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General Information

Rationale:
The purpose of this course is to provide students with an understanding of how dysfunctions in the hematopoietic stem cells lead to clinical abnormalities (diseases). In addition, students will learn how attempts are being made to solve the clinical problems and how these solutions were derived from an understanding of basic biology: biochemistry, cellular and molecular biology.

Hematology has been at the forefront of advances in non-bone marrow stem cells. The subject of hematology involves studies of bone marrow-resident stem cells and the influences of the microenvironment and the immune system on homeostasis of the bone marrow. An understanding of the aberrant stem cell mechanisms, which underlie hematological diseases will provide paradigms for further study of other stem cells and their application in clinical medicine.  This course will illustrate how our increasing knowledge of the biology of hematopoietic and, other bone marrow-derived stem cells can provide new insights into the clinical features of hematologic disease.

The following is an example of the stepwise method intended to discuss the pathophysiology of a hematological disorder:

1. Lectures describing the basic science of the disease and the evolution of new drug targets.
2. The outcome of clinical trials with the advent of drug resistance.
3. Lectures on how the bedside outcome leads back to the bench.  

The course will be mostly didactic lectures with discussions related to the lecture material. There will be three exams.

Required Text:
Clinical Hematology, Edited by Neal S. Young, Stanton L. Gerson and Katherine A. High. Mosby Elsvier, ISBN 0-323-01908-0

Printing Instructions:
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