CURRENT CARDIOLOGY CLINICAL TRIALS

INDUSTRY SPONSORED STUDIES:

1. RT-01-HF-REF: A Randomized, Phase 3, Placebo-Controlled, Double-Blind, Multicenter Trial of a One-time Intracoronary Administration of Human Adenovirus 5 encoding Human Adenylyl Cyclase Type 6 (RT-100) Gene Transfer for Patients with Heart Failure with Reduced Left Ventricular Ejection Fraction

   Sponsor: Renova Therapeutics

   Principal Investigator: Marc Klapholz, MD

    

2. GRAHF-2: Genomic Analysis of Enhanced Response to Heart Failure Therapy in African Americans

   Sponsor: NHLBI- Uni of Pittsburgh

   Principal Investigator: Pallavi Solanki, MD

    

3. AC-055-403: REPAIR STUDY: A prospective, multicenter, single-arm, open-label, Phase 4 study to evaluate the effects of macitentan on Right vEntricular remodeling in Pulmonary ArterIal hypeRtension assessed by cardiac magnetic resonance imaging)

   Sponsor: Actelion

   Principal Investigator: Alfonso Waller, MD

    

4. ADMIRE-ICD: AdreView™ Myocardial Imaging for Risk Evaluation – A multicentre trial to guide ICD implantation in NYHA class II & III heart failure patients with 30%≤LVEF≤35%.

   Sponsor: GE Healthcare

   Principal Investigator: Alfonso Waller, MD

    

5. BEAT- LUNG PAH: A multicenter, double-blind, randomized, placebo-controlled, Phase 3 study to assess the efficacy and safety of oral BPS-314d-MR added-on to treprostinil, inhaled (Tyvaso®) in subjects with pulmonary arterial hypertension

   Sponsor: Lung LLC

   Principal Investigator: Marc Klapholz, MD

    

6. RESPOND CRT: To assess the safety and effectiveness of the automatic atrioventricular (AV) delay and interventricular (VV) delay optimization algorithm used in the PARADYM RF SONR Cardiac Resynchronization Therapy with Defibrillation (CRT-D) device (Model 9770) in combination with the SonRtip Lead, which includes a SonR sensor in the tip of the atrial pacing lead, and compatible programming software.

   Sponsor: Sorin Group

   Principal Investigator: Victor Mazza, MD

    

    

INVESTIGATOR INITIATED CLINICAL TRIALS:

1. ST-Elevation Analysis Using Wireless Technology: Achieving the Golden Hour in Acute Myocardial Infarction- evaluating the efficacy of field based wireless ECG transmission in the treatment of STEMI. And their impact across gender and racial differences

   Principal Investigator: Marc Klapholz, MD

    

2. Retrospective evaluation of cardiovascular disease in patients with HIV infection at NJMS University Hospital

   Principal Investigator: Marc Klapholz, MD

    

3. Defining The Cardiovascular Sequelae In The Pre & Post Liver Transplant Patients

   Principal Investigator: Marc Klapholz, MD

    

4. GraftMaster® RX Coronary Stent Graft System

   Sponsor: Dept Funded

   Principal Investigator: Marc Klapholz, MD

    

5. Association Of Specific Protein Markers And Dilated Cardiomyopathy In African Americans

   Principal Investigator: Marc Klapholz, MD

    

6. Comparison of Left Ventricular Mass in Normal and Low Ejection Fraction Heart Failure

   Principal Investigator: Marc Klapholz, MD

    

7. Association of Early Repolarization with Cardiac Arrest following Acute Pulmonary Embolism

   Principal Investigator: Marc Klapholz, MD

    

8. Stress-induced cardiomyopathy

   Principal Investigator: Pallavi Solanki, MD

    

9. The Effects of High Power Potassium-Titanyl-Phosphate Laser Photoselective Vaporization Prostatectomy on Pacemakers and Implantable Cardioverter Defibrillators

   Principal Investigator: Victor Mazza, MD

    

10. The Effects of Extracorporeal Shockwave Lithotripsy on Pacemakers and Implantable Cardioverter Defibrillators

    Principal Investigator: Victor Mazza, MD

     

11. Evaluation of the of the association between Gender and Interventricular Mechanical Delay in a cohort of patients that are candidates for CRT Implantation

    Sponsor: Dept Funded

    Principal Investigator: Victor Mazza, MD

     

12. Defining the cardiovascular sequelae in patients with sarcoidosis

    Principal Investigator: Alfonso Waller, MD

     

13. The diagnostic accuracy of M-Mode in differentiating intra-cardiac from extra-cardiac shunting during agitated saline bubble-enhanced echocardiography.

    Principal Investigator: Alfonso Waller, MD

     

14. Safety of Transesophageal Echocardiogram with patients with esophageal and gastric varices.

    Principal Investigator: Alfonso Waller, MD