The Freundlich group is a chemical biology lab that utilizes a multi-disciplinary approach to study infectious diseases, with a specific focus on tuberculosis. Within the Department of Pharmacology & Physiology and the Department of Medicine (Division of Infectious Diseases, Center for Emerging & Re-emerging Pathogens), we focus on 1) the development and application of novel computational methods to discover and optimize chemical probes with which to study the pathogenesis of disease and 2) the utilization of biological techniques to elucidate how each probe affects disease pathogenesis, often through the complex modulation of more than one biological target. We assert that this approach has significant potential to seed the discovery of novel biological targets and small molecule drug discovery hits/leads.
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