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[Home] [Cytokines] [Description] [Features & Philosophy] [Comparison] |
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[Class I] [Class II] [What is a Chemokine] [Chemokine Receptor Family] |
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COMPARISON OF HORMONES & CYTOKINES Because cytokines share many properties with hormones and growth factors, the distinction between these three classes of mediators is becoming blurred. For example, growth hormone is considered by many to be a cytokine because the growth hormone receptor is similar to Class I cytokine receptors. Any classification of cytokines represents a somewhat arbitrary arrangement on the part of the individual(s) doing the grouping to some extent. Abbas et al group the most common cytokines on the basis of their general properties. Cytokines that mediate and regulate innate immunity Type I interferons Tumor necrosis factor-a Interleukins 1, 6, 10, 12, and 15 Chemokines Cytokines that mediate and regulate specific immunity Interleukins 2, 4, 5, 13, 16, and 17 Interferon-g TGF-ß Lymphotoxin Cytokines that stimulate hematopoiesis c-kit ligand Interleukins 3, 7, 9, 11 Colony stimulating factors An encyclopedic web site of the cytokines may be found at: www.copewithcytokines.de Another way is to group them according to the sequence homology of the receptors to which they bind. Receptors for the various cytokines belong to one of four or five (depends on what you read) families of receptor proteins: Immunoglobulin superfamily Cytokine receptor family - Class I Cytokine receptor family - Class II TNF receptor family Seven transmembrane helix family The immunoglobulin superfamily is characterized by one or more Ig domains which are regions of 70 to 110 amino acid residues homologous to either Ig V or C domains. Examples include receptors for IL-1 and M-CSF. |
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[Home] [Cytokines] [Description] [Features & Philosophy] [Comparison] |
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[Class I] [Class II] [What is a Chemokine] [Chemokine Receptor Family] |
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Pathology Course Menu | Pathology | NJMed P.C. | NJMS | Search | UMDNJ |
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Please direct questions and coments to Alexander G. Izaguirre izaguial@umdnj.edu |
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