Jiang-Hong Ye, MD, MSc
Professor of Anesthesiology,
Pharmacology & Physiology
Rutgers -RHBS New Jersey Medical School
Medical Sciences Building, E586
185 S. Orange Avenue
Newark, NJ 07103
Office Phone: (973) 972-1866
Lab Phone: (973) 972-4399
Fax: (973) 972-4172
Email: ye. jianghong@rutgers.edu

 BIOGRAPHICAL SKETCH

Education/Training
Sun Yat-sen University of Medical Sciences, China, MD, 1969
Sun Yat-sen University of Medical Sciences, China, MSc, Neuroscience

A. Positions and Honors
Positions and Employment
1983-1993 Assistant-Associate Professor, Department of Physiology, Sun Yat-Sen Univ. Med Sci
1994-1998 Assistant Professor, Anesthesiology, New Jersey Medical School
1999-2007 Associate Professor, Anesthesiology, New Jersey Medical School
2008-present Professor, Anesthesiology, New Jersey Med School

Other Experience and Professional Memberships
Current Editorial Boards –
1) Int J Physiol Pathophysiol Pharmacol (IJPPP)
2) The Open Journal of Neuroscience
Ad hoc reviewer for 46 American and international journals

2011-2015, Member, NIH, the Neurotoxicology and Alcohol Study Section
1998- 2010, Ad hoc member, NIH, NCCAM Special Emphasis Panels
2009-2010, Ad hoc member, NIH Special Emphasize Panel/ Scientific Review Group ZRG1 1FCV-A (03)
NIH Special Emphasize Panel/ Scientific Review Group NAL, at hoc (2/2010)

B. Selected publications (selected from 95 publications).
Alcohol addiction and mesolimbic system:

Ye JH*, Wang F, Krnjevic K, Wang W, Xiong ZG, Zhang J.  Presynaptic glycine receptors on GABAergic terminals facilitate discharge of dopaminergic neurons in ventral tegmental area. J Neurosci. 24(41):8961-74, 2004.

Wang FS, Xiao C, Ye JH*. Taurine activates excitatory non-synaptic glycine receptors on dopaminergic neurons in ventral tegmental area of young rats. J. Physiology, 565:503-516, 2005
Ye JH*, Zhang J, Xiao C, Kong JQ. Patch clamp studies in the CNS illustrate a simple new method for obtaining viable neurons in rat brain slices: glycerol replacement of NaCl protects CNS neurons. J. Neurosci Methods, 158:251-259, 2006.

Ye JH*, Tao L, Ren J, Schaefer R, Krnjevic K, Liu PL, Schiller DA, McArdle JJ. Ethanol potentiation of glycine-induced responses in dissociated neurons of rat ventral tegmental area. J. Pharmacol. Exp. Ther. 296(1):77-83, 2001.

Xiao C, Zhang J, Krnjevic K, Ye JH*. Effects of ethanol on midbrain neurons: Role of opioid receptors. Alcoholism: Clin Exp Res. 31(7):1106-1113, 2007.

Xiao C, Ye JH*. Ethanol dually modulates GABAergic synaptic transmission onto dopaminergic neurons in ventral tegmental area: role of µ-opioid receptors. Neuroscience, 153(1):240-8, 2008.

Xiao C, Shao XM, Olive MF, Griffin WC, Li KY, Krnjevic K, Zhou C, Ye JH*.  Ethanol increases glutamate release to dopamine neurons in the ventral tegmental area in midbrain slices of rats. Neuropsychopharmacology, 34(2):307-18, 2009.  NIHMSID # 105593

Deng C, Zhou C, Li KY, Ye JH*. Ethanol Enhances Glutamate Transmission via Retrograde Dopamine Signaling in a Postsynaptic Neuron/Synaptic Bouton Preparation from the Ventral Tegmental Area. Neuropsychopharmacology, 34(5):1233-44, 2009. NIHMSID # 105605

Guan YZ, Ye JH*. Ethanol blocks long-term potentiation of GABAergic synapses in the ventral tegmental area involving µ-opioid receptors. Neuropsychopharmacology, 2010;35(9):1841-9. PMID: 20393452.

Li J, Cheng Y, Bian W, Liu X, Zhang C, Ye JH*. Region-specific induction of FosB/ΔFosB by voluntary alcohol intake: effects of naltrexone. Alcohol Clin Exp Res. 34(10):1742-50, 2010. PMID: 20626732

Li J, Bian W, Dave D, Ye JH*. Blockade of GABAA Receptors in the Paraventricular Nucleus of the Hypothalamus Attenuates Voluntary Ethanol Intake and Activates the Hypothalamic-Pituitary-Adrenocortical Axis. Addiction Biology, 2011;16(4):600-14. PMID: 21762292.

Li J, Nie H, Bian W, Dave V, Janak PH, Ye JH*. Microinjection of Glycine into the Ventral Tegmental Area Selectively Decreases Ethanol Consumption. J Pharmacol Exp Ther. 2012;341(1):196-204. PMID: 22238211.

Li JY, Li J, Liu X, Qin S, Guan Y, Liu Y, Cheng Y, Chen X, Li W, Wang S, Xiong M, Kuzhikandathil EV, Ye JH*, Zhang C*. MicroRNA Expression Profile and Functional Analysis Reveal that miR-382 is a Critical Novel Gene of Alcohol Addiction. EMBO Molecular Medicine, 2013, Jul 22. doi: 10.1002/emmm.201201900.

General anesthetics and related drugs:
Ye JH*, Mui WC, Ren J, Hunt TE, Wu WH, Zbuzek VK. Ondansetron exhibits the properties of a local anesthetic. Anesthesia and Analgesia. 85: 1116-1121, 1997.

Ye JH*, Ponnudurai R, Schaefer R S. Ondansetron, a CNS drug. CNS Drug Review. 7:199-213, 2001.

Feng X, Liu JJ, Zhou X, Song FH, Yang XY, Chen XS, Huang WQ, Zhou LH, Ye JH. Single sevoflurane exposure decreases neuronal nitric oxide synthase levels in the hippocampus of developing rats. Br J Anaesth. 2012. PMID: 22535834.

Liu YW, Zuo W, Ye JH*. Propofol Stimulates Noradrenalin-Inhibited Neurons in the Ventrolateral Preoptic Nucleus by Reducing GABAergic Inhibition. Anesth Analg. 2013. PubMed PMID: 23780420.

Nguyen HT, Li KY, da Graca RL, Delphin E,  Xiong M, Ye JH*. Behavior and Cellular Evidence for Propofol induced Sedation Involving Brain Glycine Receptors. Anesthesiology, 110:326-332, 2009.

Li KY, Guan YZ, Krnjević K, Ye JH*. Propofol facilitates glutamatergic transmission to neurons of the ventrolateral preoptic nucleus. Anesthesiology, 2009 111(6):1271-8. PMID: 19934872; PMCID: PMC2798160.

Liu YW, Li J, Ye JH*.HISTAMINE REGULATES ACTIVITIES OF NEURONS IN THE VENTROLATERAL PREOPTIC NUCLEUS. J. Physiology, 588(Pt 21):4103-16, 2010.

Stem cell research:
Cho KJ, Trzaska KA, Greco SJ, McArdle J, Wang FS, Ye JH, Rameshwar P*.  Neurons derived from human mesenchymal stem cells show synaptic transmission and can be induced to produce the neurotransmitter substance P by interleukin-1alpha.  Stem Cells. 23(3):383-391, 2005.

Greco SJ, Zhou C, Ye JH, Rameshwar* P. An interdisciplinary approach and characterization of neuronal cells transdifferentiated from human mesenchymal stem cells. Stem Cells and Dev 16:811-826, 2007.

Trzaska KA, Li KY, Kuzhikandathil EV, Nowycky MC, Ye JH, Rameshwar P*. Brain Derived Neurotrophic Factor (BDNF) Promotes Maturation of Human Mesenchymal Stem Cell-Derived Dopamine Progenitors. J Neurochemistry, 2009 110(3):1058-69.PMID: 19493166

Research Interests:
The laboratory is engaged in research in two areas: 1. Mechanisms of alcohol addiction. 2. Mechanisms of general anesthetics. In addition to the fact that alcohol is a general anesthetic, these two research areas are related in terms of many of the techniques used, which include: electrophysiological recordings in brain slices and isolated neurons, morphological immunocytochemistry and behavioral approaches.
Our work on alcohol addiction is directed towards understanding the mechanisms by which ethanol increase the excitability of dopaminergic neurons. The laboratory is particularly interested in the role of the GABAergic and glutamatergic inputs to the dopaminergic neurons of the ventral tegmental area; a brain region mediates the rewarding effects of abused drugs including alcohol. Additionally, we are interested in the mechanisms underlying the adaptation changes in the mesolimbic circuitries induced by chronic alcohol (drug) exposure.
Our work on general anesthetics is directed towards understanding the mechanisms by which anesthetics induce sedation. There is recent evidence that the sedative effects of general anesthetics are associated with the endogenous sleep pathways.  Our works focus on the ventral lateral preoptic area (VLPO). 

Current collaborators:

Kresimir Krnjevic is a Professor Emeritus in the Department of Physiology
McGill University. He is an expert in neurotransmitters, neurophysiology and synaptic plasticity.
We have been collaborated in numerous projects.
http://www.medicine.mcgill.ca/physio/staffpages/kkrnjevic.htm

ProfessorAllan Siegel is an Emeritus at the Department of Neuroscience, Rutgers, The State University of New Jersey.  He is an expert in behavior and neuroimmunology. 

We have collaborative projects on toxicity of general anesthetics.

http://njms.rutgers.edu/resource_locator/find_people/profile.cfm?mbmid=siegel#tab-bio

 Patricia Janak is a Professor of Neurology, UCSF, Howard J. Weinberger, MD, Endowed Chair in Addiction Research, UCSF. She is an expert in studying EtOH drinking behavior, among many others.
We have collaborative project on “Glycine regulates ethanol intake”

http://keck.ucsf.edu/neurograd/faculty/janak.html

M. Foster Olive is an associate professor at the Department of Psychology at Arizona State University. 
He is an expert in microdialysis and behavioral pharmacology.
We have collaborative projects on: 1) Alcohol and mesolimbic glutamatergic transmission, 2) Glycine regulation of ethanol intake, and 3) Mechanisms of regulation of ethanol intake by the lateral habenula. http://psychology.clas.asu.edu/faculty/m-foster-olive

Xuesi M Shao, MD., is an associate professor at the Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles. mshao@ucla.edu
He is an expert in delivery of nicotine or other drugs of abuse to rodents via lung alveolar region-targeted aerosol technology in vivo, measuring neurotransmitters in brain slices and nicotinic receptors in the respiratory center. We have collaborative project on Alcohol and mesolimbic glutamatergic transmissions.

Tibor Koós, Ph.D. is a Research Assistant professor in The Laboratory for Basal Ganglia Research, Center for Molecular and Behavioral Neuroscience, Aidekman Research, Rutgers, the State University of New Jersey.
He is an expert in both with in vitro and in vivo application of excitatory and inhibitory optogenetic tools and his lab is equipped with all necessary instrumentation for virus vector construction and production, stereotactic virus injection, construction and implantation of fiberoptic light guides and tetrode assemblies, and intracerebral multi-wavelength laser stimulation. We have collaborative projects on: 1) Mechanisms of regulation of ethanol intake by lateral habenula, and 2) Role of Rostromedial Tegmental Nucleus in alcohol addiction. http://www.ncas.rutgers.edu/tibor-koos