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DENT 5145Q Introduction to Structural Biology

Fall 2020: 08/26/2020 – 12/16/2020
Wednesdays, 10:00 AM – 11:00 AM

Course Description

The generation of genomic information has exploded in recent years. However, scientists are falling behind in determining the functional implications of such information. The challenge centers on the ability of structural biologists to lead in determining the structures of biomolecules and their complexes to keep pace with the genetic information. A thorough understanding of macromolecular structures is required for the development of structure/function relationships. 

This course will introduce students to structural biology and to obtain a basic understanding of macromolecular structure, function and chemistry of biological macromolecules including proteins, nucleic acids and carbohydrates. Topics in protein folding will also be discussed. Introduction to specific methods for structure elucidation will include X-ray crystallography, nuclear magnetic resonance, and mass spectrometry. Macromolecular structure/function relationships as they relate to disease processes and therapies will also be discussed.

Course Aims
After the completion of the course, students should be able to:
1. Gain a basic understanding of macromolecular structure and building blocks
2. Describe the basic structural features and principles for techniques to determine the three-dimensional structure
3. Gain an appreciation of how dentist-scientists have used these techniques to fathom the biological functions of salivary proteins and other bacterial proteins
4. Gain hands on experience to analyze the macromolecular structure with molecular graphics programs

Expectations

Class lectures will be uploaded as modules – reading these before class is recommended.
Parts of the lectures that are required which provide valuable information for assignments and exams will be discussed at length during the class; parts that increase basic understanding will also be provided.

There will be two online exams. Grades will be based on cumulative scores.
No makeup exams will be given. Grades will not be curved
Grades              85 and above                  A           
                            80-84                                               B+
                            75-79                                               B
                            70-74                                               C+
                            65-69                                               C
                            <64                                                 

Recommended text books

              None – class notes are more than sufficient

Contact Info

I have an open office policy but due to the pandemic, please call me before visiting me. However, students are welcome to contact me at any time via email. The lectures will be recorded and uploaded online.

Dr. N. Ramasubbu

D830, RSDM

973 972 0704

ramasun1@sdm.rutgers.edu