Cole LA, Natal B, Fox A, Cooper A, Kennedy CA, Connell ND, Sugalski G, Kulkarni M, Feravolo M, Lamba S. A Course in terror medicine: content and evaluations. Prehosp Disaster Med. 2016 Feb;31(1):98-101. doi: 10.1017/S1049023X15005579. Epub 2016 Jan 11. PubMed PMID: 26751384
Russo R, Chae R, Mukherjee S, Singleton EJ, Occi JL, Kadouri DE, Connell ND. 2015. Susceptibility of select agents to predation by predatory bacteria. Microorganisms Dec2; 3:903-912.
Forbes L, Ebsworth-Mojica K, DiDone L, Li SG, Freundlich JS, Connell N, Dunman PM, Krysan DJ. A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis. PLoS One. 2015 Jun 22;10(6):e0129234.
Clements JD, Connell ND, Dirks C, El-Faham M, Hay A, Heitman E, Stith JH, Bond EC, Colwell RR, Anestidou L, Husbands JL, Labov JB. 2014. Engaging actively with issues in the responsible conduct of science: lessons from international efforts are relevant for undergraduate education in the United States. CBE Life Sci Educ. 12(4): 596-603.
Diller DJ, Connell ND, Welsh WJ. (2015) Avalanche for shape and feature-based virtual screening with 3D alignment. J Comput Aided Mol Des. Oct 12.
Shatzkes K, Chae R, Tang C, Ramirez GC, Mukherjee S, Tsenova L, Connell ND, Kadouri DE. (2015) Examining the safety of respiratory and intravenous inoculation of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus in a mouse model. Scientific Reports 7;5:12899.
Budowle B, Connell ND, Bielecka-Oder A, Colwell RA, Corbett CR, Fletcher J, Forsman M, Kadavy DR, Markotic A, Morse SA, Murch RS, Sajantila A, Schmedes SE, Ternus KL, Turner SD and Minot S. (2014). Validation of High Throughput Sequencing and Microbial Forensics Applications. Investigative Genetics July 30:5-9.
Degen D, Feng Y, Zhang Y, Ebright KY, Ebright YW, Gigliotti M, Vahedian-Movahed H, Mandal S, Talaue M, Connell N, Arnold E, Fenical W, Ebright RH. (2014). Transcription inhibition by the depsipeptide antibiotic saliniamide A. Elife. 2014 Apr 30;3:e02451.
Ekins, S., Reynolds, R.C., Kim H., Koo, M.-S., Ekonomidids, M., Talaue, M., Paget, S.D., Woolhiser, L.K., Lenaerts, A.J., Bunin, B.A., Connell, N., Freundlich, J.S. (2013) Dual-event machine learning models to accelerate drug discovery. Chem Biol 20(3):370-378.
Srivastava A, Talaue M, Liu S, Degen D, Ebright RY, Sineva E, Chakraborty A, Druzhinin SY, Chatterjee S, Mukhopadhyay J, Ebright YW, Zozula A, Shen J, Sengupta S, Niedfeldt RR, Xin C, Kaneko T, Irschik H, Jansen R, Donadio S, Connell ND and Ebright RH. (2011) New target for inhibition of bacterial RNA polymerase:‘switch region’. Curr Opin Microbiol. 14(5):532-43.
Jacobus Pharmaceutical, Inc Connell (PI) 1/01/16-12/31/16
Studies in Mycobacteria Drug Discovery and Screening Contract
The goal of this contract is to screen chemicals for antimycobacterial efficacy in in vitro and ex vivo. There is no overlap between this work and the proposed experiments.
DARPA-14-51-PathPred-FP-002 Kadouri (PI) 2/01/15 – 1/31/20
Predatory bacteria, from basic research to application.
This project explores the possibility of harnessing the antibacterial activity of predatory bacteria like Bdellovibrio and Micavibrio ssp for development as an alternative therapeutic.
U19-AI109713 Perlin (PI) 04/25/14-03/31/19
Center to Develop Therapeutic Countermeasures to High-Threat Bacterial Agents
The major goal of this project is establishment of a Center of Excellence for Translational Research focused on development of compounds effective against drug-resistant bacterial pathogens.
R01 AI103507 Dunman (PI) 10/01/13 09/31/16
Development of AK-Based Assays for Antimicrobial Screening
The major goal of this project is to assess the use of the release of adenylate kinase as a reporter of bacterial cell lysis. The project will assess three adenylate-kinase-based antimicrobial screening in Mycobacteria, in bacterial biofilms, and in bacterial small-colony-variant strains.
R01-AI104660 (Ebright, PI) 01/15/13-01/14/18
Therapeutics for Drug-Resistant Bacteria: Pseudouridimycins
The major goal of this project is structure-based design, synthesis, and efficacy testing of novel pseudouridimycin analogs effective against drug resistant bacterial pathogens.
1R01AI098713 (Alland) 05/01/12-4/30/17
On Demand Blood Tests for Select Agent Diagnosis
The major goal of this project is to adapt GeneXpert technology (Cepheid) to the detection of Select Agents.