Molecular Mechanisms of Diseases – CBNP 5068Q
Objectives: A. Introduction to Model Organisms and Selected Disease Models B. Molecular Dissection of Cancer, Aging Associated and Non-Mendelian Diseases The course "Understanding the Molecular Mechanisms of Diseases" introduces the use of model systems such as baker's yeast, flies, and mice to understand how diseases develop at a molecular and cellular level. The course starts with an overview about the various model systems and is followed by several mechanistic topics including angiogenesis, autophagy, apoptosis, cellular calcium metabolism, chromatin modifications, and DNA-specific processes (chromosomal and mitochondrial DNA) in aging, cancer, cardiovascular and mitochondrial diseases. Prerequisites: Background in Cell and Molecular Biology Course content: Introduction into yeast as a model system, Fly genetics and screens, Transgenic mouse models and heart diseases, Stem cells, Autophagy and cancer: from yeast to humans, Angiogenesis and cancer, Mitochondrial DNA in aging and diseases, Studies of cancer, aging, and heart disease in fly, Calcium handling in the heart, Mechanisms of heart failure: involvement of apoptosis, Histones and histone deacetylases in the heart, Convergent and divergent mechanisms in aging and cancer, Vascular stiffness during aging Textbook: There is no required textbook. Slide (pdf file) will be provided a week ahead.
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