DENT 5310Q - Oral Immunology Spring 2024

COURSE DESCRIPTION:
This course is geared to provide students with understanding of basic concepts of immunology. The course content will include immunological processes within the periodontium; immunological processes within the crevicular fluid; immunological processes within the saliva; and immunological processes within the endodontium. The course will also cover neoplasia of the oral cavity, dental caries, periodontal disease, as well as immunological mediators of inflammation and pain.

COURSE OBJECTIVES:
At the completion of this course students will be able to:

• Define the anatomy and organization of the immune system.
• Describe the cells that comprise the immune system and their major functions.
• Distinguish between innate and adaptive immune responses, and how they intersect.
• Appreciate the strategies employed by the immune system in combating local and systemic host diseases.
• Distinguish between the four types of hypersensitivity reaction.
• Describe the basis of immunologic tolerance and development of autoimmune diseases.
• Describe and distinguish between transplant rejection and graft-versus host disease.
• Define how failure of immune surveillance leads or neoplasia, including oral neoplasia.
• Recognize and describe immunological bases of pathologic conditions in the oral cavity, and how they lead to systemic diseases.

 

COURSE FORMAT:
Lectures

FACULTY AND STAFF:

 

 

RECOMMENDED COURSE TEXTBOOKS:
Janeway's Immunobiology, 10th edition, 2023, Kenneth Murphy, Casey Weaver, ISBN: 978-0-393-68093-5. Rutgers - George F. Smith Library of the Health Sciences.
This is the main textbook for the course, but material will be taken from other sources, including the following:
•          Immunology: A Short Course, 7th edition, 2015. Richard Coico and Geoffrey Sunshine, Wiley-Blackwell, ISBN: 978-0-470-08158-7.
•          Cellular and Molecular Immunology, 9th edition, 2018, AK. Abbas, AHH. Lichtman, S Pillai: Elsevier Saunders ISBN 9780323222754.
•          Immunology, 8th edition, 2013, David Male, Jonathan Brostoff, David B. Roth, and Ivan Roitt, Elsevier. Print Book ISBN :9780323080583; Paperback ISBN: 9780323080583.

DENT 5310Q - Oral Immunology Course Schedule
Spring 2024

Week	Date	Day	Time	Lecture Session	Topic	Instructor	Notes
1	Mar 18	Mon	2-2:50p	1 (B963)	Basic Principles of Immunology-Introduction	Tsiagbe	Janeway 10th Ed, Chapter 1
	Mar 18	Mon	3-3:50p	2 (B963)	Origin and Cells of the immune System	Tsiagbe	Janeway Chapter 1
	Mar 19	Tue	11-11:50a	3 (B963)	Functional organization of the Immune System	Tsiagbe	Janeway Chapter 1
	Mar 19	Tue	12-12:50p	4 (B963)	Innate Immunity, Part I	Tsiagbe	Janeway Chapter 2, 6
	Mar 20	Wed	10-10:50a	5 (B963)	Innate Immunity, Part II	Tsiagbe	Janeway Chapter 2, 6
	Mar 20	Wed	11-11:50a	6 (B963)	Adaptive Immunity: Humoral Immune Response	Tsiagbe	Janeway Chapter 10-11

2	Mar 25	Mon	2-2:50p	7 (B963)	Complement Pathways	Rohowsky-Kochan	Janeway Pg. 49-74
	Mar 25	Mon	3-3:50p	8 (B963)	Adaptive Immunity: T cell-mediated Immunity - Implications in cancer	Tsiagbe	Janeway Chapter 8-9
	Mar 26	Tue	11-11:50a	9 (B963)	Mucosal Immunity & Oral Tolerance	Tsiagbe	Janeway Chapter 11-12
	Mar 26	Tue	12-12:50p	10 (B963)	Hypersensitivity Reactions - Part 1	Tsiagbe	Janeway Chapter 14
	Mar 27	Wed	8-8:50a	11 (B961?)	Hypersensitivity Reactions - Part 2	Tsiagbe	Janeway Chapter 14
	Mar 27	Wed	9-9:50a	12 (B961?)	Pre-exam1 Review (covers Lec 1-11)

 

3	Apr 2	Tue	8-9:50p	EXAM 1 (B965, & B963)	Covers Lectures 1-11	Tsiagbe	RM B963/B965
	Apr 2	Tue	11-11:50a	13 (B963)	MHC & Antigen Recognition	Tsiagbe	Janeway Chapter 3,4,5
	Apr 2	Tue	12-12:50p	14 (B963)	Tolerance & Autoimmunity	Tsiagbe	Janeway Chapter 15
	Apr 2	Tue	2-2:30	Secure Exam Review (B965)
	Apr 3	Wed	11-11:50a	15 (B963)	Transplantation	Tsiagbe	Janeway Chapter 13
	Apr 3	Wed	11-12:50	16 (B963)	Immune modulation & Vaccines	Tsiagbe	Janeway Chapter 15
4	Apr 8	Mon	2-2:50p	17 (B963)	Oral Neoplasia	Tsiagbe
	Apr 8	Mon	3-3:50p	18 (B963)	Oral Diseases and Host Response	Fine
	Apr 9	Tue	11-11:50a	19 (B963)	Dental Caries	Fine
	Apr 9	Tue	12-12:50p	20 (B963	Apical Immunology	Fine
	Apr 9	Tue	2-2:50p	21 (B963)	Periodontal Disease I	Fine
	Apr 9	Tue	3-3:50p	22 (B963)	Periodontal Disease II	Fine
	Apr 15	Mon	2-3:50p	23 (B963)	Pre-Exam 2 Review

5	April 17	Wed	8-9:50p	EXAM 2 (Cumulative): B961 & B721
6	April 22	Mon	4-4:30p	Secure Final Exam Review (B963)

NOTE:  All SGS students in SDM D1 courses will use SDM Enterprise version of Examplify (NOT SGS Legacy version of Examsoft).  Students must follow the guidelines provided by SDM to download the correct version of Exemplify. Students will also be required to take SDM practice Exam on SDM Enterprise Examplify, prior to exams.

EVALUATION METHODS & COURSE GRADING
Assessment/Evaluation:
Multiple choice mid-term and final exams, on ExamSoft.  Each exam will be for 110 minutes
Estimation of Weighted Course Average           

Course Grading:
Description                 Grade Points              Exam Scores
Letter Grade
A          Excellent                     4.00                             90-100
B+                                            3.50                             85-89
B          Average                       3.00                             80-84
C+                                            2.50                             75.79
C          Fair                              2.00                             70-74
F          Fail                              0.00                             Below 70
For calculation of final course grades, decimal values are rounded up to the next whole number. If .5 or above or rounded down to the whole number if below .5, e.g., 89.5 would be an "A" and 89.4 would be a "B+."

EDUCATION PORTAL AND CANVAS COURSE ACCESS:
The CANVAS course website is an essential part of the ­­­­­­­­­­­­­­­­­­Oral Immunology Course. CANVAS can be accessed using the Educational Portal website at https://ep.njms.rutgers.edu . The Education Portal provides single sign-on and “one stop shopping” site for various academic systems such as CANVAS, Education Management System, Digital Media Portal, Virtual Microscopy, SOCRATES, etc.
If the Education Portal is unavailable, direct links for CANVAS, NJMS Video, Virtual Microscopy etc., are provided below:
CANVAS: To access all course information log onto CANVAS at: https://canvas.rutgers.edu/
PODCAST ACCESS:

 

WIRELESS ACCESS FOR ELECTRONIC EXAMS (ON CAMPUS EXAMS)
RU Health Sciences is the primary wireless network for SGS however you can use either RU Health Sciences or RU Wireless Secure for electronic exams. Please make sure you can connect to both prior to an exam. See https://ruwireless.rutgers.edu/ruwireless-secure for more information. DO NOT USE RU Wireless.

 

EXAMSOFT SYSTEM REQUIREMENTS:
Note: These requirements will be updated by the SGS Office of Student Affairs and Admissions. The requirements below are from the 2019-2020 Academic year:
EXAMSOFT SYSTEM REQUIREMENTS:
     The following laptop requirements are necessary for the School of Graduate Studies

EXAMSOFT EXAMPLIFY LINKS:
Mac : https://examsoft.force.com/emcommunity/s/article/Examplify-Minimum-System-Requirements-for-Mac-OS-X
Windows: https://examsoft.force.com/emcommunity/s/article/Examplify-Minimum-System-Requirements-for-Windows
THE EXAMSOFT PLATFORM FOR DENTAL SCHOOL D1 COURSES IS THE “ENTERPRISE EAMPLIF”Y NOT LEGACY EXAMSOFT USED BY SGS.

 

ABSENCE FROM COURSE QUIZZES AND EXAMS:
SGS has issued a MISSED EXAM POLICY for students enrolled in their programs. Below are the valid excuses for missing a quiz or exam in this course (verbatim from the SGS Exam Policy):

• Significant illness, with official note by doctor, which must include a valid reason for missing the exam. The doctor’s note cannot result from a remote (online) diagnosis. NOTE: Illness prior to the exam ("didn’t have time to study") does not constitute a valid excuse, although exceptions can be given by the SGS Associate Dean of Student Affairs if the prior illness has been severe or lengthy.
• Death in the immediate family (parents, siblings, children, grandparents, aunts/uncles, niece or nephew, sister-in-law or brother-in-law, parents-in-law, first-cousins). Verification, with dates, is required, but this can be a newspaper announcement, event (e.g. wake) announcement, etc.
• Medical/dental school interview, in which the interview or unavoidable travel overlaps with the exam. Copy of the invitation letter.
• Presentation at a meeting. Proof of attendance required.
• More than two final exams on the same day. (NOTE: An exam should not be rescheduled for an individual with two exams on the same day). If a student has more than two exams on the same day, they will need to contact the SGS Associate Dean of Student Affairs, who will contact the course directors about allowing the student to take one of the exams on a different day. The vast majority of schools across the country, including Rutgers New Brunswick, allow up to two final exam in the same day.
• SGS students enrolled in Dental School courses which are cross listed with SGS courses, must abide by the following guidelines: Exam excuses must be obtained by filling “SGS STUDENT RSDM EXAM ABSENCE REQUEST FORM”.  This form must be completed and emailed to Dr. Markowitz (markowkj@sdm.rutgers.edu ) along with documentation substantiating the reason for absence for any RSDM exam absence request. This will be rare, but is meant to account for valid, but unforeseen circumstances. Each of these reasons will require some form of documentation to be submitted to verify the absence. For the full policy, please follow this link: http://njms.rutgers.edu/sgs/current_students/docs/new/ExamPolicy.pdf

CODE OF PROFESSIONAL CONDUCT (COURSE EXAMINATIONS):
All students have a fundamental responsibility for maintaining academic integrity and intellectual honesty in their academic and professional endeavors. They are expected to observe generally accepted principles of scholarly work, to submit their own rather than another's work, to refrain from falsifying data, to acknowledge the published work of others in an appropriate manner, and to refrain from receiving or giving aid during examinations or other work requiring independent effort. When submitting written material, students take full responsibility for the originality of all work not otherwise identified by appropriate acknowledgments and imply that both the ideas and words used are their own. All students are expected to respect the property of faculty and other students, and not use research equipment or laboratory supplies of others without permission.
Specific examples of appropriate behavior in examinations exams are given below:
Examinations: The purpose of an examination is to assess a student's knowledge of a topic defined within a course or courses. Unless given explicit written instructions to the contrary, a student must work without assistance on an examination.

• Classroom examination: Each student will provide answers to questions as directed. Unless otherwise stated, no material (books, calculators, computers, communication devices) of any kind can be used during an examination.
• Take-home examination: Each student will provide answers as directed. Unless otherwise stated, research and writing must be done individually without assistance or exchange of information with others. The ability to use source material in the research of answers will be defined for each examination. But, unless stated otherwise, all source material should be cited appropriately as outlined below.

NOTE: These policies also hold true for ALL exams administered remotely.
To view the full policy for the Code of Professional Conduct in the School of Graduate studies regarding examinations, research and oral presentations follow this link: http://njms.rutgers.edu/sgs/current_students/ac_integ.php
ACADEMIC WARNING POLICY:
http://njms.rutgers.edu/sgs/documents/policys/SGS_Academic_Warning_Policy.pdf
Each program shall clearly inform students of the criteria for satisfactory academic performance.  Academic standing will be reviewed each semester by the Program’s Academic Standing Committee. Students who receive less than an average grade of “B” in the designated Core course(s) or have a GPA less than 3.0 will receive an academic warning notice. Students performing below satisfactory levels of proficiency as outlined by the program may also receive a written warning notice. The written warning states the problem(s), outlines those measures needed for improvement and sets a deadline for compliance. Letters informing students of an academic warning will be sent within 30 calendar days of the end of the semester. A request will be made to students receiving academic warning letters to meet with the Program Director and/or the Academic Standing Committee.

COURSE ADD/DROP POLICY:
Policy for the Addition of a Course:
Students may add courses with the approval of the instructor (when required) and the program director. A student wishing to add a course after the general registration period has closed, must complete the “Add/Drop/Withdraw” form and have appropriate approval of the course instructor (when required) and program director prior to the start of the course. Registration will not be permitted beyond the first week of a course. Credit will not be given for courses in which the student was not registered.
Add Course Form Link: https://na2.docusign.net/Member/PowerFormSigning.aspx?PowerFormId=96fcae95-bc67-45fb-8da3-11300ded2e99
Policy for Dropping a Course:
Students may drop courses with approval of the instructor (when required) and the program director. Students submitting a completed “Add/Drop/withdraw” form to the SGS Registrar’s office within 10 academic days of the start of the course will receive a full tuition refund and the course will not appear on their official transcript. The drop period of 1-10 *academic days, is distinguishable from the withdrawal period in that the drop period is without penalty. A completed and approved Add/Drop/Withdraw” form(s) must be received by the Registrar’s office within the time periods set forth above in order for a course(s) to be “dropped”.
Drop Course Form Link: https://na2.docusign.net/Member/PowerFormSigning.aspx?PowerFormId=c45635ca-6a1e-4936-b436-337b211b8433
*An academic day is defined as a day that the SGS campus at which the student is enrolled is open for business.

REASONABLE ACCOMMODATIONS AT RUTGERS SCHOOL OF GRADUATE STUDIES:
Rutgers School of Graduate Studies is committed to providing equitable access to learning opportunities to students with documented disabilities (e.g. mental health, attentional, learning, chronic health, sensory, or physical). To ensure access to this please contact Student Affairs, to engage in a confidential conversation about the process for requesting reasonable accommodations in the classroom setting. Students are encouraged to register with the Office of Student Affairs as soon as they begin their program. Accommodations are not provided retroactively. Rutgers School of Graduate Studies encourages students to access all resources available through the School for consistent support and access to their program.
More information can be found online at
http://njms.rutgers.edu/education/student_affairs/student_support/disability_services.cfm .
Rutgers University welcomes students with disabilities into all of the University's educational programs. In order to receive consideration for reasonable accommodations, a student with a disability must complete the ODS registration form: https://webapps.rutgers.edu/student-ods/forms/registration and contact the RBHS Office of Disability Services at 973-972-5396 or cindy.poorepariseau@rutgers.edu to make an appointment for an intake interview.  You will also be asked to provide documentation of your disability:
https://ods.rutgers.edu/students/documentation-guidelines .
If the documentation supports your request for reasonable accommodations, the Office of Disability Services will provide you with a Letter of Accommodations. This Letter will be used to notify appropriate school personnel about the accommodations you are qualified to receive. To begin this process, please complete the Registration form on the ODS web site at: https://webapps.rutgers.edu/student-ods/forms/registration .

 

TEACHER-LEARNER POLICY RUTGERS SCHOOL OF GRADUATE STUDIES:
The Rutgers SGS Newark Health Science Campus strongly believes that teaching and learning should take place in a climate of mutual respect where students and faculty are equally responsible for maintaining a professional and collegial environment. An environment where students are evaluated based upon accomplishment, professionalism and academic performance. We are committed to maintaining a positive learning environment and the highest standards of behavior in the teacher-student relationship.
To view the full Teacher-Learner policy for the School of Graduate studies, please follow this link: https://njms.rutgers.edu/sgs/current_students/docs/Teacher%20Learner%20Policy.pdf