Recent Publications

Dr. Gunal:
1. Harony-Nicolas H, Kay M, Hoffmann JD, Klein ME, Bozdagi-Gunal O, Riad M, Daskalakis NP, Sonar S, Castillo PE, Hof PR, Shapiro ML, Baxter MG, Wagner S, Buxbaum JD.  Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat. Elife. 2017 Jan 31;6. PMID: 28139198

2. Kajiwara Y., McKenzie A., Dorr N., Gama Sosa M.A., Elder G., Schmeidler J., Dickstein D.L., Bozdagi O., Zhang B., Buxbaum J.D. The human-specific CASP4 gene product contributes to Alzheimer-related synaptic and behavioural deficits. Hum Mol Genet. 2016 Aug 11. pii: ddw265. PMID: 27516385

3. Hsiao K., Nicolas-Harony H., Buxbaum J.D., Bozdagi-Gunal O.*, Benson D.*; Cyfip1 regulates presynaptic function during development via WAVE1. Journal of Neuroscience February 3; 36(5):1564 –1576 (2016).

4. Uppal, N., Puri, R., Yuk, F., Janssen, W., Bozdagi-Gunal, O., Nicolas-Harony, H., Dickstein, D.L., Buxbaum, J.D. and Hof, P.R. Ultrastructural analyses in the hippocampus CA1 field in Shank3 deficient mice. Molecular Autism Jun 30;6:41 (2015).

5. Lin V., Jiang C., Sadahiro M., Bozdagi O., Vulchanova L., Alberini C., Salton S. VGF and its C-terminal peptide TLQP-62 regulate hippocampal dependent memory via a BDNF/TrkB-dependent mechanism. Journal of Neuroscience, Jul 15; 35(28):10343-56 (2015).

6. Kajiwara, Y., Schiff, T., Voloudakis, G., Gama-Sosa, M., Elder, G., Bozdagi, O., Buxbaum, J.D. (2014) A critical role for human caspase-4 in endotoxin sensitivity. Journal of Immunology. May 30. PMID: 24879791

7. Hsiao, K., Bozdagi, O. and Benson, D. Cap-dependent translation regulates presynaptic P35. Developmental Neurobiology. Nov 19 (2014) PMID: 24254883

8. Bozdagi, O., Tavassoli, T., Buxbaum, J.D. Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay. Molecular Autism. Apr 27;4(1):9 (2013) PMID: 23621888

10 . Bozdagi, O., Sakurai, T., Dorr, N., Pilorge, M., Takahashi, N., Buxbaum, J.D. Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice. PLoS One; 7(8): e42422 (2012)

11. Yang, M., Bozdagi, O., Scattoni ML, Wöhr M, Roullet FI, Katz AM, Abrams DN, Kalikhman D, Simon H, Woldeyohannes L, Zhang JY, Harris MJ, Saxena R, Silverman JL, Buxbaum JD, Crawley JN. Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice. Journal of Neuroscience, 2012 May 9;32(19):6525-41 (2012) PMID: 22573675

13. Takahashi, N., Sakurai, T., Bozdagi-Gunal, O., Dorr, N. P., Moy, J., Krug, L., Gama-Sosa, M., Elder, G. A., Koch, R. J., Walker, R. H., Hof, P. R., Davis, K. L. and Buxbaum, J. Increased expression of receptor phosphotyrosine phosphatase-β/ζ is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes. Translational Psychiatry 1, e8; doi:10.1038/ tp.2011. 8 Published online 10 May 2011.

14. Suzuki, A., Stern, S.*, Bozdagi, O.*, Huntley, G. W., Magistretti, P. and Alberini, C. M. The astrocyte-neuronal lactate-shuttle is required for long-term memory formation. Cell. Mar 4;144(5):810-23 (2011) PMID: 21376239

15. Bozdagi, O., Wang, X., Martinelli, G.P., Prell, G.D., Friedrich, V.L. Jr, Huntley, G.W., Holstein, G.R. Imidazoleacetic acid-Ribotide Induces Depression of Synaptic Responses in Hippocampus Through Activation of Imidazoline Receptors. Journal of Neurophysiology, Jan 12 (2011) PMID: 21228308 NIHMSID 270360

16. Bozdagi, O., Sakurai, T., Papapetrou, D., Wang, X., Dickstein, D.L., Takahashi, N., Kajiwara, Y., Yang, M., Katz, A.M., Scattoni, M.L., Harris, M.J., Saxena, R., Silverman, J.L., Crawley, J.N., Zhou, Q., Hof, P.R., Buxbaum, J.D. Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Molecular Autism. Dec 17;1(1):15 (2010) PMID: 21167025 PMC3019144

17. Bozdagi, O., Wang, X.B., Nikitczuk, J.S., Anderson, T.R., Bloss, E.B., Radice, G.L., Zhou, Q., Benson, D.L., Huntley, G.W. Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin. Journal of Neuroscience, Jul 28;30 (30):9984-9 (2010) PMID: 20668183 PMC2921177

18. Wang, X.B., Bozdagi, O., Nikitczuk, J.S., Zhai, Z.W., Zhou, Q., Huntley, G.W. Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately. Proceedings of National Academy of Sciences U S A. Dec 9;105 (49):19520-5 (2008) PMID: 19047646PMC2614793

19. Bozdagi, O., Rich, E., Tronel, S., Sadahiro, M., Patterson, K., Shapiro, M.L., Alberini, C.M., Huntley, G.W., Salton, S.R. The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism. Journal of Neuroscience, Sep 24;28 (39):9857-69 (2008) PMID: 18815270 PMC2820295

20. Nagy, V., Bozdagi, O. and Huntley, G. W. The extracellular protease matrix metalloproteinase-9 is activated by inhibitory avoidance learning and required for long-term memory. Learning and Memory 14: 655-664 (2007) PMID: 17909100 PMC 2044557

21. Bozdagi, O., Nagy, V., Kimberly, K. and Huntley, G. W. In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity. Journal of Neurophysiology, Jul;98 (1):334-44 (2007) PMID: 17493927 NIHMSID 270369

22. Nagy, V.*, Bozdagi, O.*, Matynia, A., Balcerzyk, M., Okulski, P., Dzwonek, J., Costa, R. M., Silva, A. J., Kaczmarek, L., and Huntley, G. W. Matrix Metalloproteinase-9 Is Required for Hippocampal Late-Phase Long-Term Potentiation and Memory. Journal of Neuroscience, 26(7):1923–1934 (2006) PMID: 16481424 NIHMSID 270379

23. Bozdagi, O., Valcin, M., Poskanzer, K., Tanaka, H. and Benson, D. L. Temporally Distinct demands for classic cadherins in synapse formation and maturation. Molecular and Cellular Neuroscience, 27(4): 509-521 (2004) PMID: 15555928 PMC2910522

24. Huntley, G.W., Gil, O. and Bozdagi, O.; The cadherin family of cell adhesion molecules: multiple roles in synaptic plasticity. The Neuroscientist 8:221-233, (2002)

27. Bozdagi, O., Shan,W. S., Tanaka, H., Benson, D.L. and Huntley, G.W. Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites and required for potentiation. Neuron, 28: 245–259 (2000) PMID: 11086998