Our Mission and What Motivates Us
The Freundlich group is a chemical biology lab that utilizes a multi-disciplinary approach to study infectious diseases, with a specific focus on tuberculosis. Within the Department of Pharmacology & Physiology and the Department of Medicine (Division of Infectious Diseases, Center for Emerging & Re-emerging Pathogens), we focus on 1) the development and application of novel computational methods to discover and optimize chemical probes with which to study the pathogenesis of disease and 2) the utilization of biological techniques to elucidate how each probe affects disease pathogenesis, often through the complex modulation of more than one biological target. We assert that this approach has significant potential to seed the discovery of novel biological targets and small molecule drug discovery hits/leads.
10/23/2014 – Congratulations to Tom! Tom's biography was featured in Rutgers Today. Read it here to learn about his rock 'n roll career and to listen to some of the music that he helped create.
9/24/2014 – Congratulations to Alex on a group contribution to a large, multinational collaborative effort leading to an accepted paper in PLoS ONE entitled, "Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein!"
9/17/2014 – Congratulations to Alex for being selected to present his research in a talk at the Rutgers/Robert Wood Johnson Medical School's 6th Annual National Postdoc Appreciation Day Symposium, in Piscataway, NJ.
9/16/2014 – Congratulations to Joel and the group for earning a grant from the Charles and Johanna Busch Memorial Fund.
8/20/2014 – The website for our NIH-funded CETR is now live. Please visit http://njms.rutgers.edu/research/cetr/.
8/01/2014 – Congratulations to Tom Stratton for giving a great presentation at the successful completion of the Graduate School of Biomedical Sciences Undergraduate Summer Research Fellowship, which funded his research for the last few months.
8/01/2014 – Congratulations to Alex Perryman and Xin Wang on their paper with the Kozikowski, Jacobs, and Bishai groups on novel inhibitors of InhA, which was just accepted in ChemMedChem. Our contribution was performing molecular modeling, enzyme biochemistry and inhibition assays of the new small molecule inhibitors.
7/21/2014 – Congratulations to Tom Stratton, who was recently distinguished as an Anna and Bernard Senkowski Undergraduate Chemistry Scholar.