Sean Ekins


Identifying new therapeutics for pathogens can leverage technologies that have been applied widely in other areas of drug discovery, such as cheminformatics. Previously generated whole cell or target-based screening data can be used to generate machine learning models which can in turn be used to select compounds from commercially available drug-like molecules. Such computational models can also be used to optimize the bioactivity as well as drug-like properties of lead compounds in parallel. This may enable more efficient drug discovery by testing compounds with a high probability of success.


Sean divides his time between clients at Collaborations In Chemistry which currently includes: Collaborative Drug Discovery, the Hereditary Neuropathy Foundation as well as biotechs and other companies. In addition he is CSO and President at Phoenix Nest focused on rare disease drug discovery. He graduated from the University of Aberdeen; receiving his M.Sc., Ph.D. and D.Sc. in Clinical Pharmacology. He was a postdoctoral fellow at Lilly Research Laboratories. He has worked as a senior scientist at Pfizer, Lilly, Associate Director of Computational Drug Discovery at Concurrent Pharmaceuticals Inc. (now Vitae Pharmaceuticals Inc), and Vice President of Computational Biology at GeneGo (now Thomson Reuters). Sean is Adjunct Professor, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill; Adjunct Associate Professor, School of Pharmacy Department of Pharmaceutical Sciences, University of Maryland and Adjunct Professor in the Department of Pharmacology at Rutgers University– Robert Wood Johnson Medical School, Piscataway, NJ. Sean is on the scientific advisory board for several companies and editorial boards of the Journal of Pharmacological and Toxicological Methods, Drug Discovery Today, Mutation Research Reviews, and Pharmaceutical Research. He has authored or co-authored >220 peer reviewed papers and book chapters as well as edited four books for Wiley. Sean co-developed the mobile apps ODDT (Open Drug Discovery Teams) and TB Mobile and has been awarded multiple NIH grants.

Sean Ekins PhD, DSc

Phone 215-687-1320

Collaborations In Chemistry
5616 Hilltop Needmore Road,
Fuquay-Varina, NC 27526
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