. 180:7948-7957, 2008.
Xie X, G. Wu, ZH. Lu, C. Rohowsky-Kochan, RW. Ledeen. Presence of sodium-calcium exchanger/GM1 complex in the nuclear envelope of non-neural cells: nature of exchanger-GM1 interaction. Neurochem Res. 29:2135-46, 2004.
Vitale, E., S. Cook, R. Sun, C. Specchia. K. Subramanian, M. Rocchi, D. Nathanson, M. Schwalb, M. Devoto and C. Rohowsky-Kochan. Linkage analysis conditional on HLA status in a large North American pedigree supports the presence of a multiple sclerosis susceptibility locus on chromosome 12p12. Human Molecular Genetics, 11: 295-300, 2002.
Rohowsky-Kochan, C., D. Molinaro and S. D. Cook. Cytokine secretion profiles of myelin basic protein-specific T cells in multiple sclerosis. Multiple Sclerosis. 6:69-77, 2000.

 

Current Research

Research in the laboratory focuses on the mechanisms that promote the differentiation of T
lymphocyte subsets and the mechanisms that regulate the immunological responses of T cells. We
are interested in strategies to manipulate these responses in clinically relevant areas such as
autoimmunity with an emphasis on neurological diseases such as multiple sclerosis and autism.
Recent studies have focused on studying the differentiation and regulation of human Th17 cells
and the cells regulating pathogenic Th17 responses as this subset may play a role in the
pathogenesis of multiple sclerosis and autism.



 

 

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