Proteomics and Bioinformatics Research

The Center for Advanced Proteomics Research (CAPR) is located at Rutgers Biomedical and Health Sciences-New Jersey Medical School in Newark, NJ. We are equipped with state-of-the-art proteomics instruments and bioinformatics systems, including a Thermo Scientific Orbitrap Fusion Lumos Tribrid mass spectrometer coupled with a Dionex UltiMate 3000 RSLCnano system. With this advanced instrument, our team of experienced and responsive scientists have contributed to the success of researchers at Rutgers, in the NY area and from the world. We welcome new customers, collaborators and joint grant applications.

We offer comprehensive services for protein analysis at both cell and tissue levels in the context of disease development and regulation, featuring the most advanced proteomics technologies currently available, including

1) Protein identification and characterization;

2) Identification of post-translational modifications (PTMs), e.g. phosphorylation, nitrosylation, acetylation, methylation and disulfide bonds, etc.;

3) Global quantitation of proteins, e.g. Protein-protein interaction using label free quantitation, Differential protein expression using iTRAQ or TMT labeling, Global PTM quantitation using SILAC, iodo-TMT.

We have continuously focused on developing novel proteomics methods to study redox-signaling modifications, including s-nitrosylation, s-sulfonation, and disulfides. In addition, we have developed and optimized state-of-the-art proteomics approaches for global protein expression, protein PTMs and protein-protein interaction studies. Many of these are collaborative studies enabled the discovery of novel mechanistic insights in models of human diseases.

Please contact Dr. Hong Li to discuss your potential proteomics projects.

Recent Publications


  • Xiaowen Wang, Jun Yang, Justin Wong, Jessie Yanxiang Guo, Holly Van Remmen, Hong Li, Eileen White, Chen Liu, Megerditch Kiledjian and X.F. Steven Zheng (2021), SOD1 Is Crucial for Growth and Ribosome Biogenesis in KRAS-p53 Driven Lung Tumors in Mice. Nature Communications. In Press.
  • Baljinnyam E., Venkatesh S., Tong M., Yan L., Liu T., Li H., Xie L.-H., Suzuki C., Fraidenraich D., and Sadoshima J. (2021). Proteomic analysis of mitochondrial biogenesis in cardiomyocytes differentiated from human induced pluripotent stem cells. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 320(4):R547-R562. doi: 10.1152/ajpregu.00207.2020. 
  • Yadaw, A., Siddiq, M., Tolentino, R., Rabinovic,h V., Jayaraman, G., Jain, M., Liu, T., Li, H., Goldfarb, J., Iyengar, R., Hansen, J.  (2021) Whole cell response to receptor stimulation involves many deep and distributed subcellular processes. Submitted.


  • Davra, V., Saleh, T., Geng, K., Kimani, S., Mehta, D., Kasikara, C., Smith, B., Colangelo, N., Ciccarelli, B., Li, H., Azzam, E., Kalodimos, C., Birge, RB., Kumar, A., (2020) Cyclophilin A inhibitor Debio-025 targets Crk, reduces metastasis, and induces tumor immunogenicity in breast cancer. Mol Cancer Res Apr 22. pii: molcanres.1144.2019. doi: 10.1158/1541-7786.MCR-19-1144.
  • Marc A. Egerman, Jenny S. Wong, Tian Runxia , Gohar Mosoyan , Kinsuk Chauhan , Joselyn Reyes-Bahamonde , Nanditha Anandakrishnan , Nicholas J. Wong , Emilia Bagiella , Fadi Salem , Kristin Meliambro , Hong Li , Evren U. Azeloglu , Steven G. Coca , Kirk N. Campbell and Leopoldo Raij. (2020). Plasminogenuria is associated with podocyte injury, edema and kidney dysfunction in incident glomerular disease. The FASEB Journal. In Press.
  • Himelman E, Lillo MA, Nouet J, Gonzalez JP, Zhao Q, Xie LH, Li H, Liu T, Wehrens XH, Lampe PD, Fishman GI, Shirokova N, Contreras JE, Fraidenraich D. (2020) Prevention of Connexin43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy. J Clin Invest 130(4):1713-1727.








  • Fang Zhong, Haibing Chen, Evren U. Azeloglu Chengguo Wei , Weijia Zhang , Zhengzhe Li , Peter Y. Chuang , Belinda Jim, Hong Li, Hongyu Chen, Yongjun Wang, Weiping Jia, Kyung Lee, and John Cijiang He.(2015) Protein S Protects Against Podocyte Injury in Diabetic Nephropathy, JCI. submitted


  • Grant, J. E., Li, H., (2014). Identifying citrullination sites by mass spectrometry. In Protein Deimination in Human Health and Disease, Vol XIII, Springer, New York, Nicholas, A., Bhattacharya, S. (Ed)






  • Oka, S.-I., Ago, T., Liu, T., Li, H., Kitazono, T., Sadoshima, J., (2010). Redox Regulation of Class II Histone Deacetylases. in Methods in Redox Signaling (chap. 26), Das, D. (Ed.), Mary Ann Liebert, Inc., New Rochelle. p. 201-206


  • Liu, T., Hu, J., Li, H., in: Ottens, A. K., Wang, K. K. W. (Eds.), iTRAQ-Based Shotgun Neuroproteomics, Neuro Proteomics, Methods in Molecular Biology , Humana Press, Totowa 2009, p. 322.