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Department of Microbiology, Biochemistry and Molecular Genetics

Deborah A. Lazzarino, M.A., Ph.D.

Assistant Dean, Research Administration At UMDNJ-NJMS

Assistant Professor
Administrative Director, Research Core Facilities
Affiliate, Graduate School of Biomedical Sciences

Department of Microbiology, Biochemistry and Molecular Genetics
lazzarda@njms.rutgers.edu
 
Research Office

Medical Science Building (MSB)
185 South Orange Avenue Room C-690
Newark, NJ 07101
Email: Assistant Giovanna Comer
Hours: 8:30-5:00 pm
Phone: (973) 972-1591
Fax: (973) 972-3585

Biography

Education

M.A., 1983, Columbia University
B.A., 1982, New York University
Ph.D., 1990, Columbia University

 

 

Publications

Relevant Publications:

Rota, L.M., Lazzarino, D.A., Ziegler A.N., Leroith, D., Wood, T.L. “Determining Mammosphere-Forming Potential: Application of the Limiting Dilution Analysis” [J Mammary Gland Biol Neoplasia, Jun;17 (2):119-23, Epub 2012 Jun 8 (PMID: 22678420)
Cannata, D., Lann, D., Wu, Y., Elis, S., Sun, H., Yakar, S., Lazzarino, D.A., Wood, T., and LeRoith, D. “Elevated Circulating IGF-1 Promotes Mammary Gland Development and Proliferation.” Endocrinology. 2010 Dec; 151(12): 5751-61. Epub 2010 Oct 6. (PMID: 20926579)
Novosyadlyy, R., Lann, D.E. Vijayakumar, A., Rowzee, A., Lazzarino, D.A., Fierz, Carboni, J.M., Gottardis, M. M., Pennisi, P.A., Molinolo, A.A., Kurshan, N., Mejia, W., Santopietro, S., Yakar, S., Wood, T.L., Derek LeRoith, D. “Insulin- mediated acceleration of breast cancer development and progression in a non-obese model of type 2 diabetes.” Cancer Research 2010 Jan 15; 70 (2): 741-51. Epub 2010 Jan 1 (PMID: 20068149)
Alagappan, A., Lazzarino, D.A., Felling, R.J., Balan, M., Sergei, V., Kotenko, S.V., and Levison, S.W. “Brain injury expands the numbers of neural stem cells and progenitors in the SVZ by enhancing their responsiveness to EGF.” ASN Neuro Journal, 2009 May 20; 1 (2). pii: e00009. doi: 10.1042/AN20090002. (PMID: 19570028)
Rowzee, A.M., Lazzarino, D.A., Rota, L., Sun, Z. and Wood, T.L. “IGF ligand and receptor regulation of mammary development.” Journal of Mammary Gland Biology and Neoplasia, 2008 Dec; 13 (4): 361-70. Epub 2008 Nov 20. (PMID: 19020961)
Romanelli, R., LeBeau, A.P., Fulmer, C.G., Lazzarino, D.A., Hochberg, A., and Wood, T L. “IGF type-I receptor internalization and recycling mediate the sustained phosphorylation of AKT.” Journal of Biological Chemistry 2007 Aug 3; 282 (31): 22513-24. Epub 2007 Jun 1. (PMID: 17545147)
Ishikawa, T., Hwang, K., Lazzarino, D., and Morris, P.L. “Sertoli cell expression of steroidogenic acute regulatory protein-related lipid transfer 1 and 5 domain-containing proteins and sterol regulatory element binding protein-1 are interleukin-1beta regulated by activation of c-Jun N-terminal kinase and cyclooxygenase-2 and cytokine induction.” Endocrinology 2005 Dec; 146 (12): 5100-11. Epub 2005 Aug 25 (PMID: 16123165)
Lazzarino, D.A., de Diego, M., Hirschman, S. Z., Zhang, K. Y., Shaikh, S., Musi, E., Liaw, L., and Alexander, R. J. “IL-8 and MCP-1 secretion is enhanced by the peptide-nucleic acid immunomodulator, Product R, in U937 cells and primary human monocytes.” Cytokine 2001 May 21; 14 (4): 234-9. (PMID: 11448124)
Lazzarino, D.A., Blier, P., and Mellman, I. "The monomeric GTPase rab4 controls an essential step on the pathway of receptor-mediated antigen processing in B cells." Journal of Experimental Medicine J Exp Med. 1998 Nov 16; 188 (10): 1769-74. (PMID: 9815254)
Lazzarino, D.A. and Gabel, C.A. "Biosynthesis of the mannose 6-phosphate recognition marker in transport-impaired mouse lymphoma cells: Demonstration of a two-step phosphorylation." Journal of Biological Chemistry 1988 Jul 25; 263 (21): 10118-26. (PMID: 2968980)

 

Current Research

Assistant Professor, Department of Microbiology and Molecular Genetics

We are interested in the cellular and molecular events that regulate the growth and differentiation of mammary
epithelial cells. In particular, we work to identify, isolate and characterize mammary stem and progenitor cells in hopes
of understanding the role they play in normal and disease states of the breast. Our research utilizes both in vivo animal
model systems and in vitro primary cell culture systems to identify and study stem and progenitor cells of the
mammary epithelium, using known and novel markers. The cell signaling pathways that regulate stem cell maintenance
and renewal are studied using various cellular and molecular biology tools in hopes of understanding the regulation of
stem and progenitor cells in normal and cancerous states. In particular, the hormonal and insulin-like growth factor
responses of mammary stem and progenitor cells are monitored relative to well know stem cell renewal pathways to
better understand the normal and oncogenic potential of these signaling molecules.



 

 

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