Our diverse and complex patient population has allowed us to perform important clinical research, both locally and as part of multi-center trials. We have participated in landmark trials such as the ALMS trial and Aurora trial and others in treatment of lupus nephritis, the Figaro and Fidelio trials in treatment of diabetic nephropathy, the FSGS-CT trial (of FSGS), as well as trials in hypertension, hyponatremia, and vaccination.
Current projects include ongoing trials in lupus nephritis and in non-diabetic proteinuric kidney disease, and pending projects include trials of treatment of acute kidney injury in cirrhosis.
In addition to these research activities, we participate in quality improvement projects in our institution, including a project to improve hypertension management in our primary medicine clinics.
Rothpletz-Puglia P, Brown TL, Peters E, Thomas-Hawkins C, Kaplan J, Myslinski MJ, Mysliwiec J, Parrott JS, Byham-Gray L. Functional Status and Engagement in Physical Activity Among Maintenance Dialysis Patients: A Mixed Methods Study. Kidney Med. 2022 Apr 25;4(6):100469. doi: 10.1016/j.xkme.2022.100469. PMID: 35620085; PMCID: PMC9127694.
Rovin BH, Teng YKO, Ginzler EM, Arriens C, Caster DJ, Romero-Diaz J, Gibson K, Kaplan J, Lisk L, Navarra S, Parikh SV, Randhawa S, Solomons N, Huizinga RB. Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 2021 May 29;397(10289):2070-2080. doi: 10.1016/S0140-6736(21)00578-X. Epub 2021 May 7. Erratum in: Lancet. 2021 May 29;397(10289):2048. PMID: 33971155.
Bageac, Devin, DeBevits, John, Munbodh, Reshma, Kaplan, Joshua, Wu, Rong, DiCamillo, Paul, Hu, Chaoran, Wang, Yanlin, Karimeddini, David, Naismith, Robert, Dhib-Jalbut, Suhayl, and Wolansky, Leo. (2020). MRI demonstration of gadolinium deposition in bone after monthly triple-dose gadopentetate dimeglumine and correlation with frequency of hypophosphatemia. Clinical Imaging. 70. 10.1016/j.clinimag.2020.07.022.
Kaplan JM, “Roxadustat and Anemia of Chronic Kidney Disease,” N Engl J Med 2019; 381:1070-1072; doi: 10.1056/NEJMe1908978.
